Silica nanoreactor capable of releasing oxygen and active oxygen in pH response and preparation method thereof

A nano-reactor and silicon oxide technology, applied in the field of medical materials, can solve problems such as imperfect electron transfer system, lack of mitochondria and microbodies, and lack of antioxidant enzymes

Active Publication Date: 2021-05-18
SHANGHAI NINTH PEOPLES HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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  • Abstract
  • Description
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Problems solved by technology

[0003] On the other hand, the lack of mitochondria and microsomes in the structure of tumor cells, functionally, the electron transfer system for generating ATP is not perfect, and various antioxidant enzymes are missing, all of which make tumor cells in a primitive, anaerobic fermentation state. Solution-dominated metabolic status

Method used

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  • Silica nanoreactor capable of releasing oxygen and active oxygen in pH response and preparation method thereof
  • Silica nanoreactor capable of releasing oxygen and active oxygen in pH response and preparation method thereof

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Embodiment 1

[0022] A kind of Na provided by the invention 2 CO 3 •H 2 o 2 @HMS-Fe 3 o 4 The preparation method of the composite material is as follows:

[0023] 1. Preparation of composite mesoporous silica nanoparticles (HMS):

[0024] Dissolve 2 g of cetyltrimethylammonium chloride and 0.08 g of triethanolamine in 20 mL of deionized water, heat and stir to 95°C. Then 1 g of ethyl orthosilicate was added dropwise to the above solution, and the stirring was continued for 1 h. Then, a mixed solution of 1 g tetraethoxyethyl orthosilicate and 2 g bis-[3-(triethoxysilyl)propyl]-tetrasulfide was added to the above solution, and the stirring was continued for 4 h. Afterwards, after centrifugation, washing with water and alcohol, and removing the surfactant in the mesopores with an acidic ethanol solution, the composite mesoporous silica nanoparticles HMS can be obtained.

[0025] In the present invention, cetyltrimethylammonium chloride CTAC is first used as a surfactant, and CTAC is us...

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Abstract

The invention discloses a silicon oxide nano-reactor capable of releasing oxygen and active oxygen in a pH-responsive manner and a preparation method thereof. The method comprises: step 1, preparing H@HMS, which comprises: step 1.1, adding Na 2 CO 3 Dissolve in deionized water, add stabilizer, stir evenly, and then add HMS to disperse the HMS uniformly; Step 1.2, add aminotrimethylenephosphonic acid to the aqueous hydrogen peroxide solution and stir evenly, then slowly add to the above HMS to disperse In the homogeneous solution, stir for 1.5-3h; H@HMS is obtained after treatment; Step 2, the above-mentioned H@HMS is dispersed in n-hexane, iron oxide nanoparticles are added, stirred for 12h, and H-HMS-Fe is obtained after treatment. The H-HMS-Fe prepared by the invention can slowly release oxygen in a neutral environment, and can improve the hypoxic microenvironment of malignant solid tumors; in a weakly acidic microenvironment, release hydroxyl radicals to achieve oxidative properties to tumor cells It can be used for targeted therapy to improve the curative effect of solid tumors, and has a good application prospect.

Description

technical field [0001] The invention belongs to the field of medical materials, and in particular relates to a silicon oxide nano-reactor capable of releasing oxygen and active oxygen in response to pH and a preparation method thereof. Background technique [0002] The hypoxic microenvironment is an important feature of solid tumors. Under hypoxic conditions, tumor cells secrete a variety of angiogenic growth factors to promote the formation of abnormal blood vessels. At the same time, in order to find a more suitable soil, the invasion and metastasis ability of tumor cells will be further improved. In addition, the hypoxic microenvironment further enhances the malignancy of tumors, making tumor cells insensitive to chemotherapeutic drugs or radiation therapy. The hypoxic microenvironment is an important factor for the poor prognosis of tumors. Improving the tumor hypoxic microenvironment is expected to become a new method to improve the efficacy of solid tumors. [0003...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/02A61K9/51A61K33/00A61P35/00
CPCA61K9/5115A61K33/00A61P35/00
Inventor 郝永强符静珂贺超
Owner SHANGHAI NINTH PEOPLES HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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