37results about How to "Embolization effect is good" patented technology

The invention relates to treatment instruments, in particular to an interventional treatment instrument made from a composite material and used for treating cerebral aneurysm embolism. Bead-like diamond spring coils of the treatment instrument can be coiled to form a space structure conforming to the arterial aneurysm through connecting points of diamonds and plays an arterial aneurysm stuffing role, meanwhile PU nanometer electrically-spun wires between the diamond spring coils can isolate blood flows, promote thrombosis in the arterial aneurysm and achieve arterial aneurysm closing purpose. The effective areas of the spring coils re increased through diamond support frameworks made of nickel-titanium memory alloy composite wires, and the embolism effect of the arterial aneurysm is improved. The PU nanometer electrically-spun wires among the diamond support frameworks are mixed with blood to form membranous substance, the arterial aneurysm can be closed, and thrombosis can be promoted. The using efficiency of the spring coils is improved, and the embolism effect is strengthened.

The invention belongs to the field of biopolymer and medical engineering, particularly relates to a method for preparing a polyvinyl alcohol / silicon dioxide composite micro-sphere with a core-shell structure by a one-step process, and provides a novel method for preparing the polyvinyl alcohol / silicon dioxide composite micro-sphere with the core-shell structure by forming a shell on a drop interface and coating a nuclear layer with silicon dioxide colloid particles by Pickering emulsion effects. According to the method, silicon dioxide particles can be automatically enriched on an oil-water drop interface, the core-shell structure is formed by the water-in-oil single emulsion template one-step process, colloidal silicon dioxide replaces traditional emulsifier, stability of emulsion is greatly improved, a microfluidic drop serves as a template, and size and shape controllability of the micro-drop template is ensured. The prepared composite micro-sphere is good in biocompatibility and can be applied to the field of biological medicines such as medicine carrying and anti-tumor embolism agents, and mechanical strength is improved.

A medial device such as a vascular occlusive device which includes a support structure and a bioactive expansible coating disposed on the support structure and an outer barrier coating which serves to prevent a reaction between the bioactive expansible foam coating and bodily fluids until the outer barrier is activated and removed by applying an external agent to the outer barrier thereby permitting expansion of the bioactive foam coating.

The invention discloses a preparation method of magnetic induction hyperthermia embolism microspheres. The preparation method comprises the following steps of by taking a dissolved matter obtained bydissolving biodegradable high molecular polymers with low transition temperature and super paramagnetic Fe3O4 nano-particles into dichloromethane as an oil phase, Span 80 as a surfactant and an aqueous solution dissolved with polyvinyl alcohol (PVA) as an internal water phase, dropwise adding a water phase in the oil phase under the conditions with low temperature and high shearing to form primaryemulsion; placing the primary emulsion in a membrane emulsification instrument for membrane emulsification under the low temperature condition; forming multiple emulsion in a continuous phase of an external water phase PVA after the primary emulsion permeates a membrane, and performing low-temperature solidification to obtain the magnetic induction hyperthermia embolism microspheres which meet the demand for clinic size. The obtained microspheres are arbitrarily adjustable in size in a range from 100 microns to 1000 microns, can realize rabbit orthotopic liver cancer model embolism hyperthermia under guidance of iconography and have potential application in the interventional hyperthermia field of orthotopic tumors.

The invention provides a bullet-shaped non-spherical micro-particle and microcapsule. A matrix of the micro-particle and micro-capsule is a polymerized photopolymerizable macromolecule, and the micro-particle and microcapsule is of an integrated bullet shape and consists of a similarly cone-shaped head portion and a cylindrical tail portion which are smoothly connected with each other; the microcapsule has at least one mutually independent chamber; and an oil phase solution is contained in the chamber. The invention further provides a method for continuously preparing the above bullet-shaped non-spherical micro-particle and microcapsule by using a microfluidic technique. The technical scheme provided by the invention can improve the flow characteristics and the movement rate of the microparticle and microcapsule in a channel, and improve the embedding effect of the microparticle and microcapsule. The microcapsule provided by the invention can realize entrapment and transport of activeingredients such as a drug.

