A kind of eutectic of 5-fluorouracil and kaempferol and preparation method thereof
A technology of fluorouracil and kaempferol, which is applied in the field of medicinal chemistry, can solve the problems of poor solubility of kaempferol, low oral bioavailability, and limited potential of active anti-tumor drugs, and achieve good reproducibility, easy control of the crystallization process, and improved preparations compatibility effect
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Embodiment 1
[0046] Weigh 1.30 g of 5-fluorouracil and 2.86 g of kaempferol, add 30 ml of absolute ethanol to obtain a suspension, stir the suspension at room temperature for 5 hours, filter, and dry the resulting white solid at 40°C to obtain 5- A solid sample of co-crystal of fluorouracil and kaempferol, the yield is 83.3%.
Embodiment 2
[0048] Weigh 32.5 mg of 5-fluorouracil and 71.6 mg of kaempferol, add 1 ml of methyl acetate to obtain a suspension, stir the suspension at room temperature for 12 hours, filter, and dry the obtained white solid at 40°C to obtain 5- Solid sample of co-crystal of fluorouracil and kaempferol.
Embodiment 3
[0050] Weigh 13.0 mg of 5-fluorouracil and 28.6 mg of kaempferol, add them to a ball mill jar, then add 20 microliters of ethyl acetate, grind at a frequency of 20 Hz for 60 minutes, and dry the resulting white solid at 40°C to obtain 5-fluorouracil and kaempferol Eutectic solid samples.
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