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HIV treatment compositions and methods

A technology of vaccine composition and derivatives, applied in the field of latent virus infection composition, which can solve the problem that the continuous clearance of ALT-803 latent HIV reservoir is not effective

Pending Publication Date: 2021-02-05
NANTCELL INC
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, although generally well tolerated, ALT-803 is also less effective at producing sustained clearance of latent HIV reservoirs

Method used

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  • HIV treatment compositions and methods
  • HIV treatment compositions and methods
  • HIV treatment compositions and methods

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Embodiment

[0052] ALT-803 stimulation of immune competent cells: as from image 3 It can be easily seen that ALT803 significantly increased the activities of CD4+ T cells, CD8+ T cells and NK cells. image 3 Proliferation (Ki67) and activation (CD69) of CD4, CD8 and NK cells after each administration is depicted. Baseline = Baseline / Dose 1 Pre. Dose 1 is 24 hours after the first dose. Dose 2 was 24 hours after the second dose. Dose 3 was 24 hours after the third dose. LN and PBMC were obtained 48 hours after the third administration. Cytometry data were obtained from frozen samples at each time point indicated.

[0053] Viral protein expression: Figure 4 shows the mean frequency and SEM of HIV transcriptional events in 8 participants before and after stimulation with (A) ALT-803 or (B) concanavalin A. Inducible cell-associated HIV RNA was measured using a next-generation sequencing (NGS)-based protocol called EDITS (Envelope Detection by Induced Transcription-based Sequencing). Be...

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Abstract

HIV treatment, and especially treatment of latent infected CD4 cells, can be significantly improved using a kick-and-kill approach that employs an immune stimulation component and / or HDAC inhibition as one treatment component, and that may also include a second component in which a vaccine composition, various NK cells, CAR-T cells, and / or broadly neutralizing antibodies are administered.

Description

[0001] This application claims priority to our U.S. Provisional Patent Application Serial No. 62 / 686,846 filed June 19, 2018. technical field [0002] The field of the invention is compositions and methods of latent viral infection, and in particular latent infection by HIV. Background technique [0003] The following description includes information useful for understanding the present invention. It is not an admission that any of the information provided herein is prior art or relevant to the presently claimed invention, nor is any publication specifically or implicitly referenced to be prior art. [0004] Although many antiretroviral drug treatments effectively suppress HIV replication, unfortunately, they are not effective in curing the infection. The root cause of this inability to eradicate the virus is in the long-lived resting memory CD4 + A latent infection is established in T cells. Thus, current antiviral therapies will lead to rapid viral rebound and disease ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12N5/0783A61K39/21A61K39/395A61K39/00
CPCA61K31/167A61K31/192A61K31/215A61K31/4045A61K31/4406A61K31/506A61K38/2086A61K38/1793C07K2319/30C07K2317/732C07K16/10C07K16/1045A61K2039/507C07K2317/76A61K35/17A61K47/68A61K39/39A61P31/18Y02A50/30A61K2300/00C07K16/1063C07K14/70535A61K39/12
Inventor 凯文·尼亚齐杰弗里·萨夫瑞特约翰·H·李
Owner NANTCELL INC
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