Compound with anti-epileptic activity and application thereof in preparation of anti-epileptic drugs
A technology of antiepileptic drugs and compounds, applied in the direction of steroids, organic active ingredients, medical preparations containing active ingredients, etc., can solve the problem of antiepileptic activity research without chemical ingredients
Active Publication Date: 2022-01-25
LANZHOU INST OF CHEM PHYSICS CHINESE ACAD OF SCI +1
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However, no studies have been conducted on the antiepi
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[0033] Based on the above research results, at least one compound of ingenane type diterpene GS-22, GS-54, jatrophane type diterpene GS-70, GS-71, and euphorane type triterpene GS-45 is Active substances, and prepared into oral preparations, such as capsules, tablets, granules, etc., according to pharmaceutically acceptable auxiliary materials and standard processes. It can also be used as a functional ingredient to prepare functional food.
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The invention provides a compound with anti-epileptic activity, the compound is extracted and separated from euphorbia kansui, and the compound comprises two ingenane type diterpenes (GS-22 and GS-54), two jatrophane type diterpenes (GS-70 and GS-71) and one euphorbia type triterpenes (GS-45). Pharmacological experiments show that the five compounds can significantly reduce the discharge frequency of hippocampal neurons under the administration concentration of 10 micromoles (M), and have potential anti-epileptic activity. Meanwhile, under the detection concentration, the five compounds do not influence the action potential amplitude, the half-peak width and the membrane potential level. It indicates that the five compounds can be used for preparing medicines for preventing and treating epilepsy diseases.
Description
technical field [0001] The present invention relates to a compound with anti-epileptic activity extracted and separated from the summer solstice grass, and its anti-epileptic activity is studied through the spontaneous discharge effect of the compound on rat hippocampal neurons, in order to be used in the preparation of anti-epileptic drugs, belonging to The field of plant medicine and health care. Background technique [0002] Epilepsy, commonly known as "shorn wind" or "epilepsy", is a chronic disease in which the sudden abnormal discharge of brain neurons leads to transient brain dysfunction. Manifested as motor, sensory, consciousness, spirit, autonomic and other disorders. The neuroelectrophysiological basis of epilepsy is excessive synchronous discharge of neurons, and its abnormal discharge is mainly related to neurotransmitters, ion channels, glial cells, synaptic connections, and genetic and immune system abnormalities (Löscher et al., Pharmacol Rev.2020 ;72(3):60...
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Login to view more IPC IPC(8): C07D317/60C07J9/00C07C13/68C07C7/10C07C7/135A61K31/357A61K31/575A61K31/235A61P25/08A23L33/105
CPCC07D317/60C07J9/00C07C13/68A61P25/08A23L33/105A23V2002/00A23V2200/322A23V2250/21
Inventor 杨军丽高召兵郑月明孟宪华许海燕
Owner LANZHOU INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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