The invention discloses a developing embolic material and a preparation method of the developing embolic material. Developable barium-alginate embolic microspheres encapsulating in-situ synthesis barium sulfate particles are prepared from one step by the adoption of an electrostatic spraying technology, integration of a developing agent and the embolic material is achieved, and the problems that when interventional therapy is clinically adopted, indirect developing exists and rechecking is difficult are solved. The mono-dispersion microspheres with the grain diameter being 100-1000 microns can be obtained by adjusting and controlling the electrostatic spraying parameter, so that the mono-dispersion microspheres with the grain diameter being 100-1000 microns are suitable for embolism of vessels of different calibers. The development agent, barium sulfate, and the barium-alginate microspheres are formed at the same time, and the barium sulfate particles are evenly distributed in the microspheres and firmly fixed. Extracorporeal simulation experiments prove that the developing microspheres are quite stable within the testing time of 50 days. A big-eared rabbit right kidney arterial embolism experiment proves that the developing microspheres have a good developing effect and an embolic effect. Because the electrostatic spraying technology has the characteristics of being simple, rapid and low in cost, the one-step preparation method has the production potential.

The invention relates to temperature controlled thermotherapy embolism sponge particles, which comprise macromolecular material and magnetic responding particles contained therein, the magnetic responding particles made of alloy material having a Curie temperature of 40-65 deg. C are dispersed in a cross-linked network formed by high polymers, the thermotherapy embolism sponge particles have grain diameter of 50-2000um, the water absorption rate is no less than 5 times of the amount of the particles, the magnetic responding particles account to 0.5-45 wt% of the total embolism sponge particles. The invention also discloses the process for preparing the embolism sponge particles.

The invention relates to a suspension of Fe#-[3]O#-[4] microparticle and iodized oil for treating liver and kidney tumor by embolizing and its preparation process, wherein the suspension wherein the suspension is prepared by fully mixing 50um-300um Fe3O4 particles with non-limited specification and iodized oil by the proportion of 85-110mg : 1ml.

The invention discloses an antineoplastic vascular embolic agent and its preparing process which consists of using asparagus root for extraction to obtain fine extract powder, charging iodine containing solution. The preparing method provided by the invention can effectively preserve the active constituents in the medicinal materials and simplify preparing traditional Chinese medicinal preparations.

The invention relates to a novel drug-loaded microsphere and a preparation method thereof. The preparation method comprises the following steps: pre-mixing a polyvinyl alcohol aqueous solution with hydroxyapatite particles, adding concentrated hydrochloric acid as a catalyst, adding a cross-linking agent glutaraldehyde to obtain a reaction solution, carrying out a pre-reaction for 3-30 seconds, dropwise adding a pre-reaction solution into a mixed oil phase containing liquid paraffin and sorbitan fatty acid ester before the pre-reaction solution is coagulated, stirring and reacting in an oil bath at 50-60 DEG C for at least 3 hours, and then filtering, washing and drying the reacted mixture to obtain the drug-loaded microspheres. The method provided by the invention is beneficial to batch production, the drug-loaded microspheres prepared by the method have high drug loading capacity and encapsulation efficiency and good slow release effect, and the hydroxyapatite particles are embeddedinto the polyvinyl alcohol after polymerization reaction, so that the drug-loaded microspheres have a certain developing function.

The invention provides a medical implant and a manufacturing method thereof. The medical implant comprises a spring ring, the spring ring comprises a first spring ring unit and a second spring ring unit, and the first spring ring unit is connected with the second spring ring unit; the outer surface of the first spring ring unit is located on a first curved surface, and the concave side of the first curved surface is arranged towards the second spring ring unit. The medical implant is used for blocking treatment of hemangioma, the first spring ring unit can adapt to the shape of the tumor wall of the hemangioma, the compactness of intra-tumor embolism is improved, and the treatment effect is improved.

The invention discloses a sugar water gel liquid emboliaztion agent for hemangioma cure. The sugar water gel liquid emboliaztion agent for hemangioma cure comprises that an effective embolism component is natural polysaccharide gellan gum, a developing component is metal tantalum powder and a solvent component is organic solvent dimethyl sulfoxide. The natural polysaccharide gellan gum is processed by oxidation of sugar chain cutting technology. The invention further discloses a preparation method of the sugar water gel liquid emboliaztion agent. According to the sugar water gel liquid emboliaztion agent for hemangioma cure and the preparation method of the sugar water gel liquid emboliaztion agent, an embolism condition is groped, the technical problems that the effective embolism and inducing thrombosis are formed in a tumor cavity range and a far-end drifting is prevented under the condition that auxiliary materials of sacculus, a support frame and the like are not needed are solved. The natural polysaccharide gellan gum in the embolism component plays a role in good biology compatibility and promoting the forming of the thrombosis. Requirements that the ideal liquid emboliaztion agent should be provided are met, thus a good embolism effect and high safety are achieved.

