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Systems and methods for probe angle adjustment in bioreactors

A technology of reactors and reaction chambers, applied to specific-purpose bioreactors/fermenters, biochemical equipment and methods, bioreactor/fermenter combinations, etc., which can solve the problems of unmaintainable probe angle, yield change, and air bubble entrapment And other issues

Pending Publication Date: 2021-12-24
CYTIVA SWEDEN AB
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Also, this fixed arrangement of the sensing probes results in air bubble entrapment, and the operator cannot maintain the probe angle, causing yield variation across batches
Accordingly, current methods for mounting sensing probes within disposable bags suffer from a number of disadvantages

Method used

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  • Systems and methods for probe angle adjustment in bioreactors
  • Systems and methods for probe angle adjustment in bioreactors
  • Systems and methods for probe angle adjustment in bioreactors

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Embodiment Construction

[0022] The following detailed description of the exemplary embodiments refers to the accompanying drawings. The same reference numbers in different drawings identify the same or similar elements. Additionally, the drawings are not necessarily drawn to scale. Also, the following detailed description does not limit the invention. Rather, the scope of the invention is defined by the appended claims.

[0023] Reference throughout this specification to "one embodiment" or "another embodiment" or "some embodiments" means that a particular feature, structure, or characteristic described in connection with the embodiments is included in at least one implementation of the disclosed subject matter. example. Thus, the appearances of the phrase "in one embodiment" or "in an embodiment" or "in some embodiments" in various places throughout this specification are not necessarily referring to the same embodiment(s). Furthermore, the particular features, structures or characteristics may ...

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PUM

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Abstract

Systems (100, 700) and a method for probe angle adjustment in bioreactor vessels are provided. The system (100) comprises a reactor vessel (110) having a reaction chamber (113), wherein the reaction chamber (113) has at least one opening (111). A probe support bar assembly (200, 300) is mounted on the reactor vessel (110), and a sensing probe (114) is mounted on the probe support bar (112), and the sensing probe (114) passes through the opening (111) on the reaction chamber (113). The movement of the probe support bar assembly (200, 300) changes the angle of inclination of sensing probe (114) inside the reaction chamber (113).

Description

technical field [0001] Embodiments of the present specification relate generally to adjusting the angle of a probe support assembly in a bioreactor, and more particularly to systems and methods for an adjustable angle probe support assembly for use in The sensing probe is inserted into the interior of the bioreactor at an angle. Background technique [0002] Bioreactors are widely used in the biomanufacture of biotechnological products. Multiple-use bioreactors generally require large capital investments for purchase and installation, validated procedures for cleaning and sterilization, and skilled personnel for operation and maintenance. For this reason, single-use bioreactors or single-use bags are increasingly being used in smaller volume operations. Single-use or disposable bags are usually made of three-layer plastic and the bags are pre-sterilized before being installed in the bioreactor. [0003] Several parameters of the process fluid within the disposable bag are...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12M1/34C12M1/00
CPCC12M23/48C12M41/00C12M41/48C12M23/14C12M27/02
Inventor P·Y·基尼S·阿格尼霍特里S·C·尼V·穆昆特拉吉S·茨P·巴吉亚纳塔安K·穆鲁格桑
Owner CYTIVA SWEDEN AB
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