Nrf2 activator and application thereof in preparation of medicines/health food/dietary supplements

A technology for dietary supplements and health food, which is applied in the functions of food ingredients, plant/algae/fungus/moss ingredients, application and other directions, can solve the problems of side effects, poor effect, slow onset of effect, etc., and achieves high safety, The effect of preventing and treating diabetic nephropathy and alleviating metabolic disorders

Pending Publication Date: 2021-07-09
CHONGQING UNIV OF EDUCATION
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Most of the diabetic nephropathy drugs currently on the market are drugs for controlling blood sugar, anticoagulation, controlling blood pressure, and reducing urinary protein. no significant effect

Method used

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  • Nrf2 activator and application thereof in preparation of medicines/health food/dietary supplements
  • Nrf2 activator and application thereof in preparation of medicines/health food/dietary supplements
  • Nrf2 activator and application thereof in preparation of medicines/health food/dietary supplements

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0054] The preparation of embodiment 1 Chinese medicine extract

[0055] Chinese herbal extract 1

[0056] Weigh 50g of astragalus root, 20g of Codonopsis pilosula, 10g of salvia miltiorrhiza and 20g of Chinese yam, 100g in total, add 1000g of water after mixing, soak for 30 minutes, then decoct for 2 hours, and filter to obtain the filtrate; add 800g of water to the filter residue, decoct for 2 hours, filter A filtrate was obtained. After combining the two filtrates, concentrate under reduced pressure for 1.5 hours at a pressure of 0.05 MPa and a temperature of 50° C., and spray-dry the concentrated solution to obtain a dry powder of Chinese medicine extract 1.

[0057] Chinese herbal extract 2

[0058] Weigh 40g of astragalus root, 20g of Codonopsis pilosula, 20g of salvia miltiorrhiza and 20g of yam, 100g in total, add 1500g of water after mixing, soak for 30 minutes, then decoct for 2 hours, filter to obtain the filtrate; add water to the filter residue 1000g, decoct for...

Embodiment 2

[0059] The preparation of embodiment 2 compositions

[0060] Composition 1

[0061] Weigh 15 g of compound I (betatin) in which R is H and 15 g of dry powder of traditional Chinese medicine extract 1, and mix them uniformly to obtain composition 1.

[0062] Composition 2

[0063] Weigh and weigh 20 g of compound I (betatin) in which R is H and 10 g of dry powder of traditional Chinese medicine extract 2, and mix them uniformly to obtain composition 2.

Embodiment 3

[0065] The db / db mice were randomly divided into 6 groups according to Table 1:

[0066] Table 1 Grouping of db / db mouse models

[0067] model group experimental method Diabetic nephropathy model group (Ctrl) Standard Feed Feeding Extract 1 group (TQW1) 5g / kg Ratio Mix Extract 1 with feed and feed Extract Group 2 (TQW2) 5g / kg ratio Mix the extract 2 with the feed and feed Betalain group (BCN) 1g / kg ratio of betalain mixed with feed and fed Composition 1 group (ZHW1) 1.5g / kg ratio mixes composition 1 with feed and feeds Composition 2 group (ZHW2) 1.5g / kg ratio mixes composition 2 with feed and feeds

[0068] According to the grouping and method in Table 1, feeding continued for 8 weeks. Collect blood samples to detect total cholesterol (TC), total triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), very low-density lipoprotein cholesterol (VLDL -C), the levels o...

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PUM

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Abstract

The invention belongs to the technical field of preparation of medicines and health foods, and relates to an Nrf2 activator and application thereof in preparation of medicines/health food/dietary supplements. The Nrf2 activator comprises a compound I and a traditional Chinese medicine extract; the mass ratio of the compound I to the traditional Chinese medicine extract is (1-10): (0.5-5); the traditional Chinese medicine extract is one or more of an astragalus extract, a codonopsis pilosula extract, a salvia miltiorrhiza extract and a Chinese yam extract. The Nrf2 activator and a pharmaceutically acceptable carrier or excipient are used for preparing medicines/health food/dietary supplements for preventing or treating diabetic nephropathy. The Nrf2 activator can activate an Nrf2 signal channel in a targeted mode, remarkably inhibit the accumulation and oxidative stress of collagen and prevent and treat diabetic nephropathy.

Description

technical field [0001] The invention belongs to the technical field of medicine and health food preparation, and in particular relates to an Nrf2 activator and its application in the preparation of medicine / health food / dietary supplement. Background technique [0002] Diabetic nephropathy is one of the most important complications of diabetic patients, and its incidence is on the rise in my country. Diabetic nephropathy has a prevalence of 10-40% in adults with type 2 diabetes and is the leading cause of death in patients with type 1 or type 2 diabetes worldwide. Due to its complex metabolic disorders, once it develops into end-stage renal disease, it is often more difficult to treat than other kidney diseases. Therefore, timely prevention and treatment is of great significance for delaying diabetic nephropathy. An increasing number of studies have shown that diabetic nephropathy is characterized by basement membrane thickening, tubular and glomerular hypertrophy, and accum...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8945A61K31/4439A61K31/706A61P3/10A61P13/12A21D2/36A21D13/06A23G3/36A23G3/48A23L2/39A23L2/52A23L21/10A23L33/10A23L33/105
CPCA61K31/4439A61K31/706A61K36/481A61K36/344A61K36/537A61K36/8945A61P3/10A61P13/12A23L33/10A23L33/105A23G3/48A23G3/364A21D2/366A21D13/06A23L2/52A23L2/39A23L21/10A61K2236/331A61K2236/39A61K2236/53A61K2236/51A23V2002/00A61K2300/00A23V2200/328A23V2200/30A23V2300/14A23V2300/10A23V2300/50
Inventor 谭君徐敏轩葛晨旭代先玲况琴钟绍宇
Owner CHONGQING UNIV OF EDUCATION
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