The invention discloses a preparation method and applications of mesoporous organic silicon oxide-coated ferroferric oxide embospheres. A purpose of the present invention is mainly to solve the problems of non-uniform size and difficult real-time monitoring of the existing embospheres. According to the preparation method, magnetic ferroferric oxide nanoparticles are used as a core, a surfactant isused as a template, inorganic and organic mixed silane is used as a silicon source precursor, and in an alcohol water solution, a mesoporous organic silicon oxide shell layer grows on the surface ofthe ferroferric oxide through a sol-gel process, such that the magnetic mesoporous silicon oxide microspheres obtained by the method have a particle size of 50-400 [mu]m, have characteristics of uniform size and good dispersibility, can be used for interventional embolization of tumors, have magnetic resonance imaging function, and can real-timely dynamically monitor embolization processes.

The invention discloses a novel drug-loadable microsphere and a preparation method thereof. The preparation method is to pre-mix polyvinyl alcohol aqueous solution and hydroxyapatite particles, then add concentrated hydrochloric acid as a catalyst, and then add a cross-linking agent pentadiene Aldehyde is obtained reaction liquid, after pre-reaction 3 seconds-30 seconds, pre-reaction liquid is added dropwise in the mixed oil phase that comprises liquid paraffin and sorbitan fatty acid ester before pre-reaction liquid condenses, at 50 ℃-60 Stirring and reacting in an oil bath at ℃ for at least 3 hours, and then filtering, washing and drying the reacted mixture to obtain drug-loading microspheres. The method of the present invention is beneficial to mass production, and the drug-loadable microspheres prepared by the method have higher drug-loading capacity and encapsulation efficiency, and the slow-release effect is good, and the hydroxyapatite particles are embedded after the polymerization reaction In polyvinyl alcohol, the drug-loaded microspheres have a certain developing function.

The invention provides a developing composite material and a preparation method thereof. The composite material is prepared from the following raw materials in percentage by weight: 20%-80% of non-developing high-molecular polymer, 80%-20% of impermeability improver and 0-10% of surface active agent. When the composite material is prepared, a melting stirrer or an extruder is adopted for materialmixing or even mixing in a solvent, the solvent is removed, and then the composite material is granulated or extruded into wires or used for preparing medical instruments. Furthermore, the invention provides application of the composite material, an implantable and interventional medical instrument adopting the composite material and a preparation method of the instrument. The composite material is filamentous and also has a good developing effect, and the developing composite material which has a developer content exceeding 50% and is suitable for an extrusion process can be prepared by utilizing the method. The medical instrument prepared from the composite material has a good developing effect and is beneficial to intraoperative operation and postoperative follow-up visit.

The invention provides preparation and application of chitosan and propylene glycol alginate blended microcapsules, and relates to the field of microcapsule preparation and application. Chitosan is dissolved by an acetum solution with the mass percent concentration of 0.5-5%, propylene glycol alginate is dissolved by water, then the two solutions are blended, under a high-voltage static field, theblended solution is extruded into a 2-8% NaOH aqueous solution to form wet blended microcapsules, and after washing and drying, the dried blended microcapsules are obtained. The prepared chitosan andpropylene glycol alginate blended microcapsules can be taken as embolism substances for vascular embolism, the embolism substances are injected or conveyed into the target blood vessel through a catheter, so that the blood vessel at the target position is blocked, good expansibility can avoid that the microcapsules move in the blood vessel, the structures of the microcapsules are stable, and embolism can be more stable; the microcapsules can be applied to slow-release medicine and taken as a carrier of the slow-release medicine, the blended microcapsules are combined with the medicine to achieve the slow releasing effect of the medicine, and good slow releasing performance is achieved.

