Application of RPL26 protein in predicting good response of cynomolgus monkeys to superovulation

1. RPL26, superovulation technology, applied in the field of superovulation, can solve problems such as unclear interaction

Active Publication Date: 2021-09-07
SOUTH CHINA AGRI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the current research on the relationship between RPL26 protein and superovulation has not been reported, mainly focusing on the role of ribosomal protein and mosquito fecundity.
Therefore, the interaction between RPL26 and ovaries, oocytes, etc. during superovulation is not yet clear

Method used

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  • Application of RPL26 protein in predicting good response of cynomolgus monkeys to superovulation
  • Application of RPL26 protein in predicting good response of cynomolgus monkeys to superovulation

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Embodiment Construction

[0023] Specific embodiments of the present invention will be further described below. It should be noted here that the descriptions of these embodiments are used to help understand the present invention, but are not intended to limit the present invention. In addition, the technical features involved in the various embodiments of the present invention described below may be combined with each other as long as they do not constitute a conflict with each other.

[0024] The test methods used in the following experimental examples are conventional methods unless otherwise specified; the materials and reagents used are commercially available reagents and materials unless otherwise specified.

[0025] 1. Superovulation experiment process

[0026]Observe the physiological state of adult female cynomolgus monkeys in the target monkey group every day, and register the cage number and monkey number on the first day when menstruation occurs. On the 1st to 4th days of menstruation, ven...

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Abstract

The invention relates to application of RPL26 protein in predicting good response of cynomolgus monkeys to superovulation, and belongs to the technical field of superovulation. Biological information analysis is carried out on blood sample protein on the first day of a superovulation success group, the fifth day of the superovulation success group, the first day of a superovulation failure group and the fifth day of the superovulation failure group through adopting a proteomics method, and differential proteins among the groups are obtained. The protein expression change of the blood of the superovulation monkeys is discussed from protein level research. In superovulation of cynomolgus monkeys, RPL26 protein exists on the fifth day in a superovulation failure group and is not expressed on the fifth day in a superovulation success group, the fact possibly prompts that ribosome stress occurs in cynomolgus monkeys with poor response in the superovulation process, and accordingly the cell cycle progress is affected, the growth and development of oocytes in the superovulation process are affected, and superovulation is not facilitated. Therefore, the RPL26 protein becomes a new molecule for predicting good response of the cynomolgus monkey to superovulation, and has practical application value.

Description

technical field [0001] The invention relates to the technical field of superovulation, and more specifically, relates to the application of RPL26 protein in predicting good response to superovulation in cynomolgus monkeys. Background technique [0002] Superovulation refers to the use of exogenous hormones to stimulate the ovaries of female animals, to promote the simultaneous growth and development of multiple follicles in the ovary, and finally to obtain multiple mature oocytes. In cynomolgus monkeys, only one dominant follicle matures and ovulates during the natural menstrual cycle. If the superovulation technique is used during the menstrual period, the number of ovulated oocytes can be increased from 1 to 10-20 or even more. Mature oocytes are important materials for research on human diseases, genetic engineering and embryo engineering. However, the number of qualified oocytes obtained through natural cycle is extremely small, which is far from meeting the experiment...

Claims

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Application Information

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IPC IPC(8): G01N33/68
CPCG01N33/68
Inventor 杨世华刘保臻侯润杰
Owner SOUTH CHINA AGRI UNIV
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