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Application of bone protecting capsule as medicine for treating traumatic fracture

A traumatic, capsule technology, applied in the field of traditional Chinese medicine, can solve problems such as no related research on drugs, and achieve the effects of improving overall efficiency, accelerating generation, and promoting bone formation.

Pending Publication Date: 2021-07-16
广东安诺药业股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Whether the traditional Chinese medicine Hugu Capsule can be used as a traumatic fracture drug has not yet been studied

Method used

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  • Application of bone protecting capsule as medicine for treating traumatic fracture
  • Application of bone protecting capsule as medicine for treating traumatic fracture
  • Application of bone protecting capsule as medicine for treating traumatic fracture

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Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0020] The present invention will be further described below in conjunction with specific experiments.

[0021] 1 Experimental materials

[0022] 1.1 Experimental animals

[0023] SPF-grade male and female SD rats, 3 months old, were purchased from the Guangdong Provincial Medical Experimental Animal Center, license number: SCXK (Guangdong) 2013-0002, and the experiments were carried out at the Experimental Animal Center of Guangdong Pharmaceutical University.

[0024] 1.2 Drugs and preparation methods

[0025] Hugu Capsules (Guoyao Zhunzi: Z20040124, production batch number: 20170207, specifications: 0.45g / capsule), provided by Guangdong Annuo Pharmaceutical Co., Ltd.; according to the conversion of human equivalent doses, the Hugu Capsules were formulated to a concentration of 0.12 g / ml solution.

[0026] 1.3 Main reagents and instruments

[0027] Calcein (Sigma, batch number SLBRO830V), toluidine blue (Sigma, batch number 92-31-9); Leica RM2500 slicer, Leica SP1600 saw ...

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Abstract

The invention provides application of a bone protecting capsule as medicine for treating traumatic fracture, and relates to the technical field of traditional Chinese medicine application. The bone protecting capsule with a traditional Chinese medicine formula comprising fleeceflower roots, herba epimedii, prepared rehmannia roots, tortoise shells, radix morindae officinalis, eucommia barks, radix dipsaci, rhizoma drynariae, radix angelicae sinensis and Chinese yam is used as medicine for treating traumatic fracture. By constructing a rat fracture model, the effects of the bone protecting capsule for promoting bone formation, accelerating generation of bony callus of a fracture part and improving the total efficiency of fracture healing are fully verified, and an experimental basis is provided for treatment of traumatic fracture by using the bone protecting capsule.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine application, in particular to the application of Gugu Capsule as a medicine for treating traumatic fractures. Background technique [0002] Fractures disrupt the continuity and integrity of the bone. Solving the sluggishness of fracture healing is the problem that the present invention focuses on solving. Western medicine mostly adopts surgical bone grafting, anti-inflammatory and bone-promoting western medicine treatment, but western medicine has large side effects and expensive operation costs. Traditional Chinese medicine improves the quality of the callus and accelerates healing by improving the blood supply to the fracture site. [0003] Traditional Chinese medicine has a long history of understanding and treating fractures, and has advantages that Western medicine and Western medicine cannot match. When Western medicine treats severe fractures, surgical fixation is oft...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8945A61P19/08A61K9/48A61D1/00A61K35/586
CPCA61D1/00A61K9/48A61K35/586A61K36/126A61K36/185A61K36/232A61K36/296A61K36/46A61K36/704A61K36/746A61K36/804A61K36/8945A61P19/08A61K2300/00
Inventor 潘翠萍陈锐东李青南
Owner 广东安诺药业股份有限公司
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