A kind of HPLC fingerprint detection method of Xiaojin preparation

A fingerprint and detection method technology, which is applied in the field of HPLC fingerprint detection of Xiaojin preparations, can solve the problems of inability to fully control the quality of traditional Chinese medicine compound, and achieve the effects of high efficiency, high selectivity and fast analysis speed

Active Publication Date: 2020-07-10
JIANMIN PHARMA GRP CO LTD
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  • Abstract
  • Description
  • Claims
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Problems solved by technology

[0005] In view of the fact that the current quality detection method for Xiaojin preparations cannot fully control the quality of compound Chinese medicines, the purpose of the present invention is to establish an HPLC fingerprint detection method for Xiaojin preparations

Method used

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  • A kind of HPLC fingerprint detection method of Xiaojin preparation
  • A kind of HPLC fingerprint detection method of Xiaojin preparation
  • A kind of HPLC fingerprint detection method of Xiaojin preparation

Examples

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Embodiment Construction

[0034] Below, taking Xiaojin Capsule as an example, the present invention will be described in detail through specific examples.

[0035] The Xiaojin capsules used in the following examples are provided by Jianmin Pharmaceutical Group Co., Ltd. Artificial musk 30g, wood turtle 150g, aconitum 150g, sweetgum balm 150g, frankincense 75g, myrrh 75g, wulingzhi 150g, angelica 75g, earthworm 150g, incense ink 12g, crushed and filled with capsules.

[0036] 1. Instruments and reagents

[0037] Waters e2695 high performance liquid chromatography, quaternary pump, online vacuum degassing system, automatic sampler, column thermostat, ultraviolet detector; AB204-E electronic balance (Shanghai Mettler-Toledo Instrument Co., Ltd.).

[0038] 10 batches of Xiaojin Capsules (170116-0121, 170332-0335, 10 batches in total); methanol is chromatography grade, and water is purified water.

[0039] 2. Method steps

[0040] (1) Preparation of the test solution: take the content of Xiaojin Capsules...

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Abstract

The invention discloses a traditional Chinese medicine fingerprint spectrum detection method of a Xiaojin preparation. By screening conditions of instruments, chromatographic columns, mobile phase, detection wavelength and the like, liquid phase fingerprint spectrum determination conditions are established and methodological observation is conducted, and fingerprint spectrum standard of the Xiaojin preparation is established according to a plurality of batches of mass-production samples. As the formula of the product contains medicinal herb sources of vegetable drugs, animal drugs, resins andthe like, medicinal material sources are wide, origin places are numerous, the good and bad are intermingled, and the limit of low quality standard exists, so that in order to further improve the quality of the products and ensure the medicine safety and efficacy, the medicinal material sources of the Xiaojin preparation is about to be controlled, fingerprint spectrum is adopted to be capable of comprehensively and effectively controlling the quality of the products, the all-process production quality control system can be established, and the quality tracibility system running through a fullindustry chain can be established on the basis.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine detection, and relates to an HPLC fingerprint detection method of Xiaojin preparation. Background technique [0002] The fingerprint of traditional Chinese medicine is a quality control mode of traditional Chinese medicine developed based on the common similarity of Chinese medicinal material groups and with the help of various spectroscopy, spectrum, chromatography and other technologies. Traditional Chinese medicine fingerprint refers to the spectrum of common peaks that can mark the characteristics of the traditional Chinese medicine obtained after proper processing of traditional Chinese medicine by using certain analytical methods, so as to identify the authenticity and evaluate the uniformity and stability of the quality of the medicinal material. Within a certain range, the fingerprint of traditional Chinese medicine can basically reflect the whole picture of traditional Chinese ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N30/02G01N30/06G01N30/74
CPCG01N30/02G01N30/06G01N30/74
Inventor 李霞赵洋黄志军吴木琴向阳赵刚熊登科朱立彬童懿
Owner JIANMIN PHARMA GRP CO LTD
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