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Rubber plug material for freeze-dried medicines and preparation method thereof

A technology of rubber stoppers and medicines, applied in the field of chemical materials, can solve problems such as poor sealing performance, poor performance of rubber stoppers, and impact

Inactive Publication Date: 2014-03-19
应城市恒天药业包装有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the poor material performance of the rubber plug, one or some substances in the interior have the defects of difficult processing and poor sealing performance, and some also release some odor, which will have a certain impact on the user.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0011] The invention is prepared by mixing the following raw materials according to weight percentage: 40% of butyl rubber, 20% of ethylene-propylene copolymer, 35% of filler, 3.5% of phenolic resin and 1.5% of coloring agent. The viscosity-average molecular weight of butyl rubber is 80,000, the Mooney viscosity ML1+8 (100°C) is 40 to 70, and the degree of unsaturation is 0.7 to 1.5 mol%. The melting point of ethylene-propylene copolymer is ≤120°C, the Mooney viscosity ML1+4 (100°C) is 40 to 80, partially cross-linked ethylene-propylene elastomer, and propylene grafted ethylene-propylene elastomer. The filler is mixed with clay, talcum powder and white carbon black in a weight ratio of 2:1:1. The preparation method is to knead the above-mentioned materials in a mixer, mix them under the condition of 130°C to 190°C, preferably 140°C to 160°C, and form them by compression molding or injection molding.

Embodiment 2

[0013] The invention is prepared by mixing the following raw materials according to weight percentage: 30% of butyl rubber, 15% of ethylene-propylene copolymer, 50% of filler, 4% of phenolic resin and 1% of coloring agent. The viscosity-average molecular weight of butyl rubber is 80,000, the Mooney viscosity ML1+8 (100°C) is 40 to 70, and the degree of unsaturation is 0.7 to 1.5 mol%. The melting point of ethylene-propylene copolymer is ≤120°C, the Mooney viscosity ML1+4 (100°C) is 40 to 80, partially cross-linked ethylene-propylene elastomer, and propylene grafted ethylene-propylene elastomer. The filler is mixed with clay, talcum powder and white carbon black in a weight ratio of 2:1:1. The preparation method is to knead the above-mentioned materials in a mixer, mix them under the condition of 130°C to 190°C, preferably 140°C to 160°C, and form them by compression molding or injection molding.

Embodiment 3

[0015] The invention is prepared by mixing the following raw materials according to weight percentage: 30% of halogenated butyl rubber, 20% of ethylene-propylene copolymer, 45% of filler, 4.5% of phenolic resin and 0.5% of coloring agent. The Mooney viscosity ML1+8 (100°C) of the halogenated butyl rubber is 40 to 70, the degree of unsaturation is 0.7 to 1.5 mol%, and the weight ratio of the halogen content is 0.5 to 3.0%. The melting point of ethylene-propylene copolymer is ≤120°C, and the Mooney viscosity ML1+4 (100°C) is 40 to 80. The filler is mixed with clay, talcum powder and white carbon black in a weight ratio of 2:1:1. The preparation method is to knead the above-mentioned materials in a mixer, mix them under the condition of 130°C to 190°C, preferably 140°C to 160°C, and form them by compression molding or injection molding.

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Abstract

The invention relates to a chemical material, particularly a rubber plug material for freeze-dried medicines and a preparation method thereof. The rubber plug material is prepared by mixing the following raw materials in percentage by weight: 20-40% of synthetic rubber, 10-20% of thermoplastic elastomer, 30-50% of filler, 3-8.5% of crosslinking agent and 0.5-1.5% of colorant. The synthetic rubber is butyl rubber, polyisobutylene or halogenated butyl rubber; the thermoplastic elastomer is a styryl elastomer or polyolefin thermoplastic elastomer; the filler is one or more of argil, talcum powder and white carbon black; the crosslinking agent is metal oxide or phenol aldehyde resin; and the colorant is titanium white, carbon black or mixture thereof. The rubber plug for freeze-dried medicines has the advantages of favorable mechanical strength and high elasticity, can satisfy the operational requirements and processing requirements for the rubber plug for freeze-dried medicines, and can also satisfy the requirements for medicinal compatibility of the contact liquid after sealing.

Description

technical field [0001] The invention relates to a chemical material, in particular to a rubber plug material for freeze-dried medicine and a preparation method thereof. Background technique [0002] At present, there are many types of rubber stoppers for freeze-dried drugs in the market, and the materials are various. However, due to the poor material performance of the rubber plug, one or some substances in the interior have the defects of difficult processing and poor sealing performance, and some also release some odors, which will have a certain impact on the user. Contents of the invention [0003] The object of the present invention is to solve the deficiency of the existing rubber stopper materials for freeze-dried medicines, and provide a kind of rubber stopper materials for freeze-dried medicines and a preparation method thereof, which can meet the use requirements and requirements of the rubber stoppers for freeze-dried medicines. Processing requirements, and ca...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08L23/22C08L23/28C08L23/16C08K3/34C08K3/36A61J1/14
CPCC08L23/22C08K2201/014C08L23/283C08L2205/03C08L2207/04
Inventor 夏汉桥黄爱华张雾云徐小明朱素芳
Owner 应城市恒天药业包装有限公司
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