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Application of sulfur in preparation of composition for increasing testosterone level or improving intestinal flora

A technology of intestinal flora and composition, applied in the field of pharmacy

Active Publication Date: 2020-12-29
上海市生物医药技术研究院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Furthermore, despite rising incidence, the diagnosis and treatment of TD remains a challenge for clinicians because only 12% of men with TD have clinically symptomatic, hypogonadal symptoms because symptoms are nonspecific and variable. of men successfully treated with TST

Method used

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  • Application of sulfur in preparation of composition for increasing testosterone level or improving intestinal flora
  • Application of sulfur in preparation of composition for increasing testosterone level or improving intestinal flora
  • Application of sulfur in preparation of composition for increasing testosterone level or improving intestinal flora

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0082] The analysis of heavy metal content in embodiment 1, sulfur

[0083] The purity of the sulfur used in the subsequent examples reaches 99%. According to the 2015 edition of the Chinese Pharmacopoeia, the four general rules 0821 heavy metal inspection method (the second method), the trace heavy metals in it were determined, and a mature analysis method was established.

[0084] The results showed that the heavy metal content of all the sulfur preparation samples met the national standard, so it can be used in animal experiments and traditional Chinese medicine preparations.

Embodiment 2

[0085] Embodiment 2, sulfur feeding male mouse and treatment method

[0086] Eighty 6- to 7-week-old male Kunming mice were randomly divided into two groups, 40 in each group, which were the control group and the treatment group. After the mice were purchased, they were fed for one week to reduce stress, and the experiment began after they adapted to the environment. The mice of the control group were intragastrically administered with 0.2ml distilled water every day, 6 times a week (stopping 1 day after every 6 days), and continued for one month; 250mg / kg (sulfur dosage / mouse body weight), once a day, 6 times a week (stop 1 day after every 6 days), for 30 days.

[0087] Blood collection from the heart: After the mouse was anesthetized by intraperitoneal injection of 5% chloral hydrate at a dose of 100 μl / 10g body weight, the abdominal cavity was opened, and a 1ml syringe was inserted into the heart valve at a 45-degree angle to draw blood. About 1ml of whole blood was colle...

Embodiment 3

[0092] Embodiment 3, the impact of sulfur on male mouse serum and serum testosterone levels

[0093] 1. Effect of sulfur on serum and serum testosterone levels in male mice

[0094] Male Kunming mice were fed with sulfur for 1 month by the method described in Example 2, and serum was collected to detect serum testosterone levels using a testosterone detection kit from R&Dsystem Company according to the instructions. like figure 1 As shown, the serum testosterone level of Kunming mice after oral administration of sulfur (250mg / kg) for 1 month was 7.661±1.313ng / ml, the serum testosterone level of control group mice was 2.633±0.610ng / ml, and the sulfur treatment group was the control group 2.9 times (p<0.01).

[0095] The feces of the mice were taken, homogenized with the diluent in the kit, left overnight at 4°C, and the supernatant was taken to detect the testosterone level. like figure 2 As shown, the testosterone level of Kunming mice after oral administration of sulfur ...

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Abstract

The present invention relates to an application of sulfur in preparation of a composition for increasing testosterone level or improving intestinal flora. The invention reveals for the first time thatthe sulfur has the effects of increasing the testosterone level and improving the intestinal flora. The invention provides a new way for researching a new medicine for improving the androgen level and a new medicine for improving the intestinal flora.

Description

technical field [0001] The invention belongs to the field of pharmacy, and more specifically, the invention relates to the use of sulfur in preparing compositions for improving testosterone levels or improving intestinal flora. Background technique [0002] Testosterone plays a key role in the regulation of adult male reproductive health, sexual function, bone health, fat metabolism, muscle mass and strength. A large number of studies have shown that after the age of 30, the level of bioavailable testosterone in men decreases linearly every year. With the decline of testosterone levels, 13% of men further develop pathological symptoms in terms of physical, sexual and cognitive functions, such as bone and muscle Decreased quality, hypogonadism, emotional depression and cognitive impairment, etc., the inventors call it testosterone deficiency (TD), or hypogonadism. [0003] Testosterone supplementation therapy (TST) can effectively alleviate the symptoms of TD and improve the...

Claims

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Application Information

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IPC IPC(8): A61K33/04A61P1/00A61P15/08A61P5/26
CPCA61K33/04A61P1/00A61P15/08A61P5/26
Inventor 李润生陈良康李元春郑华军
Owner 上海市生物医药技术研究院
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