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Application of immune-related lncRNA expression profile in prediction of benefit and prognosis of small cell lung cancer adjuvant chemotherapy

A small cell lung cancer and prognosis technology, applied in the field of biomedicine, can solve problems such as easy metastasis, limited treatment methods, and drug resistance

Pending Publication Date: 2022-04-05
CANCER INST & HOSPITAL CHINESE ACADEMY OF MEDICAL SCI
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Problems solved by technology

However, most SCLC patients rapidly develop resistance after treatment even though they are sensitive to chemotherapy
Moreover, the patient's condition progresses rapidly and is prone to metastasis, so the treatment options are very limited.

Method used

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  • Application of immune-related lncRNA expression profile in prediction of benefit and prognosis of small cell lung cancer adjuvant chemotherapy
  • Application of immune-related lncRNA expression profile in prediction of benefit and prognosis of small cell lung cancer adjuvant chemotherapy
  • Application of immune-related lncRNA expression profile in prediction of benefit and prognosis of small cell lung cancer adjuvant chemotherapy

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Embodiment 1

[0033] Example 1. Prediction of curative effect of adjuvant chemotherapy for small cell lung cancer and application of drug resistance targets

[0034] Download the GSE65002 cohort from the GEO database (https: / / www.ncbi.nlm.nih.gov / geo / ) as a training cohort for building a small cell lung cancer prediction model; and collect small cell lung cancer patients from the National Cancer Center (NCC) Formalin-fixed paraffin-embedded FFPE tissues served as the validation cohort for model validation. The clinical characteristics of all patients are shown in Table 1.

[0035] Table 1 Clinical characteristics of patients with small cell lung cancer

[0036]

[0037] Note: SCLC, small cell lung cancer; OS, 5-year overall survival rate.

[0038] In the verification cohort, the inclusion criteria for small cell lung cancer patients are as follows: 1) The patient was diagnosed as small cell lung cancer by the National Cancer Center; 2) The patient’s diagnosis and treatment information ...

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Abstract

The invention discloses application of an immune-related lncRNA expression profile to prediction of benefit and prognosis of adjuvant chemotherapy of small cell lung cancer. One technical scheme to be protected in the invention is application of eight lncRNAs as markers in preparation of prognosis products and / or chemotherapy benefit products for predicting small cell lung cancer patients. And the eight types of lncRNAs comprise ENOX1-AS1, AC005162, LINC00092, RPL34-AS1, AC104135, AC015971, AC126544 and AP001189, and the eight types of lncRNAs comprise the following components: ENOX1-AS1, AC005162, LINC00092, RPL34-AS1, AC104135 Experiments prove that the risk value prediction model based on the eight lncRNA gene expression profiles can effectively predict prognosis and adjuvant chemotherapy benefit of the small cell lung cancer. The invention can provide a reference basis for clinical application of chemotherapy in SCLC patients in the future, and is helpful for improving the treatment effect of clinical small cell lung cancer.

Description

technical field [0001] The invention relates to the field of biomedicine, in particular to the application of immune-related lncRNA expression profiles to predict the benefit and prognosis of adjuvant chemotherapy for small cell lung cancer. Background technique [0002] With the remarkable progress of transcriptome sequencing technology, the key role of long-coding RNAs (Long-coding RNAs, lncRNAs) in tumorigenesis and progression has been elucidated. LncRNAs are a subset of RNAs longer than 200 nucleotides. LncRNAs affect tumor cells by regulating changes in the genome and transcriptome and affecting the tumor immune microenvironment. Importantly, lncRNAs actively regulate the expression of genes related to immune response and activation, which increases the heterogeneity of the tumor immune microenvironment by promoting the infiltration of different immune cells. [0003] Small cell lung cancer (SCLC) is a highly lethal high-grade neuroendocrine tumor characterized by sh...

Claims

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Application Information

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IPC IPC(8): C12Q1/6886G16B20/30
Inventor 赫捷孙楠张志慧张超奇骆玥君
Owner CANCER INST & HOSPITAL CHINESE ACADEMY OF MEDICAL SCI
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