Application of meflunidone in preparation of medicine for treating acute kidney injury

A technology of acute kidney injury and meflunidone, applied in the field of application of meflunidone in the preparation of drugs for the treatment of acute kidney injury, to achieve the effect of creatinine level protection
CN113456642AActive Publication Date: 2021-10-01CENT SOUTH UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
CENT SOUTH UNIV
Publication Date
2021-10-01

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Abstract

The invention discloses an application of meflunidone in preparation of a medicine for treating acute kidney injury. When meflunidone is applied to ischemia reperfusion induced AKI mice for treatment, renal tubule pathological injuries can be relieved, the renal function can be improved, and the levels of renal function indexes of urea nitrogen and creatinine can be improved. It is shown that the meflunidone has a treatment effect on the AKI, that is, the medicine prepared from the meflunidone is suitable for treating the AKI. The administration dosage of the meflunidone to a human body is 12.8 mg / kg.
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Description

technical field

[0001] The present invention relates to ZHC-116, 1-(4-((3-(4-methylpiperazin-1-yl)propyl)amino)benzyl)-5-(trifluoromethyl)pyridine-2(1H )-ketone (abbreviated as meflunidone) new medical application. Background technique

[0002] Acute kidney injury (AKI) is a common clinical syndrome, its occurrence is often accompanied by prolonged hospitalization, and some patients with poor prognosis will further develop into chronic kidney disease. About 13 million people worldwide suffer from AKI every year (85% of patients live in developing countries), and about 1.7 million people die from AKI and its complications. AKI can occur in many clinical disciplines, especially in the ICU with an incidence of more than 50%. In my country, a large-sample multi-center epidemiological survey data showed that according to the diagnostic criteria and extended criteria of KDIGO AKI, the incidence of AKI was 0.99% and 2.03%, while the in-hospital mortality rate was as high as 12.4%...

Claims

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