Female premature ovarian failure susceptibility gene detection model and detection kit

Abstract

The application discloses a female premature ovarian failure susceptibility gene detection model and detection kit. The female premature ovarian failure susceptibility gene detection model disclosed by the application consists of SNP loci of fifteen genes including ELN, SOD2, FSHR, DENND1A, IL17RD, FGF8, KAL1, THADA, LHCGR, FGFR1, GLO1, BMP15, KISS1R, ESR1 and CAT. According to the application, the gene detection model especially for Chinese females is initiatively established, and has race specificity. Moreover, a detection reagent and a kit which are researched and developed according to thegene detection model disclosed by the application can be used for carrying out accurate, sensitive and specific detection on the premature ovarian failure of Chinese females; and a new approach and scheme are provided for premature ovarian failure detection of Chinese females.

Description

technical field

[0001] The application relates to the field of detection of female premature ovarian failure, in particular to a detection model and a detection kit for female premature ovarian failure susceptibility genes. Background technique

[0002] Premature ovarian failure (POF) refers to ovarian failure due to a variety of causes in women before the age of 40, leading to symptoms such as increased levels of follicle-stimulating hormone and decreased levels of estrogen, and most of them manifest as amenorrhea before the age of 40. Premature ovarian failure is one of the most common gynecological diseases in the world today. It is also a common and frequently-occurring disease of the female reproductive system. Its incidence is increasing year by year, causing serious harm to women's reproductive health and society. Research shows that the incidence of premature ovarian failure in China is relatively high, which not only causes amenorrhea, infertility and other reproduc...

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