The invention provides kidney-invigorating and yang-strengthening silkworm chrysalis health-care medicinal liquor and a preparation method thereof. The liquor comprises three groups of raw material medicines and white spirit: group A: 3-12 parts of silkworm chrysalis, 3-12 parts of silkworm moth, 1-15 parts of fresh cartialgenous, 10-15 parts of fresh fruit of Chinese wolfberry, 2-6 parts of stigma croci and 1.5-3 parts of prepared actinolite; group B: 3-9 parts of ginseng, 10-15 parts of prepared Polygonum multiflorum, 10-30 parts of radix rehmanniae preparata, 3-12 parts of Rhizoma Atractylodis Macrocephalae, 10-15 parts of Eucommia ulmoides, 10-15 parts of Astragalus membranaceus, 3-12 parts of prepared radix aconiti carmichaeli, 6-12 parts of pulp of dogwood fruit, 6-12 parts of herba epimedii, 9-12 parts of teasel root and 3-6 parts of polygala tenuifolia; and group C: 3-9 parts of rhizoma curculiginis, 6-12 parts of Lonicera japonica Thunb, 10-18 parts of cistanche, 6-10 parts of semen allii tuberose, 3-9 parts of fructus cnidii, 2-5 parts of shaved cinnamon bark, 6-12 parts of raspberry, 3-9 parts of Mulberry locust and 6-9 parts of prepared hedgehog hide. The liquor provided by the invention not only solves the problem of tonifying and nourishing kidney, but also solves the problem of necrospermia, asthenospermia and non semen liquefaction within a shorter time.