Traditional Chinese medicine composition for improving renal functions and restraining renal fibrosis

A composition and kidney function technology, applied in the direction of drug combination, pharmaceutical formula, plant raw materials, etc., can solve the problems of unsatisfactory effect, anti-renal fibrosis limited to the animal experiment stage, etc., achieve excellent curative effect, improve kidney function and trace Proteinuria, the effect of inhibiting expression

Inactive Publication Date: 2014-01-01
SHUGUANG HOSPITAL AFFILIATED WITH SHANGHAI UNIV OF T C M
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  • Abstract
  • Description
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  • Application Information

AI Technical Summary

Problems solved by technology

But its effect is not ideal, and it is mostly limited to the stage of animal experiments
[0007] Judging from the current research, there is still room for development of its pathogenesis, and most of the current anti-renal fibrosis treatments are still limited to the animal experiment stage, and there is still a long way to go before entering the clinic, and the curative effect still needs further research. improve

Method used

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  • Traditional Chinese medicine composition for improving renal functions and restraining renal fibrosis
  • Traditional Chinese medicine composition for improving renal functions and restraining renal fibrosis
  • Traditional Chinese medicine composition for improving renal functions and restraining renal fibrosis

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0035] Experimental example one clinical study

[0036] 1.1 Case selection

[0037] Case selection criteria: Apply the principle of randomization to select patients with clinically diagnosed renal insufficiency (CRF) whose GFR (Glomerular Filtration Rate) is 30~90ml / (min·1.73m) 2 ). Among them, 86 were males and 82 were females, aged 26-73 years, with an average age of 51.5 years. The primary disease was primary chronic glomerulonephritis. Renal biopsy in some patients suggested renal tissue pathological IgA nephropathy, mesangial proliferative nephritis, Focal stage sclerosing nephritis, etc. There is no significant difference in general data and observation indexes between the treatment group of the traditional Chinese medicine composition of the present invention and the basic control group (p>0.05).

[0038] 1.2 Treatment methods

[0039] Basic treatment: Before treatment, alleviate various factors that induce and aggravate renal failure, such as infection, electrolyte imbalance...

experiment example 2

[0075] Experimental example two, animal experiment research

[0076] (1) Study on the effect of the Chinese medicine composition of the present invention on improving renal fibrosis

experiment example 1

[0077] Experimental example 1: Study on renal function and microalbuminuria of CRF rats with Platt's 5 / 6 nephrectomy

[0078] 1Materials and methods

[0079] 1.1 Experimental medicine: The traditional Chinese medicine composition of the present invention is made into a water decoction by the preparation room of our hospital.

[0080] 1.2 Experimental animals and modeling methods: 100 SD male rats (180-200g) were raised in separate cages at room temperature. After 1 week, 5 / 6 nephrectomy was performed by Platt method as a rat model of chronic renal failure, divided into two stages After completion, 2 / 3 of the left kidney was removed by a back incision, and the entire right kidney was removed one week later. In the sham operation group, only the back incision was used to peel off the left and right renal capsules in two separate steps to preserve the adrenal glands.

[0081] 1.3 Animal grouping and treatment methods: Divided into 4 groups, sham operation control group "A" 10 animals; m...

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Abstract

The invention discloses a traditional Chinese medicine composition for improving renal functions and restraining renal fibrosis. Active pharmaceutical ingredients of the traditional Chinese medicine composition comprise, by weight, 10-15 parts of the root of red-rooted salvia, 10-60 parts of astragalus membranaceus, 10-30 parts of herba epimedii, 5-30 parts of sinensis and 3-30 parts of prepared rhubarb. Clinical researches show that 168 patients with chronic renal insufficiency are treated by the traditional Chinese medicine composition, a remarkable clinical effect is obtained, clinical symptoms are reduced, the clinical symptoms of some patients are basically eliminated, the renal functions of the patients can be remarkably improved, blood urea nitrogen (BUN) and creatinine (Scr) are obviously reduced, and total effective rate achieves 88.66%. Animal researches show that the traditional Chinese medicine composition can delay development of chronic renal failure, and the mechanism of the traditional Chinese medicine composition is relative to effects of effectively restraining precipitation of renal tissue collagen and secretion of TGF (transforming growth factor)-beta, accordingly restraining renal fibrosis, and the like. The traditional Chinese medicine composition is low in clinical application cost and excellent in curative effect, and is safe and reliable.

Description

Technical field [0001] The invention belongs to the field of traditional Chinese medicine, and specifically relates to a traditional Chinese medicine composition, in particular to a traditional Chinese medicine composition for improving renal function and inhibiting renal tissue fibrosis. technical background [0002] Chronic kidney disease (CKD) is a major disease that seriously endangers human health. It is currently increasing at an alarming rate worldwide. On February 20, 2007, the International Society of Nephrology News Announcement: At present, more than 500 million people in the world suffer from different kidney diseases, and more than one million people die from CKD-related cardiovascular and cerebrovascular diseases every year. CKD has become another important disease threatening human health after cardiovascular and cerebrovascular diseases, tumors, and diabetes. It has become a global public health problem and a new epidemic. In terms of global conditions, the incid...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/708A61P13/12
Inventor 何立群郑平东邵命海王东
Owner SHUGUANG HOSPITAL AFFILIATED WITH SHANGHAI UNIV OF T C M
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