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Screening method of water-soluble composite vaccine adjuvant

A water-soluble compound and vaccine adjuvant technology, applied in the field of bioengineering, can solve the problems of weak immunogenicity of the new type, and achieve the effect of easy promotion, complete detail design and good applicability

Pending Publication Date: 2021-12-24
QINGDAO AGRI UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] The technical problem to be solved by the present invention is that the novel immunogenicity is relatively weak, it cannot induce a strong immune effect in vivo, and only by relying on vaccine adjuvants can it be induced to produce strong humoral immunity and cellular immune response

Method used

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  • Screening method of water-soluble composite vaccine adjuvant
  • Screening method of water-soluble composite vaccine adjuvant
  • Screening method of water-soluble composite vaccine adjuvant

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Embodiment Construction

[0038] The present invention will be described in further detail below in conjunction with the accompanying drawings.

[0039]When the present invention is implemented, a screening method for a water-soluble composite vaccine adjuvant comprises the following steps:

[0040] Step 1. Immunization test of primary adjuvant on mice. Firstly, OVA and single-component vaccine adjuvant were immunized into mice by subcutaneous injection, and Quil A, which proved to have a good adjuvant effect after a large number of clinical trials, was selected as a positive control The immunization procedure was as follows: the ICR mice were randomly divided into 10 groups, and a blank control group was set up, with 8 mice in each group and numbered in groups, with OVA as the antigen, and each test group was injected with the corresponding adjuvant, which was the first immunization (section 0d), the second immunization is carried out on the 14th day after the first immunization, and the sampling test...

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Abstract

The invention discloses a screening method of a water-soluble composite vaccine adjuvant. The screening method comprises the following steps: step 1, performing an immune test on a mouse by using a primarily selected adjuvant; step 2, optimizing a drug combination adjuvant dosage screening test; and step 3, performing a screening test conforming to an adjuvant formula. Compared with the prior art, the screening method has the advantages that the test steps are clear and reasonable, the selected reagent fits the reality, the test is standard, the detail design is complete, and the screened composite vaccine adjuvant can enhance the immune response of ICR mice through preliminary research verification, has certain research value, is good in applicability and is convenient to popularize.

Description

technical field [0001] The invention relates to bioengineering, in particular to a screening method for a water-soluble compound vaccine adjuvant. Background technique [0002] Vaccine is one of the most important, efficient, economical and convenient effective measures to control animal diseases in animal husbandry production practice. With the development of science and technology, various new vaccines are continuously applied to actual production. Compared with traditional vaccines, they have the advantages of safety and reliability. Vaccine Adjuvant, also known as adjuvant or antigen adjuvant, is a class of substances that can non-specifically change or enhance the body’s specific immune response to antigens, play an auxiliary role, and have no antigenic properties themselves. It can enhance the immune performance of the vaccine, improve the self-protection ability of the immunized body, and reduce the dosage and cost of the vaccine. In this study, Platycodon tenuifoli...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K49/00A61K39/39A61P37/04
CPCA61K49/0008A61K39/39A61P37/04A61K2039/575A61K2039/55577A61K2039/55516A61K2039/55511
Inventor 黄娟单虎
Owner QINGDAO AGRI UNIV
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