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Terahertz photoacoustic detection device and method

A detection device and photoacoustic detection technology are applied in the field of terahertz, which can solve the problems of restricting the application of terahertz radiation and difficult to obtain the internal information of the sample, and achieve the effects of reducing cost, realizing detection sensitivity and low cost.

Pending Publication Date: 2022-03-25
TIANJIN UNIV
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Problems solved by technology

[0004] However, the existing terahertz biological detection uses terahertz reflectance spectroscopy and attenuated total reflectance spectroscopy, most of which require complex pretreatment of samples or direct detection of extremely thin (~200 μm) water-rich samples, which will make it difficult to obtain the inner surface of the sample. information, and the strong absorption signal of water tends to overwhelm the weak signal from target biomolecules, which greatly limits the further application of terahertz radiation in life sciences

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  • Terahertz photoacoustic detection device and method

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[0038] The present invention will be further described in detail below in conjunction with the accompanying drawings and embodiments. It should be understood that the specific embodiments described here are only used to explain the present invention, but not to limit the present invention. In addition, it should be noted that, for the convenience of description, only some structures related to the present invention are shown in the drawings but not all structures.

[0039] At present, the following characteristics of terahertz wave make it have great advantages in the field of biomedicine: 1. The photon energy of terahertz radiation is very low (1THz is about 4.1meV), compared with the current clinical X-rays (~keV), Terahertz radiation can be reduced by several orders of magnitude without causing ionization damage, so it may be more safely applied to in vivo detection; 2. The vibration and configuration changes of groups in many biomacromolecules, as well as the relationship ...

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Abstract

The embodiment of the invention discloses a terahertz photoacoustic detection device and method. The terahertz photoacoustic detection device comprises a light source module, an ultrasonic detection module, a processing module and a temperature control module, the light source module is used for emitting a wavelength-tunable terahertz light beam, and the terahertz light beam enters a to-be-detected sample and forms a photoacoustic signal after passing through the to-be-detected sample; the temperature control module is used for adjusting the temperature of the to-be-tested sample; the ultrasonic detection module is used for detecting a photoacoustic signal and converting the photoacoustic signal into an electric signal; the processing module is connected with the ultrasonic detection module and is used for acquiring an absorption spectrum in the to-be-detected sample according to the electric signal, so that fusion of a terahertz technology and a photoacoustic technology is realized, terahertz characteristic absorption information of a target detection object in the to-be-detected sample is acquired, and further application of terahertz radiation in life science is expanded; and the device has the characteristics of simple structure, convenience in operation and low cost.

Description

technical field [0001] Embodiments of the present invention relate to the field of terahertz technology, and in particular to a terahertz photoacoustic detection device and method. Background technique [0002] Terahertz (THz) waves refer to electromagnetic waves with a frequency in the range of 0.1 THz to 10 THz, located between the microwave and infrared regions. Due to the advantages of low photon energy, rich absorption spectrum, and good penetration, terahertz beams have shown great potential in many important fields such as physics, chemistry, electronic information, life science, material science, communication radar, and national security. application prospects. [0003] The photon energy of terahertz radiation is very low (~meV level) and will not cause ionization damage. The terahertz spectrum of matter contains rich physical and chemical information. Studying the spectrum of matter in this band is of great significance for the exploration of material properties. ...

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Application Information

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IPC IPC(8): G01N21/17G01N21/3581G01N21/01
CPCG01N21/1702G01N21/3581G01N21/01
Inventor 田震李娇江丽雯姚怡昕张克
Owner TIANJIN UNIV
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