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Preparation method of visual antibacterial and anti-inflammatory dressing for treating bacterial infection type wounds

A technology for bacterial infection and wounds, applied in bandages, absorbent pads, medical science, etc., can solve the problems of bacterial death, membrane damage, and unsolved problems, achieve healing promotion, reduce crystallinity, and be beneficial to antibacterial, anti-inflammatory and healing effect

Active Publication Date: 2021-12-21
NORTHWEST UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, there is no effective clinical dressing for bacterial infection wounds. Positively charged cationic polymers can cause membrane damage and bacterial death, which has attracted the attention of researchers. However, how to optimize the bactericidal performance of hydrogel dressings based on In terms of improving the adhesion and light transmittance of hydrogel dressings, it has not been effectively solved

Method used

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  • Preparation method of visual antibacterial and anti-inflammatory dressing for treating bacterial infection type wounds
  • Preparation method of visual antibacterial and anti-inflammatory dressing for treating bacterial infection type wounds
  • Preparation method of visual antibacterial and anti-inflammatory dressing for treating bacterial infection type wounds

Examples

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Effect test

Embodiment 1

[0045] This embodiment provides a method for preparing a visualized antibacterial and anti-inflammatory dressing for bacterial infection wound treatment, including the following steps:

[0046] Step 1. Dissolve polyvinyl alcohol and borax in water at a temperature of 80°C until completely clarified to obtain a mixed solution I; in the mixed solution I, the mass percentage of polyvinyl alcohol is 9%, and the mass percentage of borax is 100%. Min content is 5%; The number average molecular weight of described polyvinyl alcohol is 80000, and the relative molecular weight of described borax is 300;

[0047]Step 2. Under normal temperature conditions, dissolve 1-vinyl-3-butylimidazolium bromide and ammonium persulfate in water until completely clear to obtain a mixed solution II; in the mixed solution II, 1-vinyl-3 - The mass percentage of butyl imidazolium bromide is 5%, the mass percentage of ammonium persulfate is 0.2%; the molecular weight of the 1-vinyl-3-butyl imidazolium bro...

Embodiment 2

[0084] This embodiment provides a method for preparing a visualized antibacterial and anti-inflammatory dressing for bacterial infection wound treatment, comprising the following steps:

[0085] Step 1, under the temperature condition of 100 DEG C, dissolve polyvinyl alcohol and borax in water until completely clarified to obtain a mixed solution I; in the mixed solution I, the mass percentage of polyvinyl alcohol is 4%, and the mass percentage of borax is 100%. Min content is 3%; The number average molecular weight of described polyvinyl alcohol is 100000, and the relative molecular weight of described borax is 400;

[0086] Step 2. Under normal temperature conditions, dissolve 1-vinyl-3-butylimidazolium bromide and ammonium persulfate in water until completely clear to obtain a mixed solution II; in the mixed solution II, 1-vinyl-3 - The mass percentage of butyl imidazolium bromide is 12%, the mass percentage of ammonium persulfate is 0.8%; the molecular weight of the 1-viny...

Embodiment 3

[0093] This embodiment provides a method for preparing a visualized antibacterial and anti-inflammatory dressing for bacterial infection wound treatment, comprising the following steps:

[0094] Step 1. Dissolve polyvinyl alcohol and borax in water at a temperature of 70°C until completely clarified to obtain a mixed solution I; in the mixed solution I, the mass percentage of polyvinyl alcohol is 15%, and the mass percentage of borax is 100%. Min content is 7%; The number average molecular weight of described polyvinyl alcohol is 95000, and the relative molecular weight of described borax is 450;

[0095] Step 2. Under normal temperature conditions, dissolve 1-vinyl-3-butylimidazolium bromide and ammonium persulfate in water until completely clear to obtain a mixed solution II; in the mixed solution II, 1-vinyl-3 - The mass percentage of butyl imidazolium bromide is 10%, the mass percentage of ammonium persulfate is 0.5%; the molecular weight of the 1-vinyl-3-butyl imidazolium...

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Abstract

The invention discloses a preparation method of a visual antibacterial and anti-inflammatory dressing for treating bacterial infection type wounds, which comprises the following steps: S1, dissolving polyvinyl alcohol and borax in water to obtain a mixed solution I; S2, dissolving 1-vinyl-3-butylimidazolium bromide and ammonium persulfate in water so as to obtain a mixed solution II; S3, filling nitrogen into the mixed solution II; S4, performing a polymerization reaction on the mixed solution II filled with the nitrogen so as to obtain a polyion liquid solution II; S5, mixing the mixed solution I with the polyion liquid solution II to obtain a dressing preparation solution; and S6, pouring the dressing preparation solution into a die, and carrying out circulating low-temperature freezing processing to obtain the visual antibacterial and anti-inflammatory dressing. The visual antibacterial and anti-inflammatory dressing prepared by the method disclosed by the invention has the characteristics of high light transmittance, excellent antibacterial performance and anti-inflammatory performance, good skin adhesion self-healing performance and good promotion effect on healing of the bacterial infection type wounds.

Description

technical field [0001] The invention belongs to the technical field of biomedical materials, and in particular relates to a preparation method of a visualized antibacterial and anti-inflammatory dressing for bacterial infection wound treatment. Background technique [0002] The common manifestations of wound bacterial infection include local redness and swelling, elevated skin temperature, accompanied by certain pain or swelling, and severe throbbing pain, which affects the normal life and sleep of patients. Bacterial infection of the wound seriously delays the healing process, and if it is not treated in time, it may lead to sepsis, toxemia, septic shock, and even life-threatening. [0003] The wound healing process can be divided into four steps: hemostasis, inflammation, hyperplasia, and remodeling. After an injury, the skin's epidermal barrier breaks down, and the injured area becomes a breeding ground for bacterial growth and infection, disrupting the healing process. ...

Claims

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Application Information

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IPC IPC(8): A61L15/24A61L15/18A61L15/20A61L15/42A61L15/44A61L15/46C08F126/06C08F4/30
CPCA61L15/24A61L15/18A61L15/20A61L15/42A61L15/44A61L15/46C08F126/06C08F4/30A61L2300/404A61L2300/412A61L2300/41A61L2300/202C08L29/04
Inventor 朱晨辉范代娣刘斌傅容湛邓建军
Owner NORTHWEST UNIV
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