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Kit for differential diagnosis of EM/FEM

A kit and reagent technology, applied in the field of kits for the differential diagnosis of ovarian endometriosis/other benign tumors of the ovary, to achieve the effects of good differential specificity, improved accuracy, and good therapeutic effect

Active Publication Date: 2021-08-31
PEKING UNION MEDICAL COLLEGE HOSPITAL CHINESE ACAD OF MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Currently, highly sensitive, specific, and clinically relevant biomarkers for the differential diagnosis of EM remain to be discovered

Method used

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  • Kit for differential diagnosis of EM/FEM
  • Kit for differential diagnosis of EM/FEM
  • Kit for differential diagnosis of EM/FEM

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] Example 1 Screening for protein markers related to EM / OC / FEM

[0041] 1. Experimental materials

[0042] 1. Research sample

[0043] A total of 30 patients with three groups of disease types who were treated in the Obstetrics and Gynecology Department of Peking Union Medical College Hospital from January 2019 to January 2020 were collected and included. The basic information of the patients is shown in Table 1.

[0044] (1) Ovarian endometriosis group (EM group): 10 cases: The included patients did not receive endometriosis-related drug treatment for half a year before operation.

[0045] (2) Ovarian malignant tumor group (OC group): 10 cases: the pathology was consistent with epithelial ovarian cancer.

[0046] (3) Other benign tumors of the ovary (FEM group): 10 cases: Pathologically excluded complicated endometriosis.

[0047] Table 1 Basic information of the patient population screened by protein markers

[0048]

[0049]

[0050] IQR: interquartile range;...

Embodiment 2

[0154] Example 2 Validation of protein markers

[0155] 1. Experimental materials

[0156] 1. Research sample

[0157] From January 2019 to January 2020, serum samples of 203 inpatients in the Department of Obstetrics and Gynecology of Peking Union Medical College Hospital were collected for protein marker verification, including 88 patients in the EM group, 90 patients in the FEM group, and 25 patients in the OC group. For example, the basic information of all included patients is shown in Table 6.

[0158] Sample inclusion criteria:

[0159] Inclusion criteria: a. Adnexal tumors or pelvic masses found by ultrasound results, suspicious EM or OC or unknown significance; b. Surgical treatment confirmed at Peking Union Medical College Hospital.

[0160] Exclusion criteria: a. combined with other gynecological benign and malignant tumors; b. clinically suspected malignant tumors; c. other systemic malignant tumors or a history of malignant tumors; d. pregnancy.

[0161] Table 6...

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Abstract

The invention relates to the technical field of biology, in particular to a reagent for identifying ovarian endometriosis / other ovarian benign tumors and application of the reagent. The invention provides application of a reagent for detecting the content of a biomarker in a subject sample in preparation of a product for differential diagnosis of ovarian endometriosis / other ovarian benign tumors. The biomarkers comprise CA125, SELL, LILRA3, IGKC and / or DSC2 (Differentiated Sequence Cells). The invention also provides a marker CA125, SELL, LILRA3, IGKC and / or DSC2 for differential diagnosis of ovarian endometriosis / other ovarian benign tumors, can be used for preparing a detection kit and the like for differential diagnosis of EM / FEM, and has good identification specificity and high sensitivity. By adopting the kit, the accuracy of clinical EM / FEM differential diagnosis can be improved, so that a patient can obtain more accurate treatment measures, and a better treatment effect is obtained.

Description

technical field [0001] The invention relates to the field of biotechnology, in particular to a kit for differential diagnosis of ovarian endometriosis / other ovarian benign tumors. Background technique [0002] Endometriosis (endometriosis) is a common benign gynecological disorder characterized by the growth of functional endometrial glands and stroma outside the uterine cavity. About one in 10 women of reproductive age suffers from endometriosis. However, it occurs in approximately 50% of women seeking evaluation for infertility and is more prone to disease progression; it occurs in as much as 70% of women in pain. Endometriosis is a benign lesion histomorphologically, but it can exhibit tumor-like features such as invasion, implantation, and distant metastasis in biological behavior. The clinical manifestations of endometriosis are complicated and interfere with the normal life of patients, and severe cases can cause heavy psychological pressure. Early detection plays a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/68C12Q1/6883
CPCG01N33/6893C12Q1/6883G01N2800/364G01N2800/36C12Q2600/158
Inventor 王姝陈倩刘阳钞晓培郎景和
Owner PEKING UNION MEDICAL COLLEGE HOSPITAL CHINESE ACAD OF MEDICAL SCI
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