The invention provides a polymeric microsphere with a disaccharide-based skeleton and a preparation method of the polymeric microsphere. The polymeric microsphere is prepared by the following steps of: irradiating allyl disaccharide ether and a photoinitiator; the chemical formula of the allyl disaccharide ether is shown as a formula (I) or a formula (II), wherein R1, R2, R3, R4, R5, R6, R7 and R8are hydrogen or alkenyl groups which are independent from one another, the alkenyl groups are allyl groups and / or methyl allyl groups, the number of the alkenyl groups is 2-8, and the functional group molar ratio of the photoinitiator to the allyl disaccharide ether is 6-46: 100. The invention also provides the preparation method of the polymeric microsphere with the disaccharide-based skeleton.The microsphere has the functional characteristics of excellent biocompatibility and dispersity, and the preparation method is green and environment-friendly, can be carried out at low temperature, ishigh in conversion rate, and provides feasibility for large-batch industrial production.

The embodiment of the invention discloses a detachable balloon catheter, and belongs to the field of medical instruments. The detachable balloon catheter comprises: a Y-shaped valve, wherein the Y-shaped valve comprises a Y-shaped valve main path and a Y-shaped valve bypass; a balloon catheter which is a coaxial double-cavity balloon catheter and comprises a balloon catheter outer cavity and a balloon catheter inner cavity, wherein the near end of the balloon catheter is connected with the Y-shaped valve; a detachable head end catheter, wherein a developing marking ring is arranged at the tail end of the detachable head end catheter; and a damping sleeve which is used for releasing and separating the balloon catheter from the detachable head end catheter. According to the detachable balloon catheter provided by the embodiment of the specification, the detachable head end catheter can be detached, so that an embolism agent can be better filled into a lesion part, the embolism effect of the lesion part is better, the surgical risk is reduced, and the surgical cure rate is increased.

The invention relates to an implant for treating pulmonary arteriovenous fistula. The implant is delivered into arteriovenous fistula by a delivery system to block a fistula orifice and formed by winding a primary helix which is formed by spirally winding an original wire, and the original wire is a platinum-tungsten alloy wire or a stainless steel ally wire or a medical magnetism alloy wire. Theimplant is reasonable in design, simple in structure, strong in radial supporting force, less prone to shedding and good in embolic effect.

The invention discloses a developing embolic material and a preparation method of the developing embolic material. Developable barium-alginate embolic microspheres encapsulating in-situ synthesis barium sulfate particles are prepared from one step by the adoption of an electrostatic spraying technology, integration of a developing agent and the embolic material is achieved, and the problems that when interventional therapy is clinically adopted, indirect developing exists and rechecking is difficult are solved. The mono-dispersion microspheres with the grain diameter being 100-1000 microns can be obtained by adjusting and controlling the electrostatic spraying parameter, so that the mono-dispersion microspheres with the grain diameter being 100-1000 microns are suitable for embolism of vessels of different calibers. The development agent, barium sulfate, and the barium-alginate microspheres are formed at the same time, and the barium sulfate particles are evenly distributed in the microspheres and firmly fixed. Extracorporeal simulation experiments prove that the developing microspheres are quite stable within the testing time of 50 days. A big-eared rabbit right kidney arterial embolism experiment proves that the developing microspheres have a good developing effect and an embolic effect. Because the electrostatic spraying technology has the characteristics of being simple, rapid and low in cost, the one-step preparation method has the production potential.

The invention relates to temperature controlled thermotherapy embolism sponge particles, which comprise macromolecular material and magnetic responding particles contained therein, the magnetic responding particles made of alloy material having a Curie temperature of 40-65 deg. C are dispersed in a cross-linked network formed by high polymers, the thermotherapy embolism sponge particles have grain diameter of 50-2000um, the water absorption rate is no less than 5 times of the amount of the particles, the magnetic responding particles account to 0.5-45 wt% of the total embolism sponge particles. The invention also discloses the process for preparing the embolism sponge particles.

