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Compound traditional Chinese medicine composition for treating coronary heart disease as well as preparation method and application thereof

A compound traditional Chinese medicine and composition technology, which can be used in drug combinations, cardiovascular system diseases, active ingredients of heterocyclic compounds, etc., can solve the problems of drug resistance, side effects, poor efficacy, etc. Side effects, effects of flexible formulations

Pending Publication Date: 2021-08-24
JIANGSU SUNAN PHARMA IND CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For patients, although medication can be controlled in a short period of time, the long-term curative effect is often not good, and long-term use of these western medicines will not only cause side effects to the body, but also produce drug resistance

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Party:

[0030] 30 parts of Fritillaria, 25 parts of Curcuma, 30 parts of Polygonatum, 20 parts of Chuanxiong, 18 parts of Angelica,

[0031] 20 parts of cinnamon, 15 parts of honeysuckle, 12 parts of Poria, 11 parts of Jiangxiang, 12 parts of Ophiopogon japonicus,

[0032] 5 parts of wild jujube, 5 parts of amomum, 5 parts of licorice, 0.02 part of atorvastatin.

[0033] Preparation:

[0034] (1) Take Zhe Fritillaria, Curcuma, Polygonatum, Chuanxiong, Angelica, Cinnamon, Lonicerae, Poria, Dalbergia, Ophiopogon japonicus, Semen jujube, Amomum and licorice, add 7 times the amount of pure water, and extract twice at 85°C , 3 hours each time, combine the extracts, concentrate to obtain liquid extract;

[0035] (2) Put atorvastatin in pure water, add hypromellose, and stir at 4000rpm for 10min to obtain atorvastatin suspension;

[0036] (3) The above fluid extract and suspension are used in combination to obtain the compound Chinese medicine composition.

Embodiment 2

[0038] Party:

[0039] 28 parts of Fritillaria, 22 parts of Curcuma, 28 parts of Polygonatum, 18 parts of Chuanxiong, 15 parts of Angelica,

[0040] 18 parts of cinnamon, 12 parts of honeysuckle, 11 parts of Poria, 10 parts of Jiangxiang, 10 parts of Ophiopogon japonicus,

[0041] 4 parts of wild jujube, 4 parts of amomum, 4 parts of licorice, 0.02 part of atorvastatin.

[0042] Preparation:

[0043] (1) Take Zhe Fritillaria, Curcuma, Polygonatum, Chuanxiong, Angelica, Cinnamon, Lonicerae, Poria, Dalbergia, Ophiopogon japonicus, Semen jujube, Amomum and licorice, add 7 times the amount of pure water, and extract twice at 85°C , 3 hours each time, combine the extracts, concentrate to obtain liquid extract;

[0044] (2) Put atorvastatin in pure water, add hypromellose, and stir at 4000rpm for 10min to obtain a suspension;

[0045] (3) The above fluid extract and suspension are used in combination to obtain the compound Chinese medicine composition, which are mixed, concentra...

Embodiment 3

[0047] Party:

[0048] 32 parts of Fritillaria, 28 parts of Curcuma, 32 parts of Polygonatum, 22 parts of Chuanxiong, 20 parts of Angelica,

[0049] 22 parts of cinnamon, 18 parts of honeysuckle, 14 parts of Poria, 12 parts of Jiangxiang, 15 parts of Ophiopogon japonicus,

[0050] 6 parts of wild jujube, 6 parts of amomum, 6 parts of licorice, 0.02 part of atorvastatin.

[0051] Preparation:

[0052] (1) Take Zhe Fritillaria, Curcuma, Polygonatum, Chuanxiong, Angelica, Cinnamon, Lonicerae, Poria, Dalbergia, Ophiopogon japonicus, Semen jujube, Amomum and licorice, add 7 times the amount of pure water, and extract twice at 85°C , 3 hours each time, combine the extracts, concentrate to obtain liquid extract;

[0053] (2) Put atorvastatin in pure water, add hypromellose, and stir at 4000rpm for 10min to obtain a suspension;

[0054] (3) The above liquid extract and suspension are used in combination to obtain the compound Chinese medicine composition, which are mixed, concentr...

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Abstract

The invention discloses a compound traditional Chinese medicine composition for treating coronary heart disease as well as a preparation method and application thereof. The compound traditional Chinese medicine composition is mainly prepared from the following raw materials in parts by weight: 25-35 parts of thunberg fritillary bulb, 20-30 parts of radix curcumae, 25-35 parts of rhizoma polygonati, 15-25 parts of ligusticum wallichii, 10-25 parts of angelica sinensis, 15-25 parts of cinnamon, 10-20 parts of honeysuckle stem, 10-15 parts of poria cocos, 8-15 parts of lignum dalbergiae odoriferae, 5-20 parts of radix ophiopogonis, 2-8 parts of wild jujube, 2-8 parts of fructus amomi, 2-8 parts of liquorice and 0.02 part of atorvastatin. According to the compound traditional Chinese medicine composition for treating the coronary heart disease, the mode of combining traditional Chinese medicines and western medicines is adopted, the traditional Chinese medicines are novel and reasonable in compatibility, all the components have a synergistic effect, the medicine effect of the western medicines can be effectively enhanced and compensated, and the problem that existing western medicines are used for a long time or generate medicine resistance can be solved. In addition, the preparation method is simple, low in cost and flexible in preparation form, and can be further popularized and applied.

Description

technical field [0001] The invention belongs to the field of compound traditional Chinese medicine composition, and in particular relates to a compound traditional Chinese medicine composition for treating coronary heart disease and its preparation method and application. Background technique [0002] Coronary heart disease, also known as coronary atherosclerotic heart disease, is a heart disease caused by atherosclerotic lesions in the coronary arteries that cause stenosis or blockage of the vessel lumen, resulting in myocardial ischemia, hypoxia or necrosis. Coronary heart disease mostly occurs in middle-aged and elderly people over 40 years old. These patients mostly have the characteristics of viscera gradually weakening, and Qi, blood, yin and yang are increasingly depleted. "Yellow Emperor's Internal Classic Su Wen" said, "After forty years, the Yin Qi is half." It points out that the aging of the human body is preceded by the loss of Yuan Yin. Once Yuanyin is deficie...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9066A61P9/10A61K31/40
CPCA61K36/8966A61K36/9066A61K36/8969A61K36/236A61K36/232A61K36/54A61K36/355A61K36/076A61K36/48A61K36/8968A61K36/725A61K36/9064A61K36/484A61K31/40A61P9/10A61K2236/331A61K2236/39A61K2236/53A61K2236/51
Inventor 俞洋徐飞何燕刘宏飞王俊
Owner JIANGSU SUNAN PHARMA IND CO LTD
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