Application of lauric acid in preparation of hepatic tumor resisting preparation

A technology for lauric acid and liver tumors, applied in the direction of antineoplastic drugs, anhydride/acid/halide active ingredients, drug combinations, etc., can solve the problems of no research and application

Inactive Publication Date: 2021-02-19
HENAN UNIV OF SCI & TECH
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, whether the organic acid can rely on the mechanism of oxidative damage to inhibit the proliferation of liver cancer cells has not been studied and applied so far.

Method used

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  • Application of lauric acid in preparation of hepatic tumor resisting preparation
  • Application of lauric acid in preparation of hepatic tumor resisting preparation
  • Application of lauric acid in preparation of hepatic tumor resisting preparation

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Experimental program
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Effect test

Embodiment

[0019] In vitro cell experiments were used to detect the role of medium-chain fatty acids in inducing apoptosis of liver cancer cells through oxidative damage pathways. Lauric acid can specifically induce the generation of free radicals in liver cancer cells, and the generated free radicals further damage the structure of mitochondria, thereby causing liver cancer. Apoptosis of cells.

[0020] 1. Test drugs and reagents: lauric acid, purchased from Shanghai McLean Biotechnology Co., Ltd., produced by Canada MAKLIN Company, weighed 0.8g lauric acid and added it to 1mL absolute ethanol to make a 4mol / L mother solution; CCK8 detection kit , produced for Biosharp biological company; BCA protein detection kit, produced for Solarbio biological company; total superoxide dismutase (T-SOD) detection kit, reduced glutathione (GSH) detection kit, reactive oxygen species ( ROS), BCA protein detection kit and apoptosis mitochondrial membrane potential detection (ROS), all produced by Nanji...

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Abstract

The invention relates to application of lauric acid in preparation of a hepatic tumor resisting preparation and belongs to the technical field of biomedicines. The lauric acid has an oxidated injury action on hepatic carcinoma cells, the proliferation of the hepatic carcinoma cells is inhibited through oxidated injury, and the oxidated injury is induced by free radicals and is mitochondrion membrane potential destruction induced by the free radicals, so that the activity of T-SOD and a GSH level in the oxidated-injured hepatic carcinoma cells are lowered, and a ROS level in the oxidated-injured hepatic carcinoma cells is increased. Therefore, medium-chain-fatty-acid lauric acid can serve as a hepatic tumor resisting substance and is matched with related drugs so as to promote the oxidatedinjury of the hepatic carcinoma cells and induce the apoptosis of the hepatic carcinoma cells, and thus, the action of inhibiting a hepatic tumor from developing is achieved.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and in particular relates to the application of lauric acid in the preparation of anti-hepatic tumor preparations. Background technique [0002] The liver is the largest solid organ in the body and is responsible for a variety of important physiological functions. When the liver function is out of balance, it will cause various liver diseases such as fatty liver, liver fibrosis, liver cancer, and acute liver necrosis. Among various liver diseases, hepatocellular carcinoma (hepatocellular carcinoma, referred to as liver cancer) is known as the "king of cancer". Liver cancer originates from mature liver cells and is the end-stage manifestation of liver diseases such as fatty liver, cirrhosis, and viral hepatitis. Liver cancer threatens people's health with high morbidity and mortality, and has become the third largest digestive system malignancy after gastric cancer and esophageal cancer. Due...

Claims

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Application Information

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IPC IPC(8): A61K31/20A61P35/00
CPCA61K31/20A61P35/00
Inventor 陈晓光刘玉梅吕琼霞位治国朱雪敏张自强
Owner HENAN UNIV OF SCI & TECH
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