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Novel quadrupole rod-ion trap tandem mass spectrum ion storage system and method

A technology of ion storage and tandem mass spectrometry, which is applied in the field of quadrupole-ion trap tandem mass spectrometry ion storage system, can solve the problems of system sensitivity reduction, waste of ions, and low ion trap duty cycle, so as to improve sensitivity and duty cycle than the effect

Active Publication Date: 2020-11-13
NAT INST OF METROLOGY CHINA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

During analysis, ions generated by the ion source are wasted, resulting in a very low duty cycle of the ion trap and a loss of system sensitivity

Method used

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  • Novel quadrupole rod-ion trap tandem mass spectrum ion storage system and method
  • Novel quadrupole rod-ion trap tandem mass spectrum ion storage system and method
  • Novel quadrupole rod-ion trap tandem mass spectrum ion storage system and method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0050] ion guide storage

[0051] Using reserpine sample, mass-to-ho ratio scanning range m / z 550 to 650, optimize the Q0 voltage in ion guide storage mode, the relationship between Q0 voltage and signal intensity is as follows Figure 5 shown. The optimal value of Q0 storage is -6.1V.

[0052] Using reserpine samples, the mass-to-ho ratio scanning range m / z 550 to 650, compared the traditional ion transmission mode with the ion guidance storage mode, and obtained the relationship between storage time and signal intensity. The experimental results are as follows Image 6 shown.

[0053] It can be seen from the change trend of the signal intensity of the traditional ion transmission mode and the ion guidance storage mode that as the storage time increases, the signal intensity of the two increases first, and after reaching saturation, the intensity tends to be stable. For ion guide storage mode: within 0.03s-0.22s, the intensity increases linearly as Figure 7 , R 2 =0.992...

example 2

[0059] Ion guide and ion trap shared storage

[0060] The ion guide and the ion trap jointly store the sequence as Figure 10 : The quadrupole RF voltage and the ion trap RF voltage are raised from 0V to a constant value in the ionization (ionization) section; Skimmer is set to +5.5V in the entire sequence; Lens1 is set to + in the ionization sequence respectively 10V is reduced to -20V, and Lens2 is reduced from +200V to -20V in the ionization sequence, so that the stored ions enter the ion trap. During the entire quality cycle, Q00 is always -2.5V, Lens0 is always -4.1V, and Q0 is always -6V. In the last six sequences (cooling, cooling1, pre-sample, sample, down, zero), Lens1 is raised from -20V to +10V, and Lens2 is raised from -5.7V to +200V, so that ions can be stored in the ion guide middle.

[0061] Observe that the intensity of the ion guide and ion trap in the common storage mode is as follows: Figure 11 It can be seen that the value of the first point is about 0...

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PUM

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Abstract

The invention discloses a novel quadrupole rod-ion trap tandem mass spectrometry ion storage system and method, and belongs to the technical field of mass spectrometry. The system sequentially comprises a heating capillary tube, a lens cone lens, a sampling cone, a first ion guide, a second ion guide, a quadrupole rod mass analyzer, an ion trap mass analyzer and a detector, wherein a first lens isarranged between the first ion guide and the second ion guide, a second lens and a third lens are arranged between the second ion guide and the quadrupole rod mass analyzer, and the operation modes of the first ion guide and the second ion guide comprise an ion transmission mode and an ion storage mode. Compared with a traditional sequential control method, more ions are stored in the method in the same time, and the sensitivity of the instrument is improved.

Description

technical field [0001] The patent of the invention belongs to the technical field of mass spectrometry, and specifically relates to a quadrupole-ion trap tandem mass spectrometry ion storage system and method. Background technique [0002] Quadrupole ion trap mass spectrometer with full scan, high sensitivity, high resolution scan and MS n Therefore, it is widely used in the field of analytical chemistry. [0003] The quadrupole mass analyzer and the ion trap mass analyzer apply voltage in the same way: the same voltage is applied to opposite electrodes, and the opposite voltage is applied to adjacent electrodes. For the ion trap mass analyzer, a certain RF voltage and DC voltage are applied to form a quadrupole field for trapping ions. However, the structural size of the ion trap itself limits its ion storage capacity. When too many ions are injected, space charge effects will appear in the ion trap, resulting in mass shift and distortion of analysis results. [0004] I...

Claims

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Application Information

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IPC IPC(8): H01J49/42
CPCH01J49/4295H01J49/4205H01J49/4255H01J49/4265H01J49/063H01J49/4225H01J49/004H01J49/067
Inventor 楚士颖江游方向安育廷戴新华张谛黄泽建
Owner NAT INST OF METROLOGY CHINA
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