The invention provides a monodisperse gelatin chitosan composite embolism microsphere with adjustable degradation performance and elasticity, the composite embolism microsphere comprises crosslinked chitosan and gelatin, the crosslinked chitosan is used as a skeleton, the gelatin is distributed in a three-dimensional network structure of the skeleton, the composite embolism microsphere is spherical, and the particle size variation coefficient does not exceed 5%. The degradation performance, the elasticity and the swelling performance of the composite embolism microsphere are adjusted by adjusting the mass ratio of the cross-linked chitosan to the gelatin in the composite embolism microsphere and the cross-linking density of the cross-linked chitosan. The invention also provides a preparation method of the composite embolism microsphere based on a microfluidic technology. According to the preparation method disclosed by the invention, the monodispersity of the composite embolism microspheres can be improved while continuous and non-toxic preparation of the composite embolism microspheres is realized, the possibility of false embolism is reduced, and controllable adjustment of degradation time and elasticity of the gelatin chitosan composite embolism microspheres is realized.

A composition comprising porous silica particles of the present invention has a modified surface which inhibits clotting and precipitation in blood, thereby effectively delivering physiologically active ingredients to target tissue or cells in the bloodstream. Also, in addition to the above advantage, a composition for an embolization procedure comprising porous silica particles of the present invention has the advantages of having biodegradability and sustained release properties such that excellent embolization effects may be obtained, and having excellent targeting properties for tumor tissue or cells and thereby causes few side effects.

The invention discloses a chemoembolism composition and application thereof, and belongs to the technical field of medical materials. The chemoembolization composition is an oil-in-water-in-oil type composite emulsion and comprises an outer continuous phase and an outer dispersion phase, the outer continuous phase is an oil phase, the outer dispersion phase is composed of an inner dispersion phase and an inner continuous phase, the inner dispersion phase is an oil phase, and the inner continuous phase is an aqueous solution of temperature-sensitive nanogel and a water-based developer. The chemoembolism composition has good embolism performance, secondary embolism chemotherapy is not needed, the balance requirement of fluidity and embolism performance required by the chemoembolism composition is met, and the X-ray developing capacity of the chemoembolism composition is remarkably improved through cooperation of the water-based developing agent and the iodophol; the X-ray developing capability is improved, and meanwhile, a good embolism effect is also achieved.

The invention discloses a preparation method of magnetic induction hyperthermia embolism microspheres. The preparation method comprises the following steps of by taking a dissolved matter obtained bydissolving biodegradable high molecular polymers with low transition temperature and super paramagnetic Fe3O4 nano-particles into dichloromethane as an oil phase, Span 80 as a surfactant and an aqueous solution dissolved with polyvinyl alcohol (PVA) as an internal water phase, dropwise adding a water phase in the oil phase under the conditions with low temperature and high shearing to form primaryemulsion; placing the primary emulsion in a membrane emulsification instrument for membrane emulsification under the low temperature condition; forming multiple emulsion in a continuous phase of an external water phase PVA after the primary emulsion permeates a membrane, and performing low-temperature solidification to obtain the magnetic induction hyperthermia embolism microspheres which meet the demand for clinic size. The obtained microspheres are arbitrarily adjustable in size in a range from 100 microns to 1000 microns, can realize rabbit orthotopic liver cancer model embolism hyperthermia under guidance of iconography and have potential application in the interventional hyperthermia field of orthotopic tumors.

The invention relates to a suspension of Fe#-[3]O#-[4] microparticle and iodized oil for treating liver and kidney tumor by embolizing and its preparation process, wherein the suspension wherein the suspension is prepared by fully mixing 50um-300um Fe3O4 particles with non-limited specification and iodized oil by the proportion of 85-110mg : 1ml.

The invention discloses a preparation method of an embolism material, and belongs to the technical field of medical materials. The preparation method of the embolism material comprises the following steps: S1, dispersing temperature-sensitive nanogel and / or a water-based developer in water to serve as an inner continuous phase; s2, iodine oil is used as an inner dispersion phase, the inner dispersion phase and the inner continuous phase are mixed, and under the ice bath condition, O / W emulsion is prepared and used as an outer dispersion phase; s3, iodine oil is used as an outer continuous phase, the outer dispersed phase and the outer continuous phase are mixed according to the volume ratio, and an O / W / O type composite emulsion, namely the embolism material, is prepared under the ice bath condition. According to the preparation method of the embolism material, the outer dispersion phase and the O / W / O type composite emulsion are both obtained through emulsification under the ice bath condition, the stability of the composite emulsion is guaranteed, the temperature-sensitive nanogel is stably dispersed in the O / W / O type composite emulsion, the defect that iodine oil is poor in embolism is overcome, and the embolism material has good embolism performance and fluidity.