5 results about "Photoacoustic Techniques" patented technology

The invention relates to the technical field of photoacoustic, in particular to a photoacoustic emission device, which comprises a light guide component, one end of the light guide component is connected with an emission end of a pulse or modulated laser light source so as to guide pulse or modulated laser to the other end of the light guide component; the photoacoustic conversion and ultrasonic emitting component is arranged at the preset position of the other end of the light guide component, a preset shape cavity is formed in the direction perpendicular to the central axis of the light guide component, and the cavity is filled with a light absorption medium and a thermal expansion material so as to absorb the pulse transmitted by the light guide component or modulate the laser to generate ultrasonic waves. Therefore, the problems that an existing opto-acoustic transducer cannot accurately act on a specific area, the spatial resolution is limited, the energy conversion efficiency is low, and the ultrasonic action direction is limited are solved, and the opto-acoustic transducer can be successfully applied to the fields of orientation and high-spatial-resolution regulation in ultrasonic cranial nerve regulation, needle point tracking in a puncture needle tracking scene and the like.

The application claims a kind of neonatal brain imaging system and method based on photoacoustic technology, belong to the field of medical devices. Including control module, excitation source module, neonatal brain photoacoustic data acquisition module, data output module and quantitative calculation module. The control module includes two computers and laser control instrument;The excitation source module includes high-frequency laser and its water cooling system;Neonatal brain photoacoustic data acquisition module contains focusing lens and optical fiber, wearable flexible ultrasonic transducer, multichannel acquisition card;The data output module contains computer matched with real-time imaging MarsonicsDAQ software and the imaging algorithm embedded in the software;Quantitative calculation module contains multispectral linear demixing algorithm and imaging software. The application provides high-resolution, high-contrast real-time imaging of neonatal brain tissue structure and cerebral hemodynamic parameters, which can be used as a complementary method to existing brain imaging techniques for auxiliary diagnosis.

The invention discloses a dual-targeting viscosity detection near-infrared fluorescence / photoacoustic probe as well as preparation and application thereof, and a probe ER-V2 with viscosity specific recognition capability is successfully designed and synthesized by taking trimethylbenzoindole as a core. The probe ER-V2 is based on a hemicyanine donor-pi-receptor (D-pi-A) structure, a p-toluene sulfonamide part is used for targeting endoplasmic reticulum, and an N, N-dimethylaminophenyl part is used for A beta plaque binding, so that precise double targeting is realized. The extended pi conjugation provides near-infrared emission, enhances viscosity sensitivity by limiting intramolecular rotation, and produces a strong photoacoustic signal. In combination with high sensitivity of near-infrared fluorescence and strong penetrating power of a photoacoustic technology in tissues, the probe ER-V2 can penetrate a blood brain barrier, realizes real-time and high-sensitivity near-infrared fluorescence / photoacoustic imaging in neuroglial cells and the brain of a mouse with the Alzheimer's disease, and has important significance on early diagnosis of the Alzheimer's disease. The fluorescent probe is expected to become a useful fluorescent tool for researching Alzheimer's disease and endoplasmic reticulum related diseases in the future.

This invention relates to the field of optical spectroscopy, specifically providing a hemispherical photoacoustic cell and a gas detection method. The hemispherical photoacoustic cell includes a cell body, a base, and a lamp plate. The cell body is provided with a resonant cavity, a resonant chamber, and an air vent. The resonant cavity is a hemispherical groove, and the resonant chamber has a through-hole structure. The resonant chamber is connected to the resonant chamber through a connecting hole. The resonant cavity and the resonant chamber have the same resonant frequency. The air vent penetrates the cell body and is connected to the resonant chamber. The base is fixedly connected to the cell body and is located at the opening of the resonant chamber to block it. The lamp plate is fixedly connected to the base and is located at the opening of the cell body. The lamp plate is provided with a light-emitting component to generate light with a preset wavelength, frequency, and intensity. A microphone is used to pick up the photoacoustic signal within the resonant chamber. This invention can effectively reduce the cost of photoacoustic gas measurement.

Reversibly switchable photoacoustic tomography (RS-PAT), a photoacoustic technique with enhanced sensitivity and resolution, is disclosed. RS-PAT utilizes a subtractive process for the formation of a photoacoustic image of a region containing a plurality of switchable photoacoustic probes. In various aspects, the photoacoustic detection in RS-PAT imaging occurs minimally twice: a first image obtained when the photoacoustic probe is in active (absorbing or ON) state and a second image obtained when the photoacoustic probe is in an inactive (less-absorbing or OFF) state. Subtraction of the second image from the first image is used to obtain the RS-PAT image.