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Adjuvant chemotherapy is given after the cancer is surgically removed. The surgery may not eliminate all the cancer cells, so the adjuvant chemotherapy treatment is used to kill any that may have been missed, such as cells that may have metastasized or spread to the liver.
Application of Peiyuan Gubenfang in reducing the toxicity of adjuvant chemotherapy after radical resection of non-small cell lung cancer
PendingCN122075648AImprove postoperative frailtyImprove weak constitutionAntinoxious agentsRespiratory disorderAdenophora strictaWolfiporia extensa
This invention belongs to the field of traditional Chinese medicine technology, specifically relating to the application of a formula for nourishing vital energy and strengthening the body in reducing the toxicity of adjuvant chemotherapy after radical resection of non-small cell lung cancer. This invention discloses a formula for nourishing vital energy and strengthening the body, characterized in that it is composed of the following components by weight: 15-30 parts raw Astragalus membranaceus, 9-21 parts prepared Rehmannia glutinosa, 15-30 parts stir-fried Dioscorea opposita, 9-15 parts Atractylodes macrocephala, 9-15 parts Poria cocos, 15-30 parts raw Coix lacryma-jobi, 9-15 parts Ophiopogon japonicus, 9-15 parts Asparagus cochinchinensis, 15-30 parts Adenophora stricta, 9-15 parts Ligustrum lucidum, 9-15 parts Eclipta prostrata, 9-15 parts stir-fried germinated barley, 9-15 parts stir-fried malt, and 3-6 parts prepared Glycyrrhiza uralensis. This invention can restore vital energy, reverse postoperative weakness, build a foundation for chemotherapy tolerance to reduce toxic side effects, improve chemotherapy tolerance, reduce the risk of interruption to ensure efficacy, improve quality of life during chemotherapy, and help prolong postoperative survival.
Owner:SHANGHAI PULMONARY HOSPITAL (SHANGHAI OCCUPATIONAL DISEASE PREVENTION & CONTROL INSTITUTE)
A traditional Chinese medicine compound for adjuvant chemotherapy of colorectal cancer and a preparation method thereof
This invention discloses a traditional Chinese medicine compound for adjuvant chemotherapy in colorectal cancer and its preparation method. The compound is made from the following raw materials in parts by weight: 15-30 parts of Polygonum cuspidatum and 10-20 parts of Citrus aurantium. The preparation method includes: purification treatment, physical primary cell wall disruption, sonic-enzyme synergistic deep cell wall disruption, enzyme inactivation and stabilization, extraction process, concentration process, alcohol precipitation purification, macroporous resin-directed debittering, multi-component complex molecular inclusion, bitter taste receptor antagonism and synergistic taste correction, drying and shaping. This invention's compound, through the precise combination of Polygonum cuspidatum and Citrus aurantium, achieves multi-target synergistic effects, which can reduce the toxic side effects of chemotherapy, enhance the killing effect of chemotherapy on tumors, directly inhibit the proliferation, migration, and invasion of colorectal cancer cells, improve the tumor microenvironment, and reverse chemotherapy resistance. This invention has the advantages of significant chemotherapy synergistic effect, clear toxicity reduction effect, high safety, and wide clinical applicability, and is suitable for adjuvant chemotherapy treatment of colorectal cancer.
Owner:THE FIRST AFFILIATED HOSPITAL OF ZHEJIANG CHINESE MEDICAL UNIVERSITY