Method for preparing polyvinyl alcohol/silicon dioxide composite micro-sphere with core-shell structure by one-step process

A silicon dioxide, core-shell structure technology, applied in the fields of biopolymers and medical engineering, can solve the problems of uneven size of composite microspheres, inability to precisely control, and high process requirements, avoiding toxic side effects, improving mechanical strength, and improving biological properties. good compatibility

Inactive Publication Date: 2017-12-22
NANJING WISDOM BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Usually, researchers use multiple emulsion templates such as water / oil / water or oil / water / oil composite droplets to prepare such microspheres. The properties of the continuous phase and the oil phase, etc., to improve the stability of the multiple emulsion template; and due to the use of emulsifiers, the application of its products in the fields of food, cosmetics, and medicine has been limited to a certain extent
[0004] Chinese patent: A preparation method of polyvinyl alcohol / silicon dioxide composite microspheres (application number: 201510750935) discloses a preparation method of polyvinyl alcohol / silicon dioxide composite microspheres. Ethyl ester is fully hydrolyzed in PVA solution to form uniform PVA / SiO 2 Composite sol; the sol is dispersed and cross-linked in a water-in-oil system that does not contain surfactants, and finally PVA / SiO is obtained 2 Composite microspheres; however, the size of the composite microspheres prepared by this method is not uniform, and cannot be precisely regulated

Method used

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  • Method for preparing polyvinyl alcohol/silicon dioxide composite micro-sphere with core-shell structure by one-step process
  • Method for preparing polyvinyl alcohol/silicon dioxide composite micro-sphere with core-shell structure by one-step process
  • Method for preparing polyvinyl alcohol/silicon dioxide composite micro-sphere with core-shell structure by one-step process

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Dissolve 1.0 g of polyvinyl alcohol PVA124 in 10 mL of deionized water as the water phase by heating deionized water to 95°C under a nitrogen atmosphere; disperse 0.2 g of trimethylchlorosilane-modified silica in 20 ml of mineral oil, as the oil phase. The water phase is a discontinuous phase, and the oil phase is a continuous phase. Through the microfluidic channel of the glass capillary microfluidic chip, the speed of the water phase is controlled to be 1000 microliters / hour, and the speed of the oil phase is 2000 microliters / hour to generate oil. Water-encapsulated droplets ( figure 1 ), after collecting the droplets for 1 hour, put the collected droplets into the refrigerator, control the temperature at about -20°C, and freeze. Take it out after 12 hours and thaw at room temperature. This freezing-thawing cycle was repeated 4 times, and the obtained microspheres were repeatedly washed with n-hexane or acetone and filtered to finally obtain polyvinyl alcohol / silica...

Embodiment 2

[0035] Example 2 Under a nitrogen atmosphere, by heating deionized water to 95°C, dissolve 1.5g of polyvinyl alcohol PVA124 in 10mL of deionized water as the water phase; disperse 1g of hexadecylchlorosilane-modified silica In 20ml soybean oil, as the oil phase. Make the water phase a discontinuous phase and the oil phase a continuous phase through the microfluidic channel of the glass microfluidic chip, control the speed of the water phase to 1000 microliters / hour, and the speed of the oil phase to 2000 microliters / hour to generate water-in-oil After collecting the droplets for 1 hour, put the collected droplets into the refrigerator, control the temperature at about -30°C, and freeze them. Take it out after 6 hours and thaw at room temperature. Repeat this freeze-thaw cycle 3 times, wash the obtained microspheres repeatedly with n-hexane or acetone and filter, and finally obtain polyvinyl alcohol / silica composite microspheres, which are soaked in water to swell, as shown in...

Embodiment 3

[0037]Example 3 Under a nitrogen atmosphere, by heating deionized water to 95°C, dissolve 2.5g of polyvinyl alcohol PVA124 in 10mL of deionized water as the water phase; disperse 1g of fluorosilane-modified silica in 20ml of fluorine oil (FC-40), as the oil phase. Make the water phase a discontinuous phase and the oil phase a continuous phase through the microfluidic channel of the polymethylsiloxane microfluidic chip, control the water phase speed to 1000 microliters / hour, and the oil phase speed to 2000 microliters / hour, Water-in-oil droplets are generated, and after collecting the droplets for 1 hour, the collected droplets are placed in a refrigerator, and the temperature is controlled at about -20°C for freezing. Take it out after 12 hours and thaw at room temperature. This freeze-thaw cycle was repeated 5 times, and the resulting microspheres were repeatedly washed with n-hexane or acetone and filtered to obtain polyvinyl alcohol / silica composite microspheres.

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Abstract

The invention belongs to the field of biopolymer and medical engineering, particularly relates to a method for preparing a polyvinyl alcohol / silicon dioxide composite micro-sphere with a core-shell structure by a one-step process, and provides a novel method for preparing the polyvinyl alcohol / silicon dioxide composite micro-sphere with the core-shell structure by forming a shell on a drop interface and coating a nuclear layer with silicon dioxide colloid particles by Pickering emulsion effects. According to the method, silicon dioxide particles can be automatically enriched on an oil-water drop interface, the core-shell structure is formed by the water-in-oil single emulsion template one-step process, colloidal silicon dioxide replaces traditional emulsifier, stability of emulsion is greatly improved, a microfluidic drop serves as a template, and size and shape controllability of the micro-drop template is ensured. The prepared composite micro-sphere is good in biocompatibility and can be applied to the field of biological medicines such as medicine carrying and anti-tumor embolism agents, and mechanical strength is improved.

Description

technical field [0001] The invention belongs to the fields of biopolymers and medical engineering, and particularly relates to a method for preparing polyvinyl alcohol / silicon dioxide composite microspheres with a core-shell structure in one step. Background technique [0002] In the treatment of diseases such as liver tumors and vascular malformations, embolization therapy is a relatively new and useful method. Generally, embolization therapy is guided by medical imaging equipment, and the embolic agent is introduced into the human body through special catheters, guide wires and other precision instruments to block the blood supply and nutrition of the target area and achieve the therapeutic purpose of shrinking the lesion. It can be seen that embolic materials and their properties play a key role in the application of this technology. Among them, microsphere embolic agents, as a new type of particle embolic agents, have a strong targeting effect and can be used as drug ca...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01J13/06
CPCB01J13/06
Inventor 张静沈宇周进陈捷
Owner NANJING WISDOM BIOTECH
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