Medical suppository for treating chronic nephrosis and preparation method thereof

A technology for chronic kidney disease and drugs, which is applied in drug combinations, pharmaceutical formulas, and medical raw materials derived from molluscs. It can solve the problems of patients with diarrhea, complicated operations, and patient pain, so as to improve absorption, avoid side effects, and have definite curative effects. Effect

Inactive Publication Date: 2015-08-12
姚清
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, rhubarb is cold in nature and has a significant purging effect, and it is easy to cause diarrhea in patients during enema
At the same time, although the curative effect of enema therapy is obvious, the operation is complicated and must be completed by a doctor in the hospital, requiring a high degree of cooperation from the patient, which will bring psychological and physical pain to the patient.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Weigh the following raw materials: rhubarb 6g, salvia miltiorrhiza 20g, Liuyuexue 20g, raw oyster 20g, tin leisan 6g.

[0026] Prepare as follows:

[0027] (1) Rhubarb is crushed, added in 120ml of 70% acetone aqueous solution, ultrasound is advanced 20min, extracted twice, and the extract is combined; the extract is concentrated under reduced pressure, acetone is reclaimed, filtered, and the filtrate is taken; the filtrate is placed on Sephadex LH- 20 gel chromatographic column, eluted with water, 30% methanol aqueous solution, 50% methanol aqueous solution, 70% methanol aqueous solution respectively, got 50% methanol aqueous solution and 70% methanol aqueous solution eluent; Press to recover methanol and water to obtain a thick paste, and microwave drying to obtain rhubarb dry extract;

[0028] (2) Pulverize salvia miltiorrhiza, Liuyuexue, raw oyster, reflux extraction with 1200ml of 80% ethanol, extract for 2 hours, filter, keep the dregs, collect the ethanol extrac...

Embodiment 2

[0032] Weigh the following Chinese medicinal materials: rhubarb 9g, salvia miltiorrhiza 24g, Liuyuexue 24g, raw oyster 24g, tin leisan 9g.

[0033] Prepare as follows:

[0034] (1) Rhubarb is pulverized, added in 180ml of 70% acetone aqueous solution, ultrasound is advanced 20min, extracted twice, and the extract is combined; the extract is concentrated under reduced pressure, acetone is recovered, filtered, and the filtrate is taken; the filtrate is placed on Sephadex LH- 20 gel chromatographic column, eluted with water, 30% methanol aqueous solution, 50% methanol aqueous solution, 70% methanol aqueous solution respectively, got 50% methanol aqueous solution and 70% methanol aqueous solution eluent; Press to recover methanol and water to obtain a thick paste, and microwave drying to obtain rhubarb dry extract;

[0035] (2) Grind the salvia miltiorrhiza, Liuyuexue, and raw oysters, extract with 1420ml of 80% ethanol under reflux, extract for 2 hours, filter, keep the dregs, c...

Embodiment 3

[0039] Weigh the following Chinese medicinal materials: rhubarb 12g, salvia miltiorrhiza 30g, Liuyuexue 30g, raw oyster 30g, tin leisan 10g.

[0040] Prepare as follows:

[0041] (1) Rhubarb is pulverized, added in 240ml of 70% acetone aqueous solution, ultrasound is advanced 20min, extracted twice, and the extract is combined; the extract is concentrated under reduced pressure, acetone is reclaimed, filtered, and the filtrate is taken; the filtrate is placed on Sephadex LH- 20 gel chromatographic column, eluted with water, 30% methanol aqueous solution, 50% methanol aqueous solution, 70% methanol aqueous solution respectively, got 50% methanol aqueous solution and 70% methanol aqueous solution eluent; Press to recover methanol and water to obtain a thick paste, and microwave drying to obtain rhubarb dry extract;

[0042] (2) Pulverize salvia miltiorrhiza, Liuyuexue, raw oyster, reflux extraction with 1800ml of 80% ethanol, extract for 2 hours, filter, keep the dregs, collect...

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PUM

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Abstract

The invention discloses medical suppository for treating chronic nephrosis and a preparation method thereof. The medical suppository comprises, by weight, 6-12 parts of rheum officinale, 20-30 parts of red sage root, 20-30 parts of serissa serissoide, 20-30 parts of raw oyster and 6-10 parts of tin-like powder. The preparation method comprises the following steps of crushing rheum officinale, adding the crushed rheum officinale into an acetone aqueous solution with content of 70%, wherein the amount of the acetone aqueous solution is 20 times that of the rheum officinale powder, carrying out ultrasonic extraction two times, merging extract, carrying out condensation and filtration on the extract, collecting the filtrate, carrying out elution on the filtrate by a column chromatography method, carrying out elution by a methanol aqueous solution with content of 50-70%, carrying out condensation to obtain rheum officinale extract, carrying out extraction on other medical raw materials by ethanol with content of 80%, carrying out water extraction, carrying out filtration, drying the extract to obtain dry extract, merging the rheum officinale dry extract and other medical raw material extract, adding tin-like powder into the mixed extract, carrying out fine grinding, adding the powder into S-40, carrying out uniform grinding, and carrying out cast pouring. The medical suppository has the advantages of definite therapeutic effect, small side effect and use convenience.

Description

technical field [0001] The invention relates to a traditional Chinese medicine, in particular to a medicine suppository for treating chronic kidney disease and a preparation method thereof. Background technique [0002] Chronic kidney disease CKD (Chronic Kidney Dielace): chronic kidney structure and dysfunction caused by various reasons, including normal and abnormal pathological damage of glomerular filtration rate (GFR, glomerular filtration rate), abnormal blood or urine components , and imaging abnormalities, or unexplained decrease in GFR (less than 60ml / min·1.73m 2 ) for more than 3 months, it is CKD. The diseases that cause chronic kidney disease include various primary and secondary glomerulonephritis, renal tubular injury and renal vascular lesions. According to GFR, chronic kidney disease can be divided into 5 stages. Early detection and early intervention can significantly reduce the complications of CKD patients and significantly improve the survival rate. For ...

Claims

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Application Information

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IPC IPC(8): A61K36/708A61K36/74A61K9/02A61P13/12A61K35/618
Inventor 姚清
Owner 姚清
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