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Application of m6A related lncRNA in predicting prognosis and chemotherapy response of small cell lung cancer

A small cell lung cancer and prognosis technology, applied in the field of biomedicine, can solve the problems of drug resistance, limited treatment methods, and easy metastasis

Pending Publication Date: 2022-01-21
CANCER INST & HOSPITAL CHINESE ACADEMY OF MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, most patients with small cell lung cancer rapidly develop resistance after treatment even though they are sensitive to chemotherapy
Moreover, the patient's condition progresses rapidly and is prone to metastasis, so the treatment options are very limited.

Method used

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  • Application of m6A related lncRNA in predicting prognosis and chemotherapy response of small cell lung cancer
  • Application of m6A related lncRNA in predicting prognosis and chemotherapy response of small cell lung cancer
  • Application of m6A related lncRNA in predicting prognosis and chemotherapy response of small cell lung cancer

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Example 1. Establishment and application of m6A-related lncRNA prediction model for patients with small cell lung cancer

[0034] Download the GSE65002 cohort from the GEO database (https: / / www.ncbi.nlm.nih.gov / geo / ) as a training cohort for building a small cell lung cancer prediction model; and collect small cell lung cancer at the National Cancer Center (NCC) Formalin-fixed paraffin-embedded FFPE tissues from patients served as a validation cohort for model validation. The clinical characteristics of all patients are shown in Table 1.

[0035] Table 1 Clinical characteristics of patients with small cell lung cancer

[0036]

[0037] Note: SCLC: small cell lung cancer; OS: overall survival.

[0038] In the verification cohort, the inclusion criteria for small cell lung cancer patients are as follows: 1) The patient was diagnosed as small cell lung cancer by the National Cancer Center; 2) The patient’s diagnosis and treatment information was complete; 3) The patie...

Embodiment 2

[0145] Example 2, Screening process of m6A-related lncRNA

[0146] 1. Screening of lncRNA related to 1m6A

[0147] (1) Expression of m6A regulatory elements in tumor tissue and normal tissue

[0148] The present invention is based on published literature ((1). Li Y, Xiao J, Bai J, Tian Y, Qu Y, Chen X, Wang Q, Li X, Zhang Y, and Xu J, Molecular characterization and clinical relevance of m (6)A regulators across 33 cancer types.Mol Cancer,2019.18(1):137.(2).Liu J,Harada BT,and He C,Regulation of Gene Expression by N(6)-methyladenosine in Cancer.Trends Cell Biol, 2019.29(6):487-499.(3).Huang H, Weng H, and Chen J, m(6) A Modification in Coding and Non-coding RNAs: Roles and Therapeutic Implications in Cancer. Cancer Cell, 2020.37(3) :270-288.(4).Nombela P,Miguel-López B,and Blanco S,The role of m(6)A,m(5)CandΨRNA modifications in cancer:Novel therapeutic opportunities.Mol Cancer,2021.20(1) :18.), summarized 30 m6A regulatory elements, including 11 Writer regulatory elements (...

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Abstract

The invention discloses application of m6A related lncRNA in predicting prognosis and chemotherapy response of small cell lung cancer. The technical scheme protected by the invention is application of substances for detecting expression quantities of seven lncRNA genes including WARS2-IT1, AC005162, AC130352, AC015971, FOXP1-IT1, AC040963 and LINC00355 in preparing a system for predicting prognosis and / or chemotherapy benefit of a patient with small cell lung cancer. The risk value of the patient to be detected is obtained by processing the expression quantity data of the seven lncRNA genes, the threshold value of the risk value is calculated and determined, and the prognosis and chemotherapy benefit condition of the patient with small cell lung cancer can be judged according to the threshold value. The application disclosed by the invention can provide reference basis for clinical application of future chemotherapy in SCLC patients, and is beneficial to improving the treatment effect of clinical small cell lung cancer.

Description

technical field [0001] The invention relates to the field of biomedicine, in particular to the application of m6A-related lncRNA in predicting the prognosis and chemotherapy response of small cell lung cancer. Background technique [0002] Small cell lung cancer (SCLC) is a highly lethal high-grade neuroendocrine tumor characterized by short tumor doubling time, rapid growth, and early metastatic spread. SCLC accounts for about 15% of lung cancers, and the five-year survival rate of patients is less than 7%. Despite the continuous development of new therapeutic measures such as molecular targeted drugs and immune checkpoint inhibitors, there has been no significant breakthrough in the treatment strategies for patients with small cell lung cancer in recent decades, and chemotherapy is still an irreplaceable first-line treatment for patients with small cell lung cancer . However, most SCLC patients rapidly develop drug resistance after treatment even though they are sensitiv...

Claims

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Application Information

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IPC IPC(8): C12Q1/6886
CPCC12Q1/6886G16B40/00G16H50/30G16H50/70C12Q2600/118C12Q2600/158C12Q2600/178
Inventor 赫捷孙楠张志慧张超奇吴芃张国超
Owner CANCER INST & HOSPITAL CHINESE ACADEMY OF MEDICAL SCI
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