The invention provides preparation and application of chitosan and propylene glycol alginate blended microcapsules, and relates to the field of microcapsule preparation and application. Chitosan is dissolved by an acetum solution with the mass percent concentration of 0.5-5%, propylene glycol alginate is dissolved by water, then the two solutions are blended, under a high-voltage static field, theblended solution is extruded into a 2-8% NaOH aqueous solution to form wet blended microcapsules, and after washing and drying, the dried blended microcapsules are obtained. The prepared chitosan andpropylene glycol alginate blended microcapsules can be taken as embolism substances for vascular embolism, the embolism substances are injected or conveyed into the target blood vessel through a catheter, so that the blood vessel at the target position is blocked, good expansibility can avoid that the microcapsules move in the blood vessel, the structures of the microcapsules are stable, and embolism can be more stable; the microcapsules can be applied to slow-release medicine and taken as a carrier of the slow-release medicine, the blended microcapsules are combined with the medicine to achieve the slow releasing effect of the medicine, and good slow releasing performance is achieved.