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New indications of application of tripeptide compound and copper ion chelate thereof

A technology of peptide compounds and copper ions, applied in tripeptide components, drug combinations, respiratory diseases, etc., to improve lung function, improve acute airway inflammation, inhibit collagen deposition and fibrosis

Pending Publication Date: 2022-01-28
CHINA JAPAN FRIENDSHIP HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, to date, no studies have examined the effect of GHK-Cu on bronchial asthma other than the present patent applicant

Method used

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  • New indications of application of tripeptide compound and copper ion chelate thereof
  • New indications of application of tripeptide compound and copper ion chelate thereof
  • New indications of application of tripeptide compound and copper ion chelate thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Example 1 The correlation between plasma GHK level and airway remodeling and disease severity in asthmatic patients was analyzed.

[0028] Medical history, bronchodilation test and FeNo results, blood eosinophil count and IgE level, and lung HRCT were collected from age-sex-paired asthmatic patients and healthy volunteers, whose plasma was collected and analyzed by stability-indicating reversed-phase high-performance liquid chromatography (RP- HPLC) method was used to quantitatively analyze the level of GHK, and the correlation between plasma GHK level and airway remodeling and disease severity in asthmatic patients was analyzed. Such as figure 1 shown.

[0029] In patients with bronchial asthma, serum GHK level was positively correlated with lung function FVC and FEV1 (r=0.5+) and the p value was statistically significant.

Embodiment 2

[0030] Example 2 Establishment of mouse asthma model, evaluation of GHK-Cu therapeutic effect.

[0031]1. Mice rearing and asthma model establishment: BALB / c wild-type female mice (6-8 weeks old) were fed in an environment with controlled temperature and humidity, with a 12-h day-night cycle. They were randomly divided into 6 groups (n=6), namely blank group, OVA group, OVA+low-dose GHK-Cu (0.2mg / Kg) group, OVA+medium-dose GHK-Cu (2mg / Kg) group, OVA+high-dose GHK- Cu (20mg / Kg) group, OVA+glucocorticoid (DEXA) (2mg / Kg) group. Except for the blank group, the other groups were sensitized by intraperitoneal injection of OVA on days 0 and 14, then administered OVA via airway aerosol inhalation for 30 min / day for 18 consecutive days from the 24th day, before aerosol inhalation of OVA At 1 hour, the GHK-Cu group was given the corresponding dose of GHK-Cu by intraperitoneal injection, the DEXA group was given glucocorticoids, and the blank group was given PBS instead of stimulation a...

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Abstract

The invention relates to the field of treatment of acute and chronic bronchial asthma, in particular to application of a tripeptide-based compound and a copper ion chelate thereof in treatment of bronchial asthma. Experiments prove that the tripeptide compound GHK (glycyl-L-histidine-L-lysine) and the copper ion chelate of the tripeptide compound GHK can play a protective role in acute and chronic bronchial asthma by resisting inflammation, regulating immunity, resisting oxidation and reversing an epithelial cell mesenchymal phenomenon.

Description

technical field [0001] The present invention relates to the field of treatment of acute and chronic bronchial asthma, in particular to the application of a tripeptide compound and its copper ion chelate in the treatment of bronchial asthma, especially through anti-inflammation, immune regulation, anti-oxidation and reversal of epithelial cells Mesenchymal phenomenon, which in turn plays a protective role in acute and chronic bronchial asthma. Background technique [0002] Asthma is a chronic airway disease characterized by airway hyperresponsiveness, inflammation, and airway remodeling, with prominent pathological features including periairway eosinophilic or neutrophil inflammation, subepithelial fibrosis, and thickening of airway smooth muscle , mucus hypersecretion and goblet cell hyperplasia and metaplasia. [0003] In the past, airway remodeling was considered to be the result of long-term chronic airway inflammation. Today, this concept has changed, and airway remodel...

Claims

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Application Information

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IPC IPC(8): A61K38/06A61P11/06
CPCA61K38/06A61P11/06
Inventor 侯刚邓明明杨汀
Owner CHINA JAPAN FRIENDSHIP HOSPITAL
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