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Compositions and methods of using the same for treatment of neurodegenerative and mitochondrial disease

A compound, C1-C4 technology, applied in nervous system diseases, drug combinations, active ingredients of heterocyclic compounds, etc., can solve problems such as poor prognosis, difficult to obtain compounds, and no cure

Pending Publication Date: 2022-02-08
MITOKININ INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

LS (and most diseases caused by mitochondrial dysfunction) have a poor prognosis; there is no cure and treatment is often ineffective
[0009] Despite the prevalence of disorders associated with the PINK1 pathway, compounds capable of selectively targeting this pathway and thus treating disorders associated with this pathway remain elusive

Method used

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  • Compositions and methods of using the same for treatment of neurodegenerative and mitochondrial disease
  • Compositions and methods of using the same for treatment of neurodegenerative and mitochondrial disease
  • Compositions and methods of using the same for treatment of neurodegenerative and mitochondrial disease

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Embodiment Construction

[0111] The present invention can be understood more readily by reference to the following detailed description of the invention and the Examples included therein.

[0112] Before the compounds, compositions, articles, systems, devices and / or methods of the present invention are disclosed and described, it is to be understood that they are not limited to particular synthetic methods (unless otherwise indicated) or particular reagents (unless otherwise indicated), and therefore These can of course vary. It is also to be understood that the terminology used herein is for the purpose of describing particular embodiments only and is not intended to be limiting. Although any methods and materials similar or equivalent to those described herein can be used in the practice or testing of the present invention, exemplary methods and materials are now described.

[0113] While specific statutory categories (such as system statutory categories) may be used to describe and claim embodimen...

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Abstract

The present disclosure is directed to nitrogen-containing heteroaryl analogs, methods of making nitrogen-containing analogs, and methods of treating disorders associated with PINK1 kinase activity including, but not limited to, neurodegenerative diseases, mitochondrial diseases, fibrosis, and / or cardiomyopathy using these analogs. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

Description

[0001] Cross References to Related Applications [0002] This application claims the benefit of U.S. Application No. 62 / 828,995, filed April 3, 2019, U.S. Application No. 62 / 879,794, filed July 29, 2019, and U.S. Application No. 62 / 933,632, filed November 11, 2019, The contents of these applications are hereby incorporated by reference in their entirety. [0003] Sequence Listing Citation [0004] The sequence listing filed on April 3, 2020 as a text file created on March 31, 2020 named "37930_0004P1_ST25.txt" and 15,539 bytes in size is hereby given pursuant to 37 C.F.R. §1.52(e)(5) Incorporated by reference. Background technique [0005] Maintenance of mitochondrial function is critical to the health and survival of numerous cell types including cardiomyocytes, hepatocytes, kidney cells and neurons. Abnormal mitochondrial quality control has been shown to be an important factor in the development of neurodegenerative, renal, and cardiomyopathy (Schapira, A.H. Mitochondria...

Claims

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Application Information

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IPC IPC(8): C07D487/04C07D471/04A61K31/435
CPCC07D487/04C07D471/04C07D473/34A61P25/28A61K31/519A61K31/52
Inventor D·德罗莱特J·巴塞洛缪斯S·约翰斯通R·M·钦N·T·赫兹R·德维塔
Owner MITOKININ INC
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