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Application of spathulenol to preparation of anti-migraine drug

A technology of spartanol and migraine, which is applied in the field of preparation of anti-migraine drugs, can solve the problems of poor therapeutic effect of migraine, and achieve good anti-migraine activity, easy to implement, and good therapeutic effects

Inactive Publication Date: 2021-06-04
YUNNAN MINZU UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The technical problem to be solved in the present invention is to solve the problem that the compounds in the prior art have poor therapeutic effect on migraine

Method used

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  • Application of spathulenol to preparation of anti-migraine drug
  • Application of spathulenol to preparation of anti-migraine drug
  • Application of spathulenol to preparation of anti-migraine drug

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Experimental program
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Effect test

preparation example Construction

[0041] The present invention also provides a preparation method of spartanol, which comprises preparing the compound from plants of the genus Scherichia spp. (such as Scherichia spp. Preferably, sparol is prepared from the roots, stems, leaves and fruits of Scherichia cheiferii or Scherichia chinensis. The method has the following steps:

[0042] (1) Scherichia hemanthus and Scherichia hemanthifolia are respectively dried and pulverized, then extracted with a solvent, and the extracts are combined;

[0043] (2) concentrating under reduced pressure the extract in (1) respectively to obtain medicinal extract;

[0044] (3) Suspend the medicinal extract in (2) in water respectively, extract successively with sherwood oil, ethyl acetate and n-butanol, then evaporate the solvent with a rotary evaporator to obtain sherwood oil, ethyl acetate and n-butanol respectively. Butanol extract;

[0045] (4) The petroleum ether extract in (3) was separated by silica gel column chromatograph...

Embodiment 1

[0057] Example 1: Test of Anti-migraine Activity of Scherichia Scherichia Scherichia and Scherichia Scherichia Chai Extracts

[0058] Source of material: Schefflera arboricola Hayata and S. venulosa (Schefflera arboricola Hayata and S. venulosa (Wight et Arn .) Harms). The specimens are preserved in the Herbarium of the School of Medicine for Nationalities, Yunnan University for Nationalities.

[0059] Preparation of the extracts of Scherichia Scherichia Scherichia and Scherichia Scherichia Scherichia: respectively crushing the roots of the dried Scherichia Scherichia Scherichia and Scherichia Scherichia Scherichia to obtain the root fragments of Scherichia Scherichia Scherichia and Scherichia Scherichia Scherichia; The fragments of Scherichia spp. were extracted with 95% ethanol / water reflux for 3 times, each time for 2 hours to obtain the extract; the extracts of Scherichia spp. spare.

[0060] A rat model of migraine induced by nitroglycerin (see scientific literature: Z...

Embodiment 2

[0065] Embodiment 2: further test with Lithuania chinensis

[0066]Example 1 was repeated using 95% methanol / water, 70% ethanol / water and 80% acetone / water as extraction solvents respectively. Experimental results show that with 95% methanol / water, 70% ethanol / water and 80% acetone / water as extraction solvents, the 95% methanol extract, 70% ethanol extract and 80 The extract of % acetone / water also has significant anti-migraine effect on rats, so the anti-migraine activity in Scherichia chinensis can also be obtained with different concentrations of ethanol / water, methanol / water or acetone / water as extraction solvent Element. The results are shown in Table 2.

[0067] Table 2 Effects of different solvent extracts of Scherichia chinensis on the number of head-scratching rats with migraine

[0068]

[0069] n=10

[0070] Note: # Compared with the blank control group, P## Compared with the blank control group, P* Compared with the negative control group, P** Compared with...

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Abstract

The invention relates to application of spathulenol to preparation of an anti-migraine drug. The spathulenol according to the invention can be a natural organic compound or a synthetic organic compound, has relatively high anti-migraine activity, and as an active ingredient, the spathulenol is prepared into an anti-migraine drug or a pharmaceutical composition together with a pharmaceutically acceptable carrier or excipients.

Description

technical field [0001] The present invention relates to the use of spartanol in the preparation of anti-migraine drugs, in particular to the use of spartanol isolated from Araliaceae Scherichia spp. Use in headache medicine. Background technique [0002] Migraine is the most common type of headache clinically. Generally, there is no organic lesion. The main clinical manifestation is paroxysmal moderate to severe, throbbing headache, with pain on one or both sides of the head. Migraine is often related to genetics, and people with poor physical fitness, who do not like sports and engage in mental work are more likely to suffer from migraine. Migraine mainly includes three categories: typical migraine, common migraine and cluster migraine. Typical migraine patients are mostly periodic attacks, and women are more common. Before the onset, most patients may experience blurred vision, flashes of light, hallucinations, blind spots, eye swelling, and emotional instability. Almos...

Claims

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Application Information

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IPC IPC(8): A61K31/045A61P25/06A61P43/00A61K36/25
CPCA61K31/045A61P25/06A61P43/00A61K36/25A61K2236/333
Inventor 黄相中于海波田凯白溪山李艳红蒋孟圆李育晓李红锐
Owner YUNNAN MINZU UNIV
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