Preparation method of embolism material

A technology of embolism and dispersed phase, which is applied in the field of medical materials, can solve the problems of poor embolization performance, and achieve the effects of broad-spectrum drug loading, convenient operation, and low viscosity

Active Publication Date: 2022-04-22
广东省广纳科技发展有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to overcome the defects and deficiencies of the poor embolic performance of existing emulsified lipiodol embolism materials, provide a kind of preparation method of embolism materials, add thermosensitive nano hydrogel in lipiodol emulsion by specific emulsification process, Form a stable O / W / O type composite emulsion, and use the state transition of the temperature-sensitive nano-hydrogel to further enhance the embolic performance of the embolic material

Method used

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  • Preparation method of embolism material

Examples

Experimental program
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Effect test

Embodiment 1

[0042] A method for preparing an embolism material, comprising the steps of:

[0043] S1. According to the formula in Table 1, take the temperature-sensitive nanogel and iodixanol and disperse them in water as the internal continuous phase;

[0044] S2. according to the formula of table 1, take paclitaxel and lipiodol, paclitaxel is dissolved in lipiodol, obtain the lipiodol medicinal liquid used as the internal dispersed phase, the internal dispersed phase and the internal continuous phase are mixed, under ice-bath conditions, Shear and emulsify at a speed of 8000 rpm for 30s, pause for 30s, cut for another 30s, pause for 30s, repeat the shearing and pauses so that the total shearing time is 9min, and obtain an O / W emulsion as the external dispersed phase;

[0045]S3. according to the formula of table 1, take paclitaxel and lipiodol by weighing, paclitaxel is dissolved in lipiodol, obtain the lipiodol liquid medicine that is used as the external continuous phase, mix the exte...

Embodiment 2

[0053] A method for preparing an embolism material, comprising the steps of:

[0054] S1. According to the formula in Table 2, take thermosensitive nanogel, iohexol and mitomycin and disperse them in water as the internal continuous phase;

[0055] S2. According to the formula in Table 2, take iodized oil as the internal dispersed phase, mix the internal dispersed phase and the internal continuous phase, under ice bath conditions, shear and emulsify at a speed of 7000 rpm for 60 seconds, pause for 30 seconds, and then shear 60s, pause for 30s, repeat the shearing and pause in this way, so that the total shearing time is 6min, and the O / W emulsion is obtained as the external dispersed phase;

[0056] S3. according to the formula in table 2, take paclitaxel and lipiodol, dissolve paclitaxel in lipiodol, obtain lipiodol medicinal liquid as the external continuous phase, mix the external dispersed phase with the external continuous phase, add surfactant, Under ice bath conditions...

Embodiment 3

[0061] A method for preparing an embolism material, comprising the steps of:

[0062] S1. According to the formula in Table 3, take the temperature-sensitive nanogel and iohexol and disperse them in water as the internal continuous phase;

[0063] S2. according to the formula of table 3, take paclitaxel and lipiodol, paclitaxel is dissolved in lipiodol, obtain the lipiodol liquid medicine that is used as the inner dispersed phase, the inner dispersed phase and the inner continuous phase are mixed, under ice bath condition, Shear and emulsify at a speed of 9000 rpm for 30s, pause for 60s, cut again for 30s, pause for 60s, repeat the shearing and pauses so that the total shearing time is 4min, and obtain an O / W emulsion as the external dispersed phase;

[0064] S3. according to the formula of table 3, take paclitaxel and lipiodol by weighing, paclitaxel is dissolved in lipiodol, obtain the lipiodol liquid medicine that is used as the external continuous phase, mix the external d...

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Abstract

The invention discloses a preparation method of an embolism material, and belongs to the technical field of medical materials. The preparation method of the embolism material comprises the following steps: S1, dispersing temperature-sensitive nanogel and / or a water-based developer in water to serve as an inner continuous phase; s2, iodine oil is used as an inner dispersion phase, the inner dispersion phase and the inner continuous phase are mixed, and under the ice bath condition, O / W emulsion is prepared and used as an outer dispersion phase; s3, iodine oil is used as an outer continuous phase, the outer dispersed phase and the outer continuous phase are mixed according to the volume ratio, and an O / W / O type composite emulsion, namely the embolism material, is prepared under the ice bath condition. According to the preparation method of the embolism material, the outer dispersion phase and the O / W / O type composite emulsion are both obtained through emulsification under the ice bath condition, the stability of the composite emulsion is guaranteed, the temperature-sensitive nanogel is stably dispersed in the O / W / O type composite emulsion, the defect that iodine oil is poor in embolism is overcome, and the embolism material has good embolism performance and fluidity.

Description

technical field [0001] The invention relates to the technical field of medical materials, and more specifically, to a preparation method of an embolism material. Background technique [0002] Embolic agents are important materials in interventional embolization operations. At present, the common preparation method of liquid embolic materials is the emulsion method. Lipiodol emulsion is currently the most commonly used embolic material, but its embolic performance is poor, and it needs to be further improved. Second embolization operation. [0003] In order to improve the embolic performance of lipiodol emulsion, there are also lipiodol emulsified embolic agents that will be combined with temperature-sensitive nano hydrogels in the prior art, including the following components in mass percentages: emulsified lipiodol 20-80%, Temperature-sensitive nano hydrogel 15-75%, gel factor 0.04-3.0%, taking the quality of emulsified iodized oil as a benchmark, said emulsified iodized o...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L24/06A61L24/02A61L24/00
CPCA61L24/001A61L24/0031A61L24/06A61L24/02A61L24/0015C08L33/24
Inventor 李涵孙海霞唐骆刘宏杨祥良
Owner 广东省广纳科技发展有限公司
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