10 results about "Testosterone level" patented technology

This invention belongs to the field of biomedical technology, specifically relating to the application of a composition in the preparation of a drug for the prevention and treatment of polycystic ovary syndrome (PCOS). The composition comprises bovine spleen peptide and adenosine; the mass ratio of bovine spleen peptide to adenosine is 1:(1-2.5). Bovine spleen peptide, as a bioactive polypeptide, significantly improves insulin resistance associated with PCOS by targeting and activating the PI3K-Akt signaling pathway and promoting insulin receptor substrate phosphorylation. Adenosine, as a natural bioactive substance, significantly reduces serum luteinizing hormone and testosterone levels in rats and increases follicle-stimulating hormone levels, thereby effectively alleviating hyperandrogenism symptoms such as hirsutism and acne in PCOS. Furthermore, this composition can significantly improve polycystic pathological changes in the ovarian tissue of model rats, reduce the number of cystic dilated follicles, restore the granulosa cell layer structure, alleviate ovarian stromal hyperplasia, and promote normal follicular development.

The invention discloses application of cubilose in preparation of a product for improving polycystic ovarian syndrome. The cubilose can effectively improve the hormone level of a patient with the polycystic ovarian syndrome, remarkably improve the levels of follicle-stimulating hormone and estradiol, reduce the levels of luteinizing hormone and testosterone and reduce the ratio of the content of the luteinizing hormone to the content of the follicle-stimulating hormone.

This invention discloses a total phenolic amine from bee pollen, its preparation method, and its application in alleviating zearalenone (ZEA) toxicity, belonging to the field of agricultural technology. The total phenolic amines extracted from bee pollen by this invention can reduce the bioaccumulation of ZEA and alleviate organ pathological damage; it can inhibit lipid peroxidation by activating the Nrf2 / GPX4 signaling pathway, upregulate BTB core protein, and restore the integrity of the barrier function; furthermore, TPP can regulate sex hormone balance, reverse the ZEA-induced decrease in testosterone levels and abnormal increase in estradiol, thereby comprehensively alleviating the toxic effects of ZEA.

The present disclosure describes a GnRH therapeutic for neutralizing GnRH levels in subjects which can reduce testosterone levels to attenuate or eliminate prostate cancer cell growth and / or metastasis. The therapeutic is produced synthetically. The GnRH therapeutic includes a hapten carrier (hC) comprising a monomeric peptide (MP), synthesized separately from the GnRH peptide, and following self-assembly of the hC, GnRH is covalently coupled to form a GnRH-hC conjugate which can serve as a therapeutic. The MP includes heptad repeats following a specific pattern. The hC can include a GnRH peptide attached to a monomeric peptide prior to self-assembly to form a therapeutic. Optionally, the GnRH-hC conjugate further includes one or more T-cell epitopes at the N- and / or C-terminus of the one or more amphipathic alpha-helices. The present disclosure also describes compositions including immunogenic compositions including the therapeutics described herein.

The invention discloses bee pollen total phenol amines, a preparation method and application of the bee pollen total phenol amines in relieving toxicity of zearalenone, and belongs to the technical field of agriculture. According to the bee pollen total phenol amine extracted by the method, the biological accumulation of ZEA can be reduced, and the pathological injury of visceral organs can be relieved; a lipid peroxidation reaction is inhibited by activating an Nrf2 / GPX4 signal channel, BTB core protein is up-regulated, and the integrity of a barrier function is recovered; in addition, the TPP can regulate sex hormone balance and reverse testosterone level decrease and estradiol abnormal increase induced by the ZEA, so that the toxic effect of the ZEA is comprehensively relieved.

The present application provides a polypeptide composition and its use in treating male erectile dysfunction. Specifically, the polypeptide composition contains an erectile peptide screened and identified by the present application, which has good anti-oxidation and anti-fatigue properties, can effectively promote penile erection, increase testosterone level, effectively treat erectile dysfunction, and has a wide application prospect.

The invention relates to an application of interleukin IL-27 in preparation of a medicine for improving an individual testosterone secretion level, and compared with the prior art, the application has the following advantages that the interleukin IL-27 is taken as an entry point, an IL-27mRNA-LNP therapy is creatively applied to a brand new indication for improving an endogenous testosterone level, and the application has a wide application prospect. The research finds and verifies for the first time that the IL-27 protein with biological activity can be successfully expressed through subcutaneous injection of IL-27mRNA-LNP, and the IL-27 protein acts on the center and the periphery at the same time, so that a brand-new and safer potential treatment scheme is provided for treating testosterone deficiency; the application boundary of biological function cognition of the IL-27 and the mRNA-LNP technology is expanded, and important scientific significance and clinical transformation value are achieved.

The present application belongs to the field of biological health care products and food processing technology, and relates to a testosterone inducing liquid of Rana spinosa, testosterone-enriched Rana spinosa polypeptide, and a preparation method and application thereof. The present application carries out multi-disciplinary and multi-factor intervention experiments on Rana spinosa in the breeding period, explores the estrus information substance of Rana spinosa, finds an effective method for stimulating the estrus of Rana spinosa in the breeding period by using the information substance of female frogs, and facilitates the production and application of raw materials, thereby creating a new path for the development of functional products of Rana spinosa. Through artificial intervention and induction, the testosterone content of Rana spinosa in the breeding period is synchronously increased, and the testosterone level is more than twice that of the control group. The present application further provides a production process for extracting polypeptide from Rana spinosa, including the steps of raw material storage, enzymolysis, fermentation, centrifugation, drying, and the like, and finally obtaining a testosterone-enriched polypeptide product. The product can be applied to the fields of food, health care products, and medicine, and has the potential to improve the economic value of Rana spinosa.

The invention discloses an intestinal bacterium for improving semen quality and application thereof, and belongs to the field of microbial technology and biological medicine. In order to solve the problem that in the prior art, specific probiotics are not used for improving male reproductive injury induced by high fat diet, the invention provides a method for applying the allobacter faecalis strain (A.s) or an inactivated form (P-A.s) of the allobacter faecalis strain (A.s) to the male reproductive injury. Animal experiments show that compared with a high fat diet model group, supplementation of A.s or P-A.s can significantly inhibit abnormal weight growth, improve testis index, improve sperm density, vitality, movement speed and testicular testosterone level, and can effectively repair tissue form damage of testis and epididymis and abnormal sperm ultrastructure. Wherein the improvement effect of the inactivated bacterium form P-A.s is particularly prominent.

The invention discloses a method for modifying human umbilical cord mesenchymal stem cells through nitric oxide synthase genes and application of the human umbilical cord mesenchymal stem cells. According to the method, the mesenchymal stem cells are modified by constructing a recombinant retroviral vector carrying a specific nitric oxide synthase gene (SEQ ID NO.1) and transfecting UCMSCs, so that the modified mesenchymal stem cells have remarkable effects in the aspects of repairing the penile erection function, improving the testosterone level and the like, and can be used for treating diabetic penile erection dysfunction.