Method for identifying traditional Chinese medicine quality marker based on analytic hierarchy process-entropy weight method
An analytic hierarchy process and marker technology, applied in the research field of marker components of traditional Chinese medicine, can solve problems such as weak correlation, poor specificity of quality control indicators, poor systematic quality research, etc., and achieve strong operability and good universality performance, a wide range of applications
Pending Publication Date: 2020-11-24
SHAANXI UNIV OF CHINESE MEDICINE
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Problems solved by technology
The weak correlation between quality control indicators of traditional Chinese medicine and the traditional efficacy of traditional Chinese medicine, poor specificity of quality control indicators, poor quality research system, and repetitive research have always been common problems in the quality control and development of the whole process from medicinal materials to finished medicines.
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Embodiment 1
[0036] The method for identifying quality markers of Shaoyao Gancao Decoction based on AHP-entropy weight method includes the following steps:
[0037] (1) Measurable component analysis of Shaoyao Gancao Decoction
[0038] Retrieve experimental research literature on content determination of Radix Paeoniae Alba, Zhigancao and Shaoyao Gancao Decoction. Using "white peony" or "paeoniae radix alba", "roasted licorice" or "glycyrrhizae radix et rhizoma", "Shaoyao Gancao decoction" or "Shaoyao Gancao decotion", "content" or "content" as search terms, included experimental Research literature, as the data of the measurability of Shaoyao Gancao Decoction; the more articles on the content determination of the main ingredients in the white peony root and Zhigancao medicinal materials, the stronger the measurability of the ingredients; the detection methods of ingredients include HPLC, UPLC, UPLC- Q-TOF-MS, etc., count the proportion of HPLC detection methods. If the statistical value ...
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The invention discloses a method for identifying a traditional Chinese medicine quality marker based on an analytic hierarchy process-entropy weight method. The method comprises: carrying out weight analysis on three core quality attributes of effectiveness, testability and specificity of traditional Chinese medicine components by using an analytic hierarchy process; analyzing specific indexes under each attribute based on literature and/or experimental data by applying an entropy weight method; and after obtaining the weight of each specific index, carrying out weighted calculation on the comprehensive score of each component, and sorting, so that three core factors of effectiveness, testability and specificity of traditional Chinese medicine components are integrated, a quality marker system evaluation system is constructed, the traditional Chinese medicine quality marker quantitative identification method based on analytic hierarchy process-entropy weight method comprehensive evaluation is established and is successfully applied to research of the classic famous prescription peony and liquorice soup quality marker, a new method is provided for quantitative evaluation and accurate identification of the traditional Chinese medicine quality marker, and an important support is provided for powerfully improving the traditional Chinese medicine quality control level.
Description
technical field [0001] The invention relates to a method for researching marker components of traditional Chinese medicine, in particular to a method for identifying quality markers of traditional Chinese medicine based on analytic hierarchy process-entropy weight method. Background technique [0002] The quality of Chinese medicine is the lifeline to ensure the sustainable development of the Chinese medicine industry, and the research and application of quality standards for Chinese medicine is a national strategic issue related to the development of Chinese medicine science and industry [1]. The research on the quality of traditional Chinese medicine is a complex systematic project. In recent years, although the level of research on the quality of traditional Chinese medicine has made great progress, it still fails to meet the people's ever-increasing requirements for quality safety and controllability. "The Pharmacopoeia of the People's Republic of China" is the basis of ...
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IPC IPC(8): G16C20/50G16C20/20G16C20/70
CPCG16C20/20G16C20/50G16C20/70
Inventor 陈艳琰冯利梅唐于平
Owner SHAANXI UNIV OF CHINESE MEDICINE
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