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Application of comt protein in prediction of good response to superovulation in cynomolgus monkeys

A technology of superovulation and cynomolgus monkeys, which is applied in the field of superovulation and can solve problems such as unsatisfactory superovulation effects

Active Publication Date: 2022-04-26
SOUTH CHINA AGRI UNIV
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  • Description
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Problems solved by technology

In addition, menstrual cycle disorder, diarrhea, and unregressed corpus luteum on the ovary can also lead to unsatisfactory effects of superovulation

Method used

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  • Application of comt protein in prediction of good response to superovulation in cynomolgus monkeys
  • Application of comt protein in prediction of good response to superovulation in cynomolgus monkeys

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Embodiment Construction

[0023] Specific embodiments of the present invention will be further described below. It should be noted here that the descriptions of these embodiments are used to help understand the present invention, but are not intended to limit the present invention. In addition, the technical features involved in the various embodiments of the present invention described below may be combined with each other as long as they do not constitute a conflict with each other.

[0024] The test methods used in the following experimental examples are conventional methods unless otherwise specified; the materials and reagents used are commercially available reagents and materials unless otherwise specified.

[0025] 1. Superovulation experiment process

[0026]Observe the physiological state of adult female cynomolgus monkeys in the target monkey group every day, and register the cage number and monkey number on the first day when menstruation occurs. On the 1st to 4th days of menstruation, ven...

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Abstract

The invention relates to the application of COMT protein in the prediction of good response to superovulation in cynomolgus monkeys, belonging to the technical field of superovulation. The method of proteomics is used to analyze the first day of the successful superovulation group and the fifth day of the successful superovulation group. , Superovulation failure group on day 1 and superovulation failure group on day 5 for bioinformatics analysis to obtain the differential protein among the groups. From the study of protein level, the changes of protein expression revealed in the blood of superovulated monkeys were explored. In superovulation in cynomolgus monkeys, COMT protein was not detected in the superovulation failure group, but it still existed on the 5th day in the superovulation success group, which may suggest that the stability of COMT protein expression may be beneficial to superovulation. ovulation. Therefore, COMT protein has become a new molecule to predict a good response to superovulation in cynomolgus monkeys, and has practical application value.

Description

technical field [0001] The invention relates to the technical field of superovulation, and more specifically, relates to the application of COMT protein in predicting good response to superovulation in cynomolgus monkeys. Background technique [0002] Superovulation refers to the use of exogenous hormones to stimulate the ovaries of female animals, to promote the simultaneous growth and development of multiple follicles in the ovary, and finally to obtain multiple mature oocytes. In cynomolgus monkeys, only one dominant follicle matures and ovulates during the natural menstrual cycle. If the superovulation technique is used during the menstrual period, the number of oocytes per ovulation can be increased from 1 to 10-20 or even more. Mature oocytes are important materials for research on human diseases, genetic engineering and embryo engineering. However, the number of qualified oocytes obtained through natural cycle is extremely small, which is far from meeting the experi...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N33/573
CPCG01N33/573G01N2333/91017G01N2800/36
Inventor 杨世华郭韵仪侯润杰
Owner SOUTH CHINA AGRI UNIV
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