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Preparation method and applications of mesoporous organic silicon oxide-coated ferroferric oxide embospheres

A technology of triiron tetroxide and organic silicon oxide, which can be used in the preparation of microspheres, microcapsule preparations, and preparations for in vivo tests, etc. Great clinical translation value, uniform size, and environmentally friendly effects

Active Publication Date: 2019-08-30
滕兆刚
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] In view of the above-mentioned problems, in order to overcome the shortcomings in the clinical application of the existing embolic microspheres, such as uneven size and difficulty in monitoring embolic microspheres, the present invention provides a mesoporous organosilica-coated ferric oxide embolic microsphere, which will It is used for interventional embolization therapy, not only has a uniform size, but also can be used for magnetic resonance imaging, so as to achieve effective embolization of tumors and monitor the effect of embolization

Method used

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  • Preparation method and applications of mesoporous organic silicon oxide-coated ferroferric oxide embospheres
  • Preparation method and applications of mesoporous organic silicon oxide-coated ferroferric oxide embospheres
  • Preparation method and applications of mesoporous organic silicon oxide-coated ferroferric oxide embospheres

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Experimental program
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Effect test

Embodiment 1

[0030] (1) Preparation of magnetic Fe by hot solvent method 3 o 4 Nanoparticles. The specific method is: 0.65g FeCl 3 , 0.2g sodium citrate, and 1.2g sodium acetate were dissolved in 20mL ethylene glycol and stirred evenly by magnetic force, then transferred to a 30mL reactor and reacted at 200°C for 10h, after cooling to room temperature, washed three times with deionized water, vacuum Oven drying for 12 hours to obtain magnetic ferric oxide particles;

[0031] (2) 0.2g of the above-prepared Fe 3 o 4 Nanoparticles were dispersed in 800mL water-alcohol solution (alcohol-water ratio 3:1), ultrasonically dispersed, then 10mL 25wt% ammonia water and 100mL TEOS were added, stirred at room temperature for 6h, centrifuged and washed with ethanol three times;

[0032] (3) Disperse the product of the above (2) into 1000mL alcohol water solution, alcohol water 8:1, add 1g CTAB surfactant, stir at room temperature for 1h, add 5mL 25wt% ammonia water, 100mL TEOS+BTSE mixed silicon s...

Embodiment 2

[0037] (1) Preparation of magnetic Fe by hot solvent method 3 o 4 Nanoparticles: 0.65g FeCl 3 , 0.2g sodium citrate, and 1.2g sodium acetate were dissolved in 20mL ethylene glycol and stirred evenly by magnetic force, then transferred to a 30mL reactor and reacted at 200°C for 10h, after cooling to room temperature, washed three times with deionized water, 60°C Dry in a vacuum oven for 12 hours to obtain magnetic ferric oxide particles;

[0038](2) 0.2g of the above-prepared Fe 3 o 4 Nanoparticles were dispersed in 800mL hydroalcoholic solution, the volume ratio of ethanol and water was 3:1, ultrasonically dispersed, then 10mL 25wt% ammonia water and 100mL TEOS were added, stirred at room temperature for 6h, centrifuged, and washed with ethanol three times;

[0039] (3) Disperse the product of step 2 into 1000mL alcohol aqueous solution, the volume ratio of ethanol and water is 8:1, add 3gCTAB surfactant, stir at room temperature for 1h, add 15mL 25wt% ammonia water, 300mL...

Embodiment 3

[0043] (1) Preparation of magnetic Fe by hot solvent method 3 o 4 Nanoparticles: 0.65g FeCl 3 , 0.2g sodium citrate, and 1.2g sodium acetate were dissolved in 20mL ethylene glycol and stirred evenly by magnetic force, then transferred to a 30mL reactor and reacted at 200°C for 10h, after cooling to room temperature, washed three times with deionized water, 60°C Dry in a vacuum oven for 12 hours to obtain magnetic ferric oxide particles;

[0044] (2) 0.2g of the above-prepared Fe 3 o 4 Nanoparticles were dispersed in 800mL hydroalcoholic solution, the volume ratio of ethanol and water was 3:1, ultrasonically dispersed, then 10mL 25wt% ammonia water and 100mL TEOS were added, stirred at room temperature for 6h, centrifuged, and washed with ethanol three times;

[0045] (3) Disperse the product of step 2 into 1000mL alcohol aqueous solution, the volume ratio of ethanol and water is 4:1, add 3gCTAB surfactant, stir at room temperature for 1h, add 15mL 25wt% ammonia water, 300m...

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Abstract

The invention discloses a preparation method and applications of mesoporous organic silicon oxide-coated ferroferric oxide embospheres. A purpose of the present invention is mainly to solve the problems of non-uniform size and difficult real-time monitoring of the existing embospheres. According to the preparation method, magnetic ferroferric oxide nanoparticles are used as a core, a surfactant isused as a template, inorganic and organic mixed silane is used as a silicon source precursor, and in an alcohol water solution, a mesoporous organic silicon oxide shell layer grows on the surface ofthe ferroferric oxide through a sol-gel process, such that the magnetic mesoporous silicon oxide microspheres obtained by the method have a particle size of 50-400 [mu]m, have characteristics of uniform size and good dispersibility, can be used for interventional embolization of tumors, have magnetic resonance imaging function, and can real-timely dynamically monitor embolization processes.

Description

technical field [0001] The invention belongs to the field of advanced materials, and in particular relates to a mesoporous organic silicon oxide-wrapped ferric iron tetroxide plug microsphere, a preparation method and application thereof. Background technique [0002] Cancer is a highly lethal disease that poses a great threat to human life and health. Interventional embolization therapy is a commonly used method for clinical treatment of cancer, and the performance of embolizing agents will determine the effect of treatment. At present, lipiodol is commonly used clinically as an embolic agent. This liquid embolic agent is effective for the embolization of tiny tumor blood vessels, but it is difficult to tie down the arteries supplying blood to the tumor, which is likely to cause tumor recurrence. In addition, the liquid embolic agent is unstable and prone to Cause embolism ectopic, affect the function of normal body. [0003] Embolization microspheres are a new type of emb...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01J13/02A61K49/08A61K49/18A61L31/02A61L31/14
CPCB01J13/02A61K49/183A61K49/08A61L31/028A61L31/14A61L2300/416
Inventor 滕兆刚苏晓丹党萌
Owner 滕兆刚
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