Liquid phase mass spectrum sampling and electrospray combined device

A combined device and electrospray technology, applied in the field of analytical instruments, can solve the problems of unstable signal and low ionization efficiency, and achieve the effects of stable signal, sensitive mass spectrometry analysis, and fast needle washing.

Pending Publication Date: 2020-12-08
GUANGDONG RANGER BIOSCI CO LTD
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] The purpose of the embodiments of the present invention is to provide a combined device for sample dipping, transportation and electrospray in liquid phase mass spectrometry, aiming to solve the problems of unstable signal and low ionization efficiency of existing liquid phase mass spectrometers

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  • Liquid phase mass spectrum sampling and electrospray combined device
  • Liquid phase mass spectrum sampling and electrospray combined device
  • Liquid phase mass spectrum sampling and electrospray combined device

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Embodiment Construction

[0033] In order to make the technical problems, technical solutions and beneficial effects to be solved by the present invention clearer, the present invention will be further described in detail below in conjunction with the accompanying drawings and embodiments. It should be understood that the specific embodiments described here are only used to explain the present invention, not to limit the present invention.

[0034] Such as figure 1 As shown, the present invention provides a combined device for direct sampling and ionization of liquid phase mass spectrometry, including a sampling mechanical arm 1, a sample tray 2, a sampling needle seat 3, a high voltage connector 4, a multifunctional probe for sampling and sampling Needle 5, ion source sealed cavity 6 and mass spectrometer inlet 7, wherein the sample tray is used to store the sample to be tested or the standard sample; the sample injection needle seat 3 is arranged at the end of the sample injection mechanical arm 1 (m...

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Abstract

The invention is applicable to the field of analytical instruments, and provides a sampling and sample introduction multifunctional probe for liquid mass spectrometry electrospray, which comprises a probe body and a tip part, the tip part is formed by continuous contraction of the whole or part of the probe body, and the tip part is provided with a solution carrying structure. The invention further provides a liquid phase mass spectrum sampling and electrospray combined device comprising the multifunctional probe. The liquid phase mass spectrum sampling and electrospray combined device comprises a sample injection mechanical arm, a sample injection needle seat and an ion source sealing cavity. The ion source provided by the invention is also a sampling needle, has the characteristics of small sampling amount (about 0.1-10mu L) and high needle washing speed, and compared with the traditional sample injection mode, a needle pump and a sample injection valve are omitted, so that the stability and the detection sensitivity are greatly improved.

Description

technical field [0001] The invention belongs to the field of analytical instruments, and in particular relates to a multifunctional probe for directly dipping samples and performing electrospray ionization on the samples, and a combination device of liquid phase mass spectrometry sampling and electrospray. Background technique [0002] Liquid phase mass spectrometer is one of the most advanced chemical analysis instruments at present, and guides the development direction of analytical instruments. As the most basic functional part of a mass spectrometer system, the ion source determines the sensitivity, accuracy and application range of the mass spectrometer to a large extent. At present, the electrospray ion source is the most widely used ion source in liquid mass spectrometry. Its application scope includes the analysis and detection of biological macromolecules and inorganic and organic small molecules, opening up a new era of modern mass spectrometry. [0003] The exist...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/02G01N30/24G01N30/72
CPCG01N30/02G01N30/24G01N30/72H01J49/165G01N2035/1037G01N35/1079G01N35/1083G01N30/7266H01J49/0445
Inventor 朱建雄
Owner GUANGDONG RANGER BIOSCI CO LTD
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