Rubber stopper material for cephalosporin drug and preparation method thereof

A technology for cephalosporins and rubber stoppers, applied in the field of chemical materials, can solve the problems of difficult processing, influence, poor rubber stopper performance, etc.

Inactive Publication Date: 2014-03-19
应城市恒天药业包装有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the poor material performance of the rubber plug, one or some substances in the interior have the defects of difficult processing and poor sealing performance, and some also release some odor, which will have a certain impact on the user.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0011] The invention is prepared by mixing the following raw materials according to weight percentage: 40% of butyl rubber, 20% of ethylene-propylene copolymer, 35% of filler, 3.5% of phenolic resin and 1.5% of coloring agent. The viscosity-average molecular weight of butyl rubber is 80,000, the Mooney viscosity ML1+8 (100°C) is 40 to 70, and the degree of unsaturation is 0.7 to 1.5 mol%. The melting point of ethylene-propylene copolymer is ≤120°C, the Mooney viscosity ML1+4 (100°C) is 40 to 80, partially cross-linked ethylene-propylene elastomer, and propylene grafted ethylene-propylene elastomer. The filler is mixed with clay, talcum powder and white carbon black in a weight ratio of 2:1:1. The preparation method is to knead the above-mentioned materials in a mixer, mix them under the condition of 130°C to 190°C, preferably 140°C to 160°C, and form them by compression molding or injection molding.

Embodiment 2

[0013] The invention is prepared by mixing the following raw materials according to weight percentage: 30% of butyl rubber, 15% of ethylene-propylene copolymer, 50% of filler, 4% of phenolic resin and 1% of coloring agent. The viscosity-average molecular weight of butyl rubber is 80,000, the Mooney viscosity ML1+8 (100°C) is 40 to 70, and the degree of unsaturation is 0.7 to 1.5 mol%. The melting point of ethylene-propylene copolymer is ≤120°C, the Mooney viscosity ML1+4 (100°C) is 40 to 80, partially cross-linked ethylene-propylene elastomer, and propylene grafted ethylene-propylene elastomer. The filler is mixed with clay, talcum powder and white carbon black in a weight ratio of 2:1:1. The preparation method is to knead the above-mentioned materials in a mixer, mix them under the condition of 130°C to 190°C, preferably 140°C to 160°C, and form them by compression molding or injection molding.

Embodiment 3

[0015] The invention is prepared by mixing the following raw materials according to weight percentage: 30% of halogenated butyl rubber, 20% of ethylene-propylene copolymer, 45% of filler, 4.5% of phenolic resin and 0.5% of coloring agent. The Mooney viscosity ML1+8 (100°C) of the halogenated butyl rubber is 40 to 70, the degree of unsaturation is 0.7 to 1.5 mol%, and the weight ratio of the halogen content is 0.5 to 3.0%. The melting point of ethylene-propylene copolymer is ≤120°C, and the Mooney viscosity ML1+4 (100°C) is 40 to 80. The filler is mixed with clay, talcum powder and white carbon black in a weight ratio of 2:1:1. The preparation method is to knead the above-mentioned materials in a mixer, mix them under the condition of 130°C to 190°C, preferably 140°C to 160°C, and form them by compression molding or injection molding.

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Abstract

The invention relates to a chemical material, and particularly relates to a rubber stopper material for a cephalosporin drug and a preparation method thereof. The rubber stopper material is prepared by mixing the following raw materials by weight percent: 20-40% of synthetic rubber, 10-20% of thermoplastic elastomer, 30-50% of filler, 3-8.5% of crosslinking agent and 0.5-1.5% of coloring agent, wherein the synthetic rubber is butyl rubber, polyisobutene or halogenated butyl rubber; the thermoplastic elastomer is a styrene elastomer or a polyolefin thermoplastic elastomer; the filler is one or more of kaoline, talcum powder and white carbon black; the crosslinking agent is metal oxide or phenolic resin; the coloring agent is titanium dioxide, carbon black or a mixture thereof. The rubber stopper for the cephalosporin drug prepared by method disclosed by the invention is good in mechanical strength and good in elasticity, can meet the operating requirements and the processing requirements of the cephalosporin drug rubber stopper, and can also meet the requirements on the contacted liquid drug compatibility after being sealed.

Description

technical field [0001] The invention relates to a chemical material, in particular to a rubber plug material for cephalosporin drugs and a preparation method thereof. Background technique [0002] At present, there are many types of rubber plugs used in the market for cephalosporins, and the materials are various. However, due to the poor material performance of the rubber plug, one or some substances in the interior have the defects of difficult processing and poor sealing performance, and some also release some odors, which will have a certain impact on the user. Contents of the invention [0003] The object of the present invention is exactly in order to solve the deficiency of existing cephalosporins rubber plug material, provide a kind of cephalosporins rubber plug material and preparation method thereof, it can satisfy the use requirement and processing requirement of cephalosporin rubber plug, It can also meet the requirements on the compatibility of the contacted ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08L23/22C08L23/28C08L23/16C08K3/34C08K3/36A61J1/14
CPCC08L23/22C08K2201/014C08L23/283C08L2205/03C08L2207/04C08L23/0815C08L61/06C08K3/34C08K3/36C08L23/083
Inventor 夏汉桥黄爱华张雾云徐小明朱素芳
Owner 应城市恒天药业包装有限公司
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