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Erythrocyte recognition and posture estimation method based on microfluidic lensless imaging

A posture estimation and red blood cell technology, which is applied in the field of medical diagnosis and image analysis, can solve the problems of high price, high professional knowledge requirements of operators, and large detection equipment, and achieve high real-time performance, undetermined posture, and simple operation. Effect

Active Publication Date: 2021-07-27
XIAN UNIV OF TECH
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Problems solved by technology

However, the detection equipment of these two methods has the problems of large size, high price, and high requirements for the professional knowledge of operators.

Method used

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  • Erythrocyte recognition and posture estimation method based on microfluidic lensless imaging
  • Erythrocyte recognition and posture estimation method based on microfluidic lensless imaging
  • Erythrocyte recognition and posture estimation method based on microfluidic lensless imaging

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Embodiment Construction

[0055] The present invention will be described in detail below with reference to the accompanying drawings and specific embodiments.

[0056] The invention provides a method for erythrocyte identification and attitude estimation based on microfluidic lensless imaging, which utilizes a microfluidic chip and a lensless imaging system to collect diffraction images of erythrocytes to identify and estimate erythrocytes in microfluidics. Lensless imaging systems such as figure 1 As shown, it includes a shading plate 12, a monochromatic light source 15, a convex lens 11, a microfluidic chip 13 and a CMOS image sensor 14. The light of the monochromatic light source 15 passes through the micro-hole 10 and is refracted by the convex lens 11 to form parallel rays of light, which are irradiated on the micro- On the fluidic chip 13, a biological cell sample containing red blood cells is passed through the microfluidic chip 13, and is placed on the CMOS image sensor 14, and the CMOS image s...

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Abstract

The invention discloses an erythrocyte recognition and posture estimation method based on micro-fluidic lens-free imaging. The method specifically comprises the following steps: preparing a biological cell sample containing erythrocytes; introducing a biological cell sample into a micro-fluidic chip, and placing the micro-fluidic chip on a CMOS (Complementary Metal-Oxide-Semiconductor Transistor) image sensor of a lens-free imaging system; turning on a monochromatic light source to irradiate the micro-fluidic chip; acquiring diffraction images of the red blood cells; establishing a Fresnel straight-edge diffraction model; establishing an arc edge diffraction model; establishing a red blood cell recognition and posture estimation model; and collecting a diffraction pattern of the red blood cells, recognizing the red blood cells through the red blood cell recognition and posture estimation model, and estimating the posture of the red blood cells in microfluidics. According to the invention, red blood cell identification and posture estimation are realized by using the diffraction image information of red blood cells.

Description

technical field [0001] The invention belongs to the technical field of medical diagnosis and image analysis, and relates to a red blood cell identification and attitude estimation method based on microfluidic lensless imaging. Background technique [0002] Red blood cell (RBC) size is an important parameter for medical diagnosis. A complete blood count (CBC) is one of the common blood tests prescribed by doctors for clinical diagnosis and prognosis. As the most basic blood test, a complete blood count (CBC) is used to assess overall health and detect a wide range of diseases, including anemia, infections and leukemia. Today's blood cell count is no longer a simple red blood cell, white blood cell and platelet count function, but a comprehensive test of blood cells. In the International Council for Standardization of Hematology (ICSH) 2014 Guidelines for the Evaluation of Hematology Analyzers, parameters related to red blood cell size, such as red blood cell distribution wi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N21/47
CPCG01N21/4788
Inventor 李建伟吴银峰余宁梅戴力
Owner XIAN UNIV OF TECH
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