Application of angelica sinensis-astragalus membranaceus blood-activating preparation in preparation of medicine for preventing or treating diabetic complications

A technology for diabetes and complications, which is applied in the application field of Guiqi Huoxue preparation in the prevention or treatment of diabetes complications, and can solve the problems of limited clinical application, high price of some chemical drugs, and unsatisfactory curative effect.

Pending Publication Date: 2021-07-30
LUNAN PHARMA GROUP CORPORATION
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The above-mentioned chemical drug interventions and treatment measures can all play a certain therapeutic effect on the different pathogenesis of DPN,

Method used

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  • Application of angelica sinensis-astragalus membranaceus blood-activating preparation in preparation of medicine for preventing or treating diabetic complications
  • Application of angelica sinensis-astragalus membranaceus blood-activating preparation in preparation of medicine for preventing or treating diabetic complications
  • Application of angelica sinensis-astragalus membranaceus blood-activating preparation in preparation of medicine for preventing or treating diabetic complications

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0087] The preparation of embodiment 1 Guiqi Huoxue Capsule

[0088]

[0089] A. Weigh thirteen medicinal materials including Astragalus, Angelica, Radix Paeoniae Alba, Radix Polygoni Multiflori, Lycium Barbarum, Mistletoe, Antler, Rhizoma Drynaria, Clematis, Speranthum, Musk, Pueraria Radix, and Ligusticum Chuanxiong, among which Radix Polygoni Multiflori and Lycium barbarum are prepared Net selection, astragalus, angelica, chuanxiong, kudzu root, white peony root and rhizoma drynariae, and slices; mistletoe, clematis, and Speranthemus, and cut into sections; deer antler, musk, and grinding into fine powder, set aside ;

[0090] B. Mistletoe, kudzu root, and Chuanxiong are extracted twice with 60% ethanol, each time for 1.5 hours, the extracts are combined, filtered, the filtrate recovers ethanol, and concentrated under reduced pressure to a relative density of 1.18 at 50 ° C ~ 60 ° C Extract, get extract I, for subsequent use;

[0091] C. Astragalus, Angelica, Paeoniae ...

Embodiment 2

[0093] The preparation of embodiment 2 Guiqi Huoxue Granules

[0094]

[0095]

[0096] A. Weigh thirteen medicinal materials including Astragalus, Angelica, Radix Paeoniae Alba, Radix Polygoni Multiflori, Lycium Barbarum, Mistletoe, Antler, Rhizoma Drynaria, Clematis, Speranthum, Musk, Pueraria Radix, and Ligusticum Chuanxiong, among which Radix Polygoni Multiflori and Lycium barbarum are prepared Net selection, astragalus, angelica, chuanxiong, kudzu root, white peony root and rhizoma drynariae, and slices; mistletoe, clematis, and Speranthemus, and cut into sections; deer antler, musk, and grinding into fine powder, set aside ;

[0097] B. Mistletoe, kudzu root and Chuanxiong are extracted twice with 55% ethanol, 1.5 hours each time, the extracts are combined, filtered, ethanol is recovered from the filtrate, concentrated under reduced pressure to a relative density of 1.19 at 50°C to 60°C Extract, get extract I, for subsequent use;

[0098] C. Astragalus, Angelica,...

Embodiment 3

[0100] The preparation of embodiment 3 Guiqi Huoxue Tablets

[0101]

[0102] A. Weigh thirteen medicinal materials including Astragalus, Angelica, Radix Paeoniae Alba, Radix Polygoni Multiflori, Lycium Barbarum, Mistletoe, Antler, Rhizoma Drynaria, Clematis, Speranthum, Musk, Pueraria Radix, and Ligusticum Chuanxiong, among which Radix Polygoni Multiflori and Lycium barbarum are prepared Net selection, astragalus, angelica, chuanxiong, kudzu root, white peony root and rhizoma drynariae, and slices; mistletoe, clematis, and Speranthemus, and cut into sections; deer antler, musk, and grinding into fine powder, set aside ;

[0103] B. Mistletoe, kudzu root, Chuanxiong 3 flavors plus 61% ethanol extraction twice, each extraction 1.5 hours, combined extracts, filtered, the filtrate recovered ethanol, concentrated under reduced pressure to a relative density of 1.21 at 50 ℃ ~ 60 ℃ Extract, get extract I, for subsequent use;

[0104] C. Astragalus, Angelica, Radix Paeoniae Alba...

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Abstract

The invention belongs to the field of traditional Chinese medicines, and particularly discloses application of an angelica sinensis-astragalus membranaceus blood-activating preparation in preparation of a medicine for preventing or treating diabetic complications. The angelica sinensis-astragalus membranaceus blood-activating preparation is prepared from thirteen raw medicinal materials including astragalus membranaceus, angelica sinensis, radix paeoniae alba, radix polygoni multiflori preparata, fructus lycii, mistletoe, cornu cervi pantotrichum, rhizoma drynariae, radix clematidis, garden balsam stem, musk, radix puerariae and ligusticum wallichii, and has the effects of tonifying qi and kidney and promoting blood circulation to remove meridian obstruction. Pharmacodynamic tests show that the angelica sinensis-astragalus membranaceus blood activating preparation can effectively accelerate the ischial nerve conduction speed of diabetic peripheral neuropathy model rats, remarkably reduce the serum MDA level of the rats, improve the activity level of SOD and GSH-Px, improve the free radical scavenging capacity of the organisms and enhance the oxidation resistance of the organisms and tissues, so that the rat ischial nerve injury is protected and repaired, the traditional Chinese medicine composition has an exact treatment effect on diabetic peripheral neuropathy, is comprehensive in effect and low in toxic and side effects, and has a wide market prospect.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine and relates to a new application of a Guiqi Huoxue preparation, in particular to an application of a Guiqi Huoxue preparation in preventing or treating diabetic complications. Background technique [0002] Diabetes is a common chronic metabolic disease and one of the most prevalent diseases in the world. With the rapid development of social economy, the change of people's lifestyle and population aging, the incidence of diabetes is increasing year by year. The complications of diabetes are also gradually increasing, and there are more than 100 complications of diabetes, which is the disease with the most known complications. More than half of diabetes deaths are caused by cardiovascular and cerebrovascular diseases, and 10% are caused by peripheral neuropathy. Amputation due to diabetes is 10 to 20 times that of non-diabetics. Clinical data show that about 10 years after the onset of...

Claims

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Application Information

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IPC IPC(8): A61K36/815A61K9/48A61P3/10A61P25/02A61K35/32A61K35/55
CPCA61K9/0053A61K9/48A61K35/32A61K35/55A61K36/126A61K36/185A61K36/232A61K36/236A61K36/47A61K36/481A61K36/488A61K36/65A61K36/704A61K36/71A61K36/716A61K36/815A61P3/10A61P25/02A61K2300/00
Inventor 张贵民冯倩庄华青
Owner LUNAN PHARMA GROUP CORPORATION
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