A kind of eutectic of 5-fluorouracil and kaempferol and preparation method thereof

A technology of fluorouracil and kaempferol, which is applied in the field of medicinal chemistry, can solve the problems of poor solubility of kaempferol, low oral bioavailability, and limited potential of active anti-tumor drugs, and achieve good reproducibility, easy control of the crystallization process, and improved preparations compatibility effect
CN112209887BActive Publication Date: 2021-09-03TIANJIN UNIVERSITY OF TECHNOLOGY +1
4 Cites 0 Cited by

Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
TIANJIN UNIVERSITY OF TECHNOLOGY
Publication Date
2021-09-03

Smart Images

  • Figure 1
    Figure 1
  • Figure 2
    Figure 2
  • Figure 3
    Figure 3
Patent Text Reader

Abstract

The invention discloses a co-crystal of 5-fluorouracil and kaempferol and a preparation method thereof. The molar ratio of 5-fluorouracil and kaempferol in the eutectic is 1:1, and the X-ray powder diffraction pattern of the eutectic is 12.2±0.2°, 13.9±0.2°, 14.8±0.2°, 16.5±0.2°, There are characteristic peaks at 17.5±0.2° and 26.7±0.2°. The eutectic preparation method provided by the invention has simple process, easy control of the crystallization process, good reproducibility, and is suitable for industrial production. This co-crystal can effectively reduce the hygroscopicity of kaempferol, optimize the dissolution properties of 5-fluorouracil and kaempferol, reduce the difference in solubility between the two, improve the compatibility of the preparations of the two drugs, and provide better performance for the two drugs. Anti-tumor synergy provides a research basis.
Need to check novelty before this filing date? Find Prior Art

Description

technical field

[0001] The invention relates to the technical field of medicinal chemistry, in particular to a co-crystal of 5-fluorouracil and kaempferol and a preparation method thereof. Background technique

[0002] Pharmaceutical active ingredients usually exist in crystalline forms, such as polymorphs, hydrates, solvates, salts, and co-crystals. Pharmaceutical co-crystals refer to crystalline substances in which active pharmaceutical ingredients and co-crystal formers are combined in the same crystal lattice in a fixed stoichiometric ratio through non-covalent interactions. The formation of co-crystals can adjust the physicochemical properties of drugs, including solubility, dissolution rate, bioavailability, stability, tabletability, etc., without changing the chemical structure. The co-crystal formed by the active ingredients of two drugs is also called drug-drug co-crystal, which can not only improve the physical and chemical properties of the two drugs at the same ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More