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Silver ion-containing chlorhexidine salt compound as well as preparation method and application thereof

A salt compound, chlorhexidine technology, applied in the direction of botanical equipment and methods, applications, biocides, etc., can solve the problems of poor bactericidal and antibacterial effects, short antimicrobial action time, etc.

Active Publication Date: 2021-12-17
洛阳冠银生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The object of the present invention is to provide a kind of silver ion-containing chlorhexidine salt compound, which is used to solve the problem of poor sterilization and antibacterial effect caused by short antimicrobial action time when the current chlorhexidine salt solution is used

Method used

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  • Silver ion-containing chlorhexidine salt compound as well as preparation method and application thereof
  • Silver ion-containing chlorhexidine salt compound as well as preparation method and application thereof
  • Silver ion-containing chlorhexidine salt compound as well as preparation method and application thereof

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Embodiment 1

[0037] The structural formula of the silver ion-containing chlorhexidine salt compound of the present embodiment is that the structural formula is A n (B) mC, wherein A is chlorhexidine, and B is a compound containing group D and group E simultaneously, and C It is a compound containing a carboxyl group, n is 3, m is 0, the group D is -COOH, and the group E is -COOAg; the compound B is obtained by reacting malonic acid and silver nitrate in a molar ratio of 1:1.

Embodiment 2

[0039] The structural formula of the silver ion-containing chlorhexidine salt compound of the present embodiment is that the structural formula is A n (B) mC, wherein A is chlorhexidine, and B is a compound containing group D and group E simultaneously, and C It is a compound containing a carboxyl group, n is 2, m is 0, the group D is -COOH, and the group E is -COOAg; the compound B is obtained by reacting malic acid and silver nitrate in a molar ratio of 1:1.

Embodiment 3

[0041] The structural formula of the silver ion-containing chlorhexidine salt compound of the present embodiment is that the structural formula is A n (B) mC, wherein A is chlorhexidine, and B is a compound containing group D and group E simultaneously, and C It is a compound containing a carboxyl group, n is 1, m is 0, the group D is -COOH, and the group E is -COOAg; the compound B is obtained by reacting citric acid and silver nitrate in a molar ratio of 1:1.

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Abstract

The invention relates to a chlorhexidine salt compound containing silver ions as well as a preparation method and application thereof, and belongs to the technical field of antimicrobial agents. According to the chlorhexidine salt compound containing the silver ions, the structural formula of the chlorhexidine salt compound containing the silver ions is A.n(B).mC, wherein A is chlorhexidine, B is a compound containing a group D and a group E at the same time, C is a compound containing carboxyl, n is 1 or 2 or 3 or 4, m is 0 or 1 or 2 or 3, the sum of m and n is less than or equal to 4, the group D is -COOH, and the group E is -COOAg. The chlorhexidine salt compound containing the silver ions is used as an antimicrobial agent, the compound contains a chlorhexidine structure and the silver ions at the same time, the chlorhexidine structure has a rapid sterilization function, and the silver ions have a long-acting antibacterial function; therefore, the chlorhexidine salt compound containing the silver ions has the dual functions of rapid sterilization and long-acting antibiosis.

Description

technical field [0001] The invention relates to a silver ion-containing chlorhexidine salt compound and a preparation method and application thereof, belonging to the technical field of antimicrobial agents. Background technique [0002] Chlorhexidine is a well known antimicrobial agent used in various medical applications. These medical applications include skin cleansing preparations, hand sanitizers and gargles, others that are effective against Gram-positive and Gram-negative bacteria and many yeasts. [0003] Because chlorhexidine itself is insoluble in water, common products are used or sold as hydrochloride or acetate. When chlorhexidine hydrochloride or acetate is used as a fungicide, these chlorhexidine salt compounds exert a bactericidal effect by contacting the infected area, but the chlorhexidine salt solution is easy to lose, and its antimicrobial action time is short , so the antimicrobial effect of chlorhexidine salt solution is also limited, not easy to con...

Claims

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Application Information

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IPC IPC(8): A01N47/44A01N59/16A01P3/00A01P1/00
CPCA01N47/44A01N59/16Y02A50/30
Inventor 张玉清李治通李翊帆张航魏鑫任军甫
Owner 洛阳冠银生物科技有限公司
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