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Biomacromolecule detection method and device based on nano array structure

A biomacromolecule and nanoarray technology, applied in the field of biomacromolecule detection methods and devices based on nanoarray structures, can solve the problems that biomacromolecules are difficult to be detected quickly, achieve high accuracy, avoid physical and chemical reactions, and detect speed high effect

Pending Publication Date: 2022-02-15
NANJING UNIV OF SCI & TECH
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  • Abstract
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Problems solved by technology

[0004] The object of the present invention is to provide a biomacromolecule detection method based on a nanoarray structure, so as to solve the problem that biomacromolecules are difficult to be quickly detected in a low concentration state

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  • Biomacromolecule detection method and device based on nano array structure
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  • Biomacromolecule detection method and device based on nano array structure

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Embodiment Construction

[0025] In order to make the purpose, technical solutions and advantages of the application clearer, the implementation of the application will be further described in detail below in conjunction with the accompanying drawings.

[0026] Before using the polarization imaging system for imaging in the method provided by the present application and using a computer for data processing, it is first necessary to obtain a sample to be detected that may contain biomacromolecules to be detected.

[0027] One method provided in the embodiment of the present application is to drop the liquid to be detected on the nano-array substrate, and dry the nano-array substrate.

[0028] Such as figure 1 As shown, it is a schematic diagram of preparing a sample to be tested provided in the embodiment of the present application. In the figure, a device 103 for extracting biomacromolecules to be detected, a liquid 102 for biomacromolecules to be detected, and a nano-substrate 101 are included. Wher...

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Abstract

The invention discloses a biomacromolecule detection method and device based on a nano array. The method comprises the following steps: acquiring a scattering original image corresponding to a to-be-detected biomacromolecule combined with the nano array on a nano array substrate; drawing an initial polarization parameter map according to light intensity change information of each pixel point in the scattering original map; performing noise reduction processing on the initial polarization parameter atlas to obtain a polarization parameter atlas to be compared; comparing the polarization parameter atlas to be compared with polarization parameter atlas in a preset database to obtain a target polarization parameter atlas consistent with the polarization parameter atlas to be compared, and according to the target polarization parameter atlas and the comparison relationship between the number and position of the biomacromolecules and the polarization parameter atlas, quickly determining positions of the biomacromolecules on the nano array and the corresponding number of the biomacromolecules. According to the invention, low-concentration biomacromolecules can be rapidly detected.

Description

technical field [0001] The invention belongs to the technical field of biological detection, in particular to a method and device for detecting biological macromolecules based on a nano-array structure. Background technique [0002] Biomacromolecules include many types of molecular structures, including nucleic acids, proteins, and viruses. The identification of biological macromolecules is of great significance to the fields of medicine and biology such as DNA research, infectious animal and plant pathogens, and drug development. If the amount of biomacromolecules is weak, that is, biomacromolecules are in a low concentration state, it is difficult to be directly detected. [0003] In order to solve the problem that biomacromolecules are difficult to be detected at low concentrations, researchers have adopted various solutions. Common solutions include isolation and culture methods, immunological methods, probe-based labeling methods (fluorescence, PCR, colloidal gold), h...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N21/21
CPCG01N21/21
Inventor 熊吉川王宏泽刘学峰金霄张衡徐彬刘卫平倪斌
Owner NANJING UNIV OF SCI & TECH
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