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Application of bioactive peptide in preparation of medicine for preventing and treating anthracycline cardiotoxicity

A technology of bioactive peptides and cardiotoxicity, applied in drug combinations, pharmaceutical formulations, cardiovascular system diseases, etc., can solve the problems of lack of safety and effectiveness, adverse reactions, high prices, etc., and achieve improved survival rate, easy absorption, and high safety Effect

Pending Publication Date: 2021-11-26
河南省医药科学研究院
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] The existing cardiotoxic protective agent of anthracyclines, dextropropylimine, can only be administered by injection, the price is high, and there are relatively serious adverse reactions. In order to solve the problem of lack of safe and effective anthracyclines protective agents, The present invention proposes new functions of biologically active peptides, which are embodied in the application in the preparation of drugs for preventing and treating cardiotoxicity of anthracyclines

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  • Application of bioactive peptide in preparation of medicine for preventing and treating anthracycline cardiotoxicity
  • Application of bioactive peptide in preparation of medicine for preventing and treating anthracycline cardiotoxicity
  • Application of bioactive peptide in preparation of medicine for preventing and treating anthracycline cardiotoxicity

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Embodiment Construction

[0029] In the following, the present invention will be described in more detail through specific embodiments, so as to facilitate the understanding of the technical solution of the present invention, but it is not used to limit the protection scope of the present invention.

[0030] The invention provides the application of biologically active peptides in the prevention and treatment of cardiotoxic drugs of anthracyclines.

[0031] As a possible embodiment, the bioactive peptide is albumin peptide, wheat oligopeptide, soybean peptide or corn oligopeptide.

[0032] As an embodiment, the anthracycline is doxorubicin or daunorubicin.

[0033] As an embodiment, the drug for preventing and treating cardiotoxicity of anthracyclines is a drug for preventing and treating the reduction of left ventricular ejection fraction and / or left ventricular short-axis shortening rate caused by anthracyclines.

[0034] As a possible embodiment, the drug for preventing and treating cardiotoxicity ...

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Abstract

The invention belongs to the technical field of medicines for preventing and treating cardiotoxicity, and particularly relates to application of bioactive peptide in preparation of a medicine for preventing and treating anthracycline cardiotoxicity, wherein the bioactive peptide is albumin peptide, wheat oligopeptide, soybean peptide or corn oligopeptide; and the anthracycline medicine is adriamycin or daunorubicin. The biological functions of the albumin peptide, the wheat oligopeptide, the soybean peptide and the corn oligopeptide except for oxidation resistance and tumour resistance are found in the invention; the application range of the bioactive peptide is expanded; and the bioactive peptide in the invention has a remarkable effect on preventing and treating the anthracycline cardiotoxicity and has no side effect.

Description

technical field [0001] The invention relates to the technical field of medicines for preventing and treating cardiotoxicity, in particular to the application of bioactive peptides in the preparation of medicines for preventing and treating cardiotoxicity of anthracyclines. Background technique [0002] Anthracyclines refer to a class of chemotherapy drugs containing anthracyclines, including doxorubicin (doxorubicin), epirubicin (epirubicin), birubicin, daunorubicin, arubicin Star, Idabi star and so on. This type of drug has been clinically used to treat hematological malignancies and solid tumors, including acute leukemia, lymphoma, breast cancer, ovarian cancer, gastric cancer and soft tissue sarcoma, etc., for half a century, and is a milestone class of drugs Even with the emergence of new therapies such as targeted therapy and immunotherapy, it is still the basic drug for the treatment of many hematological malignancies and solid tumors because of its broad anti-tumor e...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/38A61K38/01A61K38/02A61P9/00
CPCA61K38/38A61K38/011A61K38/02A61P9/00
Inventor 张丽果何美霞游普云朱奎成何航姜山朱建立李志刚
Owner 河南省医药科学研究院
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