A multimodal imaging detection system for skin diseases

Abstract

The invention provides a multimode imaging detection system for skin disease, characterized in that a supercontinuum laser is adopted, different wavelengths for specific skin tissues are selected to acquire hyperspectral and high-resolution confocal imaging, simultaneously the characteristic of deep depth of photoacoustic technique imaging is combined, and system integration of a hyperspectral imaging technique, a reflection type confocal imaging technique and a photoacoustic imaging technique is carried out to form the multimode optical imaging system. The multimode imaging detection system repairs the shortcoming of single-mode imaging in skin diagnosis, and compared with the single-modal technique, the multimode technique provides more complete information, improves the sensibility, accuracy and specificity in skin disease diagnosis, realizes hyperspectral, high-resolution and high-speed multimode optical molecular images for deep level skin disease diagnosis, provides a new technical means for diagnosis and clinical research on skin disease, is favorable for improving the diagnosis level of skin disease, and simultaneously can guide operation on skin disease and provide objective evaluation on medication of skin disease.

Description

technical field [0001] The invention relates to the technical field of optical imaging, in particular to a multimodal imaging detection system for skin diseases. Background technique [0002] Skin computed tomography imaging, also known as skin confocal, skin CT is an important tool for skin disease detection. At present, the principle of confocal is mainly used, and the laser point light source is used to replace the wide-field light source to illuminate the sample. At the same time, a pinhole is used to form a point detection in front of the detector. The illumination point and the detection point are conjugate with respect to the focal plane of the objective lens. Points outside the focal plane are not imaged at the detection point, which effectively suppresses the effects of stray light. Through the scanning mechanism such as the galvanometer or the translation stage, the three-dimensional scanning imaging in space is formed, and the three-dimensional image of the sampl...

AI Technical Summary

Problems solved by technology

[0003] However, the confocal imaging method has disadvantages: 1) The laser wavelengths used are relatively small. Due to the diversity of skin components, there are large differences in the absorption and reflection characteristics of various components for different wavelengths of light waves, which will lead to the use of The imaging effect is different at different wavelengths, and the best imaging effect cannot be achieved for specific skin components if the wavelength is small; 2) The imaging depth is insufficient

In addition, due to the complexity of skin tissue structure and the diversity of components, single modality imaging can provide relatively little information, which cannot meet actual needs

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