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Traditional Chinese medicine porous core-shell type composite particle powder as well as preparation method and application thereof

A technology of composite particles and porous cores, applied in the field of medicine, can solve the problems of poor compressibility, poor direct compression performance, and failure to meet direct compression conditions, etc., and achieve the effect of fast disintegration and improved compressibility

Inactive Publication Date: 2021-07-09
JIANGXI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Preliminary studies have shown that the key direct compression properties of traditional Chinese medicine powders are generally poor, and about 81.5% of traditional Chinese medicine powders have problems of poor fluidity and poor compressibility at the same time, which cannot meet the direct pressure conditions

Method used

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  • Traditional Chinese medicine porous core-shell type composite particle powder as well as preparation method and application thereof
  • Traditional Chinese medicine porous core-shell type composite particle powder as well as preparation method and application thereof
  • Traditional Chinese medicine porous core-shell type composite particle powder as well as preparation method and application thereof

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preparation example Construction

[0033] In the first aspect, the present invention provides a method for preparing Chinese medicine porous core-shell composite particle powder, comprising the following steps:

[0034] (1) Extract the traditional Chinese medicine with a solvent, then filter and concentrate to obtain the concentrated Chinese medicine extract;

[0035] (2) Mix the concentrated Chinese medicine extract, the shell material and the porogen, stir and dissolve until uniform, and prepare the mixture;

[0036] (3) Spray-dry the obtained mixture to obtain porous core-shell composite particle powder of traditional Chinese medicine.

[0037] In one embodiment, the extraction method in the step (1) is selected from any one of the immersion method, decoction method, ultrasonic extraction method, microwave extraction method, percolation method, reflux extraction method, and steam distillation method or multiple combinations.

[0038] Further, the step (1) specifically includes: placing the traditional Chin...

Embodiment 1

[0052] A method for preparing porous core-shell composite particles of traditional Chinese medicine in this embodiment comprises the following steps:

[0053] (1) According to the ratio of Chinese herbal medicines in the commercially available Xiaoer Xishi Tablets, weigh Liushenqu (stir-fried), Citrus aurantii (stir-fried), Atractylodes macrocephala (stir-fried), hawthorn, rice sprouts (stir-fried), malt (stir-fried), and mix After uniformity, place the obtained mixed medicinal materials in an extraction tank, add 10 times the amount of water, soak for 30 min, heat to boiling, keep boiling for 2 hours, filter to get the filtrate; add 8 times the amount of water, heat to boiling, Keep the boiling state for 2 h, filter to take the filtrate; combine the filtrates, concentrate to a density of 1.01 mg / mL, and obtain a concentrated Chinese medicine extract;

[0054] (2) Weigh the following raw materials by weight percentage: polyvinylpyrrolidone (PVP-K30) 7%, ammonium bicarbonate 7%...

Embodiment 2

[0057] A method for preparing porous core-shell composite particles of traditional Chinese medicine in this embodiment comprises the following steps:

[0058] (1) According to the ratio of Chinese herbal medicines in the commercially available Xiaoer Xishi Tablets, weigh Liushenqu (stir-fried), Citrus aurantii (stir-fried), Atractylodes macrocephala (stir-fried), hawthorn, rice sprouts (stir-fried), malt (stir-fried), and mix After uniformity, place the obtained mixed medicinal materials in an extraction tank, add 10 times the amount of water, soak for 30 min, heat to boiling, keep boiling for 2 hours, filter to get the filtrate; add 8 times the amount of water, heat to boiling, Keep the boiling state for 2 h, filter to take the filtrate; combine the filtrates, concentrate to a density of 1.01 mg / mL, and obtain a concentrated Chinese medicine extract;

[0059] (2) Weigh the following raw materials by weight percentage: 7% hydroxypropyl methylcellulose (HPMC E3), 7% ammonium bi...

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Abstract

The invention discloses traditional Chinese medicine porous core-shell type composite particle powder as well as a preparation method and application thereof. The preparation method comprises the following steps: extracting traditional Chinese medicines by adopting a solvent, then filtering and concentrating to obtain a traditional Chinese medicine extraction concentrated solution, mixing the traditional Chinese medicine extraction concentrated solution, a shell layer material and a pore-foaming agent, stirring and dissolving the mixture to be uniform, and performing spray drying on the obtained mixture to obtain the traditional Chinese medicine porous core-shell type composite particle powder. The traditional Chinese medicine porous core-shell type composite particle powder prepared by the process provided by the invention has a remarkable porous structure, is spherical or sphere-like, and has a smooth surface; besides, the co-spray drying process adopted by the invention can be used for directly preparing the porous core-shell type particle powder in the spray drying stage of the traditional Chinese medicine extraction concentrated solution, so that the method is beneficial to process amplification for actual production, and is suitable for continuous production; moreover, after the traditional Chinese medicine porous core-shell type composite particle powder provided by the invention and a pharmaceutically acceptable carrier are prepared into tablets through direct pressing, the obtained tablets disintegrate faster.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a traditional Chinese medicine porous core-shell type composite particle powder and a preparation method and application thereof. Background technique [0002] Tablets are the preferred dosage form for oral medications. Currently, there are three main methods of tablet production: dry granulation, wet granulation, and powder direct compression (direct compression). At present, enterprises usually choose the tableting process after granulation, but the production process is complicated, and the time and economic costs are relatively high; while the powder direct compression process is directly compressed into tablets without granulation, which can simplify the production process and reduce time and economic costs. The cost is reduced, the adverse effects of heat and humidity are eliminated, and the produced tablets are more stable, which can bring considerable economic benefits....

Claims

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Application Information

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IPC IPC(8): A61K9/14A61K47/32A61K47/04A61K47/08A61K47/10A61K47/02A61K47/38A61K47/36A61K47/12A61K9/20A61K36/00A61K36/8998A61P1/14
CPCA61K9/143A61K9/145A61K9/146A61K9/2095A61K36/00A61K36/284A61K36/734A61K36/752A61K36/899A61K36/8998A61P1/14A61K2300/00
Inventor 李哲明良山朱卫丰朱琳陈富财吴文婷毛志旋
Owner JIANGXI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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