Repair and desensitization injection and preparation method thereof

A sensitivity injection and a technology for injection, applied in the field of repairing and reducing sensitivity injection and its preparation, can solve the problems of many adverse reactions, reduce the sensitivity of the glans, and the adverse consequences of surgery, achieve good therapeutic effect and reduce the sensitivity of the penis , Facilitate the effect of large-scale output

Pending Publication Date: 2021-06-04
河南省九转九天生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The theory of penile dorsal neurotomy originates from the "penile hypersensitivity theory", which believes that blocking the conduction of some nerve fibers can reduce the sensitivity of the glans, thereby prolonging the intravaginalejaculatory latency time (IELT) and improving the clinical symptoms of PE , but it has been confirmed by a large number of clinical studies that the total effective rate of dorsal penis neurotomy is only 73.2%, which is not suitable for all PE patients. The treatment method has high limitations, and there are many postoperative adverse reactions. 8.1% of total PE patients undergoing dorsal penile neurotomy (References: Tullii RE, Guillaux CH, Vaccari R, et al. Premature ejaculation-selective neurectomy: a new therapeutic technique-base, indications and results[J].Int J Impot Res , 1994, 6: 109-113. Hetian Erpo, Jiang Wenhui, Ling Zhengbao, et al. Observation on the long-term curative effect of penile dorsal nerve microblocking on primary premature ejaculation [J]. Modern Diagnosis and Treatment, 2015, 26(19 ):4449-4450.)
[0004] Based on the above theoretical basis and the possible adverse consequences of surgery, new research is still needed

Method used

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  • Repair and desensitization injection and preparation method thereof
  • Repair and desensitization injection and preparation method thereof
  • Repair and desensitization injection and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] This embodiment provides a preparation method for repairing and reducing sensitivity injection, comprising the following steps:

[0037] (1) Divide 1000 g of water for injection with a pH of 5.0 and a microbial content of 5 cfu / 100 ml or less into two parts to obtain 800 g of the first water for injection and 200 g of the second water for injection;

[0038] (2) Add 1.5 g of lecithin for injection and 2.5 g of glycerin for injection into the first water for injection, stir evenly and heat to 80° C. to obtain a mixture a;

[0039] (3) Add 7.5g of methylene blue, 0.3g of paeonol, and 2.5g of phenoxyethanol to the mixed solution a, stir well, add 200g of the second water for injection, and heat to 98°C to obtain the mixed solution b;

[0040] (4) Cool the mixed solution b to 60°C, filter it with 5 μm, 1 μm, and 0.45 μm microporous membranes in sequence, then continue to cool down to 40°C, sterilize and fill in sequence to obtain the repairing hyposensitizing injection.

Embodiment 2

[0042] This embodiment provides a preparation method for repairing and reducing sensitivity injection, comprising the following steps:

[0043] (1) Divide 980 g of water for injection with a pH of 7.0 and a microbial content of 4 cfu / 100 ml or less into two parts to obtain 882 g of the first water for injection and 98 g of the second water for injection;

[0044] (2) Add 2.5 g of lecithin for injection and 3.5 g of glycerin for injection into the first water for injection, stir evenly and heat to 90° C. to obtain mixed liquid a;

[0045] (3) Add 8.5 g of methylene blue, 0.4 g of paeonol, and 3.5 g of phenoxyethanol to the mixed solution a, stir well, add 98 g of the second water for injection, and heat to 100° C. to obtain the mixed solution b;

[0046] (4) Cool the mixed solution b to 65°C, filter it with 5 μm, 1 μm, and 0.45 μm microporous membranes in sequence, then continue to cool down to 55°C, sterilize and fill in sequence to obtain the repairing Jiangshen injection.

Embodiment 3

[0048] This embodiment provides a preparation method for repairing and reducing sensitivity injection, comprising the following steps:

[0049] (1) being 6.0 with pH, ​​983.65g water for injection with microbial content less than or equal to 3cfu / 100ml is divided into two parts by weight ratio of 9:1 to obtain the first water for injection (90wt.%) and the second water for injection (10wt. %);

[0050] (2) Add 2 g of lecithin for injection and 3 g of glycerin for injection into the first water for injection, stir evenly and heat to 85° C. to obtain mixed solution a;

[0051] (3) Add 8 g of methylene blue, 0.35 g of paeonol, and 3 g of phenoxyethanol to the mixed solution a, stir well, add the second water for injection, and heat to 99° C. to obtain the mixed solution b;

[0052] (4) Cool down the mixture b to 62°C, filter it with 5 μm, 1 μm, and 0.45 μm microporous membranes in sequence, then continue to cool down to 47°C, sterilize and fill in sequence to obtain the repairin...

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Abstract

The invention relates to a repair and desensitization injection and a preparation method thereof. The repair and desensitization injection is prepared from the following raw materials in parts by weight: 98-100 parts of water for injection, 0.15-0.25 part of lecithin for injection, 0.25-0.35 part of glycerol for injection, 0.75-0.85 part of methylene blue, 0.03-0.04 part of paeonol and 0.25-0.35 part of phenoxyethanol. The repair and desensitization injection mainly reduces and delays pleasant sensation of a frenum, a urethra and a glans penis at the same time, and also can play a good repairing role on chronic trauma caused by frequent and excessive stretching of a penis. The preparation method is simple and easy to control, and facilitates large-scale production.

Description

technical field [0001] The invention belongs to the field of medicines, and in particular relates to a repairing hyposensitivity injection and a preparation method thereof. Background technique [0002] Premature ejaculation (PE) is one of the most important problems in men's health. According to statistics, 20-40% of adult men worldwide suffer from different degrees of PE. Because the disease involves personal privacy, many patients avoid medical treatment. The true incidence may be higher. The pathogenesis of PE has not yet been fully elucidated, and its occurrence may be related to psychological factors and sexual organ factors. At present, the clinical treatment is mostly oral serotonin reuptake inhibitors, adrenergic α receptor antagonists, and phosphodiesterase type 5. Drugs or traditional Chinese medicines are the main ones, but most of them have obvious side effects, are relatively expensive, and have poor curative effects. [0003] Local nerve block for patients w...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61K31/728A61K31/5415A61K31/12A61P15/00
CPCA61K9/08A61K9/0019A61K9/0034A61K9/0009A61K31/728A61K31/5415A61K31/12A61P15/00A61K2300/00A61K31/047A61K31/685A61P25/02
Inventor 梅军
Owner 河南省九转九天生物科技有限公司
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