Coated chlorobutyl rubber plug and preparation method thereof

A technology of chlorobutyl rubber and film-coated chlorobutyl rubber, which is applied in the field of film-coated chlorobutyl rubber stoppers and its preparation, and can solve the problem of compatibility between rubber stoppers and drugs and the inability to meet the requirements of low shedding , Reduce the self-sealing of rubber plugs and other problems, to achieve the effect of preserving elasticity and sealing, good mechanical strength and elasticity, good mechanical properties and elasticity

Inactive Publication Date: 2019-07-16
应城市恒天药业包装有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, when the rubber stopper comes into contact with the drug solution, the silicone oil on the surface of the rubber stopper will also react with the drug solution, which cannot solve the problem of compatibility between the rubber stopper and the drug, affects the quality of the drug, and cannot meet the requirements of low chip shedding during puncture
Although there is also a method of coating halobutyl rubber plugs at present, the current coated rubber plugs are prone to aging, which will reduce their service life, and the existing coated rubber plugs are also easy to fall off, reducing the original natural properties of the rubber plugs. tightness

Method used

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  • Coated chlorobutyl rubber plug and preparation method thereof
  • Coated chlorobutyl rubber plug and preparation method thereof
  • Coated chlorobutyl rubber plug and preparation method thereof

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preparation example Construction

[0031] The embodiment of the present invention also provides a kind of preparation method of film-coated chlorinated butyl rubber stopper, comprises the steps:

[0032] (1) prepare materials by weight;

[0033] (2) Divide the chlorinated isoprene isobutylene rubber into four parts, mix the first part of the chlorinated isoprene isobutylene rubber with the coloring agent uniformly to obtain product A; mix the activator and filler uniformly to obtain product B ; Mix the second part of chlorinated isoprene isobutylene rubber with crosslinking agent uniformly to obtain product C; mix the third part of chlorinated isoprene isobutylene rubber with activator to obtain product D; After chlorinated isoprene isobutylene rubber and product A are mixed evenly, add 1 / 3 of product B to the above mixed product, mix again, then add 2 / 3 of product B and product C to the above mixed product, mix After uniformity, add product D to the above mixed product and mix uniformly to make a preformed bo...

Embodiment 1

[0040] Embodiment 1 of the present invention provides a film-coated chlorinated butyl rubber stopper, the chlorinated butyl rubber stopper main body includes the following raw materials in parts by weight: 100 parts of chlorinated isoprene isobutylene rubber, 6-(diethyl 0.9 parts of amino)-1,3,5-triazole-2,4-dithiol, 40 parts of white carbon black, 0.15 parts of carbon black, 2 parts of zinc oxide and 0.4 parts of titanate. Among them, isochloride The viscosity-average molecular weight of pentadiene isobutylene rubber is 150,000, the Mooney viscosity ML 1+8 (100°C) is 45, the degree of unsaturation is 1.3mol%, and the content of chlorine is 1wt%; the crown and neck of the main body There is an ethylene-tetrafluoroethylene copolymer film on the top, the melting point of the ethylene-tetrafluoroethylene copolymer is 265 ° C ~ 275 ° C, the continuous working temperature is 150 ° C, the embrittlement temperature is -100 ° C, the ethylene-tetrafluoroethylene copolymer at the crown ...

Embodiment 2

[0047] Embodiment 2 of the present invention provides a film-coated chlorinated butyl rubber stopper, the chlorinated butyl rubber stopper main body includes the following raw materials in parts by weight: 90 parts of chlorinated isoprene isobutylene rubber, 6-(diethyl 0.8 part of amino)-1,3,5-triazole-2,4-dithiol, 30 parts of white carbon black, 0.1 part of carbon black, 1 part of zinc oxide and 0.3 part of titanate. The viscosity-average molecular weight of pentadiene isobutylene rubber is 120,000, the Mooney viscosity ML 1+8 (100°C) is 100, the degree of unsaturation is 3mol%, and the content of chlorine is 3wt%. All are equipped with ethylene-tetrafluoroethylene copolymer film, the melting point of the ethylene-tetrafluoroethylene copolymer is 265 ° C ~ 275 ° C, the continuous working temperature is 150 ° C, the embrittlement temperature is -100 ° C, the ethylene-tetrafluoroethylene copolymer of the crown is The thickness of the fluoroethylene copolymer film is 20um, and t...

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Abstract

The invention discloses a coated chlorobutyl rubber plug. The coated chlorobutyl rubber plug comprises a main body having a crown portion and a plug neck portion, the main body comprises the followingraw materials, in parts by weight: 90-110 parts of chlorinated isoprene isobutylene rubber, 0.8-1 part of a crosslinking agent, 30-50 parts of a filler, 0.1-0.2 part of a coloring agent, 1-3 parts ofan activator, and 0.3-0.5 part of an activation auxiliary agent; and a fluoropolymer film is arranged on the crown portion of the main body. According to the coated chlorobutyl rubber plug provided by the invention, a specific main body material is adopted to be combined with the fluoropolymer film on the crown portion of the main body, so that the chlorobutyl rubber plug has more-excellent comprehensive performance and higher safety, no siloxane-like impurities are precipitated, the product quality is effectively controlled, and medication safety is guaranteed. The invention also provides apreparation method of the coated chlorobutyl rubber plug.

Description

technical field [0001] The invention belongs to the technical field of medical packaging materials, and in particular relates to a film-coated chlorinated butyl rubber stopper and a preparation method thereof. Background technique [0002] Medical rubber stoppers are mainly produced from halogenated butyl rubber (including chlorinated butyl rubber and brominated butyl rubber). Medical rubber stoppers are the main sealing and exporting parts used to encapsulate various bottled drugs such as antibiotics and infusion drugs. During use and storage, they will inevitably come into direct contact with the drugs, and their quality is decisive for the stability of the drugs. effect. Existing studies have shown that when the rubber stopper is in contact with the injection, the rubber stopper may absorb active ingredients, antibacterial preservatives or other substances in the injection, and even cause a chemical reaction to cause the drug to fail; one or more components in the rubber...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08L15/02C08K13/02C08K5/378C08K3/36C08K3/22C08K3/04
CPCC08K3/04C08K3/22C08K3/36C08K5/378C08K13/02C08K2003/2296C08L15/02
Inventor 石雄安夏汉桥黄爱华张雾云
Owner 应城市恒天药业包装有限公司
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