Application of miR-208a-3p antisense nucleic acid in treatment of myocardial ischemia reperfusion injury

1. The technology of mir-208a-3p and reperfusion injury, applied in the field of biomedicine, can solve problems such as unsatisfactory treatment effect, and achieve the effect of solving unsatisfactory treatment effect

Pending Publication Date: 2022-02-01
XIEHE HOSPITAL ATTACHED TO TONGJI MEDICAL COLLEGE HUAZHONG SCI & TECH UNIV
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  • Abstract
  • Description
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Problems solved by technology

[0005] In view of the above background, the present invention aims to solve the unsatisfactory technical problem of traditional myocardial ischemia-reperfusion injury drugs by proposing the application of miR-208a-3p antisense nucleic acid in the treatment of myocardial ischemia-reperfusion injury. Treatment of blood reperfusion injury opens up broader prospects

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  • Application of miR-208a-3p antisense nucleic acid in treatment of myocardial ischemia reperfusion injury
  • Application of miR-208a-3p antisense nucleic acid in treatment of myocardial ischemia reperfusion injury
  • Application of miR-208a-3p antisense nucleic acid in treatment of myocardial ischemia reperfusion injury

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Embodiment Construction

[0030] In order to enable those skilled in the art to understand the technical solution of the present invention more clearly, the technical solution of the present invention will be described in detail below in conjunction with specific embodiments.

[0031] 1. Establishment of the surgical model

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Abstract

The invention provides an application of the miR-208a-3p antisense nucleic acid in treatment of the myocardial ischemia reperfusion injury, and discloses an extraction method of the miR-208a-3p antisense nucleic acid. The treatment effect of the miR-208a-3p antisense nucleic acid in treatment of the myocardial ischemia reperfusion injury is determined through a mouse contrast experiment, the problem that a traditional myocardial ischemia reperfusion injury medicine is not ideal in treatment effect is solved, and a wider prospect is developed for treatment of myocardial ischemia reperfusion injury.

Description

Technical field: [0001] The invention relates to the field of biomedicine, in particular to the application of a miR-208a-3p antisense nucleic acid in the treatment of myocardial ischemia-reperfusion injury. Background technique: [0002] Myocardial ischemia-reperfusion injury (MIRI) refers to the pathology in which the ischemic myocardium recovers to normal perfusion when the coronary artery is partially or completely acutely blocked and recanalized within a certain period of time, but its tissue damage is progressively aggravated instead. process. A series of damaging changes in myocardial ultrastructure, energy metabolism, cardiac function, and electrophysiology caused by ischemia are more prominent after recanalization, and severe arrhythmias may even occur, leading to sudden death. Myocardial ischemia-reperfusion injury can occur in open-heart surgery, coronary artery bypass grafting, transluminal coronary angioplasty, post-thrombolysis, and sudden increase in blood vo...

Claims

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Application Information

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IPC IPC(8): A61K31/7088A61P9/10C07H21/04C07H1/00
CPCA61K31/7088A61P9/10C07H21/04C07H1/00Y02P20/55
Inventor 曾秋棠俞坤武丁焱
Owner XIEHE HOSPITAL ATTACHED TO TONGJI MEDICAL COLLEGE HUAZHONG SCI & TECH UNIV
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