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Chemoembolism composition and application thereof

A chemoembolization and composition technology, which is applied in the field of chemoembolization compositions, can solve the problems of unbalanced fluidity and embolism, poor embolism, etc., and achieve the effects of broad-spectrum drug loading, easy injection, and good embolization effect

Active Publication Date: 2022-05-13
广东省广纳科技发展有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to overcome the poor embolic properties of existing embolic agents, and the defects and deficiencies that fluidity and embolic properties cannot be balanced, and provide a chemoembolic composition, The temperature-sensitive nanogel, aqueous developer and lipiodol are designed into an O / W / O type composite emulsion, which achieves the balance of fluidity and embolism required by embolic agents, and has good embolism performance

Method used

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  • Chemoembolism composition and application thereof
  • Chemoembolism composition and application thereof
  • Chemoembolism composition and application thereof

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Embodiment 1

[0041] A chemoembolic composition, the chemoembolic composition is an oil-in-water-in-oil (O / W / O) type composite emulsion, comprising an external continuous phase and an external dispersed phase,

[0042] The outer continuous phase is an oil phase, the outer dispersed phase is composed of an inner dispersed phase and an inner continuous phase, the inner dispersed phase is an oil phase, and the inner continuous phase is an aqueous solution of a temperature-sensitive nanogel and an aqueous developer,

[0043] The temperature-sensitive nanogel is PNIP cross-linked with N,N'-methylenebisacrylamide, and the specific composition is shown in Table 1 below.

[0044] Table 1. Composition of chemoembolization compositions

[0045]

[0046]

Embodiment 2

[0048] A chemoembolic composition, the chemoembolic composition is an oil-in-water-in-oil (O / W / O) type composite emulsion, comprising an external continuous phase and an external dispersed phase,

[0049]The external continuous phase is an oil phase, the external dispersed phase is composed of an internal dispersed phase and an internal continuous phase, the internal dispersed phase is an oil phase, and the internal continuous phase is an aqueous solution of a temperature-sensitive nanogel and an aqueous developer,

[0050] The temperature-sensitive nanogel was selected as N,N'-methylenebisacrylamide cross-linked poly(NIP-co-AA), and the specific composition is shown in Table 2 below.

[0051] Table 2. Composition of chemoembolization compositions

[0052]

Embodiment 3

[0054] A chemoembolic composition, the chemoembolic composition is an oil-in-water-in-oil (O / W / O) type composite emulsion, comprising an external continuous phase and an external dispersed phase,

[0055] The external continuous phase is an oil phase, the external dispersed phase is composed of an internal dispersed phase and an internal continuous phase, the internal dispersed phase is an oil phase, and the internal continuous phase is an aqueous solution of a temperature-sensitive nanogel and an aqueous developer,

[0056] The temperature-sensitive nanogel was selected as N,N'-methylenebisacrylamide cross-linked poly(NIP-co-MAA), and the specific composition is shown in Table 3 below.

[0057] Table 3. Composition of chemoembolization compositions

[0058]

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Abstract

The invention discloses a chemoembolism composition and application thereof, and belongs to the technical field of medical materials. The chemoembolization composition is an oil-in-water-in-oil type composite emulsion and comprises an outer continuous phase and an outer dispersion phase, the outer continuous phase is an oil phase, the outer dispersion phase is composed of an inner dispersion phase and an inner continuous phase, the inner dispersion phase is an oil phase, and the inner continuous phase is an aqueous solution of temperature-sensitive nanogel and a water-based developer. The chemoembolism composition has good embolism performance, secondary embolism chemotherapy is not needed, the balance requirement of fluidity and embolism performance required by the chemoembolism composition is met, and the X-ray developing capacity of the chemoembolism composition is remarkably improved through cooperation of the water-based developing agent and the iodophol; the X-ray developing capability is improved, and meanwhile, a good embolism effect is also achieved.

Description

technical field [0001] The present invention relates to the technical field of medical materials, more specifically, to a chemoembolization composition and its application. Background technique [0002] Lipiodol emulsion is currently widely used in transcatheter arterial chemotherapy (Trans-Arterial Chemo-Embolization, TACE), it has good fluidity, can pass through the microcatheter smoothly, and achieve tumor peripheral blood vessel embolization, however, lipiodol The embolism of emulsion is poor, it is easy to be washed and metabolized by blood, and recanalization occurs. In this case, it is often necessary to use solid embolic agents such as gelatin sponge and PVA for secondary embolization therapy, and the operation of secondary embolization therapy is cumbersome. Increased costs and sometimes embolism complications. [0003] Aiming at the problem of poor embolism of embolic agent lipiodol emulsion, the prior art discloses a developable composite microsphere embolic agen...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L24/06A61L24/00
CPCA61L24/06A61L24/001A61L24/0015A61L2300/416C08L33/24
Inventor 李涵孙海霞唐骆刘宏杨祥良
Owner 广东省广纳科技发展有限公司
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